Results 51 to 60 of about 65,212 (288)

Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells. [PDF]

, 2005
Lipid raft membrane compartmentalization and membrane-associated guanylate kinase (MAGUK) family molecular scaffolds function in establishing cell polarity and organizing signal transducers within epithelial cell junctions and neuronal synapses. Here, we
Miceli, M Carrie, Patel, Viresh, Round, June L, Schoenberger, Stephen P, Tomassian, Tamar, Zhang, Min   +5 more
core  

Associative learning elicits the formation of multiple-synapse boutons [PDF]

, 2001
The formation of new synapses has been suggested to underlie learning and memory. However, previous work from this laboratory has demonstrated that hippocampus-dependent associative learning does not induce a net gain in the total number of hippocampal ...
Berry, R. W., Disterhoft, J. F., Geinisman, Y., Power, J. M., Van der Zee, E. A.   +4 more
core   +2 more sources

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Exosomes regulate neurogenesis and circuit assembly. [PDF]

, 2019
Exosomes are thought to be released by all cells in the body and to be involved in intercellular communication. We tested whether neural exosomes can regulate the development of neural circuits.
Carromeu, Cassiano, Cline, Hollis T, McClatchy, Daniel R, Mesci, Pinar, Muotri, Alysson R, Schiapparelli, Lucio, Sharma, Pranav, Yates, John R   +7 more
core  

Neural development features: Spatio-temporal development of the Caenorhabditis elegans neuronal network

, 2010
The nematode Caenorhabditis elegans, with information on neural connectivity, three-dimensional position and cell linage provides a unique system for understanding the development of neural networks. Although C.
A Hidalgo, A Kuzin, BL Chen, C Benard, C Stam, CE Adler, CS Branda, DA Goodenough, DH Hall, DJ Watts, DV Vactor, E Bullmore, EB Chen, ESBC Ang, F Nisbach, FD Miller, J Zheng, JE Sulston, JE Sulston, JG White, JL Goldberg, Karl J. Friston, LdF Costa, LN Gillespie, M Buechner, M Kaiser, M Kaiser, M Kaiser, M Takeichi, Marcus Kaiser, O Hobert, O Sporns, P Hagmann, Sreedevi Varier, T Serafini, TB Achacoso, WG Wadsworth, Y Choe, YY Ahn, ZF Altun   +39 more
core   +4 more sources

A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. [PDF]

, 2012
EphB receptor tyrosine kinases control multiple steps in nervous system development. However, it remains unclear whether EphBs regulate these different developmental processes directly or indirectly.
Ataman, Bulent, Bloodgood, Brenda L, Cowan, Christopher W, Greenberg, Michael E, Ho, Hsin-Yi Henry, Malik, Athar N, Robichaux, Michael A, Rubin, Alex A, Sharma, Nikhil, Shokat, Kevan M, Soskis, Michael J, Zhang, Chao, Zieg, Janine   +12 more
core   +1 more source

Cocaine Triggers Astrocyte-Mediated Synaptogenesis

Biological Psychiatry, 2021
Synaptogenesis is essential in forming new neurocircuits during development, and this is mediated in part by astrocyte-released thrombospondins (TSPs) and activation of their neuronal receptor, α2δ-1. Here, we show that this developmental synaptogenic mechanism is utilized during cocaine experience to induce spinogenesis and the generation of AMPA ...
Junshi Wang, King-Lun Li, Avani Shukla, Ania Beroun, Masago Ishikawa, Xiaojie Huang, Yao Wang, Yao Q. Wang, Yue Yang, Noah D. Bastola, Hugh H. Huang, Lily E. Kramer, Terry Chao, Yanhua H. Huang, Susan R. Sesack, Eric J. Nestler, Oliver M. Schlüter, Yan Dong   +17 more
openaire   +4 more sources

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Orexin A in cortical cultures: expression and effect on synaptogenesis during development [PDF]

, 2011
Orexin-A (OXA) is an excitatory hypothalamic neurotransmitter and ligand for Orexin Receptor-1 (OR1), isolated from a small group of hypothalamic neurons.
Feber, Joost le, Rutten, Wim L.C., Stoyanova, Irina I.   +2 more
core   +5 more sources

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source