Results 31 to 40 of about 9,868 (165)

Expression of Proteins Linked to Exocytosis and Neurotransmission in Patients with Creutzfeldt–Jakob Disease

Neurobiology of Disease, 1999
In order to characterize synaptic involvement in human spongiform encephalopathies, the expression of synaptic vesicle-associated proteins, synaptophysin and synapsin-I, and presynaptic plasma membrane proteins, synaptosomal-associated protein of 25 kDa (
I. Ferrer, R. Rivera, R. Blanco, E. Mart
doaj   +1 more source

Evaluation of cerebrospinal fluid levels of synaptic vesicle protein, VAMP-2, across the sporadic Alzheimer’s disease continuum

Alzheimer’s Research & Therapy, 2023
Background Synapse loss is an early event that precedes neuronal death and symptom onset and is considered the best neuropathological correlate of cognitive decline in Alzheimer’s disease (AD).
Julie Goossens, Alba Cervantes González, Nele Dewit, Laia Lidón, Juan Fortea, Daniel Alcolea, Alberto Lleó, Olivia Belbin, Eugeen Vanmechelen   +8 more
doaj   +1 more source

Insights into early pathogenesis of sporadic Alzheimer’s disease: role of oxidative stress and loss of synaptic proteins

Frontiers in Neuroscience
Oxidative stress, induced by impaired insulin signaling in the brain contributes to cognitive loss in sporadic Alzheimer’s disease (sAD). This study evaluated early hippocampal oxidative stress, pre- and post-synaptic proteins in intraperitoneal (IP) and
Mubeen A. Ansari, Muddanna Sakkattu Rao, Aishah Al-Jarallah   +2 more
doaj   +1 more source

Myosin phosphatase and RhoA-activated kinase modulate neurotransmitter release by regulating SNAP-25 of SNARE complex. [PDF]

PLoS ONE, 2017
Reversible phosphorylation of neuronal proteins plays an important role in the regulation of neurotransmitter release. Myosin phosphatase holoenzyme (MP) consists of a protein phosphatase-1 (PP1) catalytic subunit (PP1c) and a regulatory subunit, termed ...
Dániel Horváth, István Tamás, Adrienn Sipos, Zsuzsanna Darula, Bálint Bécsi, Dénes Nagy, Judit Iván, Ferenc Erdődi, Beáta Lontay   +8 more
doaj   +1 more source

Clemastine Ameliorates Perioperative Neurocognitive Disorder in Aged Mice Caused by Anesthesia and Surgery

Frontiers in Pharmacology, 2021
Perioperative neurocognitive disorder (PND) leads to progressive deterioration of cognitive function, especially in aged patients. Demyelination is closely associated with cognitive dysfunction.
Wensi Wu, Xiaojun Zhang, Jiaxin Zhou, Hongmei Yang, Junjun Chen, Le Zhao, Junying Zhong, Wei-jye Lin, Wei-jye Lin, Zhi Wang   +9 more
doaj   +1 more source

Serum miRNAs Expression and SNAP-25 Genotype in Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2019
MicroRNAs (miRNAs) are small non-coding RNAs that control gene expression by binding their 3′ untranslated region (3′UTR) region; these molecules play a fundamental role in several pathologies, including Alzheimer’s disease (AD).
Simone Agostini, Roberta Mancuso, Gaia Liuzzo, Elisabetta Bolognesi, Andrea Saul Costa, Anna Bianchi, Mario Clerici, Mario Clerici   +7 more
doaj   +1 more source

Structural and Functional Interactions between Transient Receptor Potential Vanilloid Subfamily 1 and Botulinum Neurotoxin Serotype A. [PDF]

PLoS ONE, 2016
BACKGROUND:Botulinum neurotoxins are produced by Clostridium botulinum bacteria. There are eight serologically distinct botulinum neurotoxin isoforms (serotypes A-H).
Xiaqing Li, Julie A Coffield
doaj   +1 more source

Ameliorative effects of omega-lycotoxin-Gsp2671e purified from the spider venom of Lycosa praegrandis on memory deficits of glutamate-induced excitotoxicity rat model

Frontiers in Pharmacology, 2022
Memory impairment is one of the main complications of Alzheimer’s disease (AD). This condition can be induced by hyper-stimulation of N-Methyl-D-aspartate receptors (NMDARs) of glutamate in the hippocampus, which ends up to pyramidal neurons ...
Mohammad Keimasi, Kowsar Salehifard, Marzieh Shahidi, Fariba Esmaeili, Noushin Mirshah Jafar Esfahani, Siamak Beheshti, Mohammadreza Amirsadri, Faezeh Naseri, Mohammadjavad Keimasi, Najmeh Ghorbani, Mohammad Reza Mofid, Majid Moradmand   +11 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Sequestration of synaptic proteins by alpha-synuclein aggregates leading to neurotoxicity is inhibited by small peptide. [PDF]

PLoS ONE, 2018
α-Synuclein (α-syn) is a major component of Lewy bodies found in synucleinopathies including Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB).
Mal-Gi Choi, Mi Jin Kim, Do-Geun Kim, Ri Yu, You-Na Jang, Won-Jong Oh   +5 more
doaj   +1 more source