Results 81 to 90 of about 549,591 (370)

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

A Mathematical Model of Tripartite Synapse: Astrocyte Induced Synaptic Plasticity

, 2012
In this paper we present a biologically detailed mathematical model of tripartite synapses, where astrocytes modulate short-term synaptic plasticity. The model consists of a pre-synaptic bouton, a post-synaptic dendritic spine-head, a synaptic cleft and ...
Majumdar, Kaushik, Tewari, Shivendra
core   +1 more source

Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses [PDF]

, 2006
Synaptic vesicle (SV) exocytosis mediating neurotransmitter release occurs spontaneously at low intraterminal calcium concentrations and is stimulated by a rise in intracellular calcium.
A. Scheuber, Blagoveshchenskaya, Dell'Angelica, Fa  ndez, G. Raposo, Goda, Guti  rrez, Hayashi, J.-C. Poncer, Kamiya, Kantheti, L. Danglot, Li, Lopantsev, Musleh, Muzerelle, R. Rudge, Rizzoli, Rosenmund, Sakaba, Schoch, Sj  str  m, Stobrawa, Stoppini, Sudhof, Sugita, Sugita, T. Binz, T. Galli, Takei, Vogt, Woodhall, Xu   +32 more
core   +6 more sources

A liquid phase of synapsin and lipid vesicles

Science, 2018
Going through a phase Neuronal communication at synapses relies on regulated neurotransmitter secretion. Neurotransmitters are stored in small vesicles that are organized in clusters within nerve terminals.
Dragomir Milovanovic, Yumei Wu, X. Bian, P. De Camilli   +3 more
semanticscholar   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission

Nature Neuroscience, 2012
Synaptic vesicles in the brain harbor several soluble N-ethylmaleimide-sensitive-factor attachment protein receptor (SNARE) proteins. With the exception of synaptobrevin2, or VAMP2 (syb2), which is directly involved in vesicle fusion, the role of these ...
J. Raingo, M. Khvotchev, Pei Liu, F. Darios, Ying C. Li, Denise M. O. Ramirez, M. Adachi, Philippe Lemieux, K. Tóth, B. Davletov, E. Kavalali   +10 more
semanticscholar   +1 more source

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source

Rabconnectin3α Promotes Stable Activity of the H+ Pump on Synaptic Vesicles in Hair Cells

Journal of Neuroscience, 2012
Acidification of synaptic vesicles relies on the vacuolar-type ATPase (V-ATPase) and provides the electrochemical driving force for neurotransmitter exchange.
Zev Einhorn, Josef G. Trapani, Qianyong Liu, T. Nicolson   +3 more
semanticscholar   +1 more source

Near‐Infrared Organic Photovoltaic Electrodes for Subretinal Neurostimulation

Advanced Functional Materials, EarlyView.
Organic photovoltaic electrodes based on the D18:Y6 blend enable precise and light‐controlled activation of retinal ganglion cells in a degenerating retina. NIR Light‐driven activation of retinal ganglion cells, tunable stimulation parameters, and biocompatibility with human retinal organoids highlight their potential for next‐generation prosthetics ...
Andrea Corna, Katarina Gugujonovic, Manuela Schiek, Alessandro Bellapianta, Paul Werginz, Amelie Ziller, Markus Clark Scharber, Ahmad Salti, Matthias Bolz, Mihai Irimia‐Vladu, Günther Zeck   +10 more
wiley   +1 more source

Use of fluorescent probes to follow membrane traffic in nerve terminals

Brazilian Journal of Medical and Biological Research, 1998
Optical tracers in conjunction with fluorescence microscopy have become widely used to follow the movement of synaptic vesicles in nerve terminals. The present review discusses the use of these optical methods to understand the regulation of exocytosis ...
Guatimosim C., Romano-Silva M.A., Gomez M.V., Prado M.A.M.   +3 more
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