Results 11 to 20 of about 9,868 (165)

Synaptosomal- Associated Protein 25 Gene Polymorphisms and Antisocial Personality Disorder: Association with Temperament and Psychopathy [PDF]

Canadian Journal of Psychiatry, 2011
Objective: The molecular genetic of personality disorders has been investigated in several studies; however, the association of antisocial behaviours with synaptosomal-associated protein 25 (SNAP25) gene polymorphisms has not.
Kerim Munir, Mehmet Emin Erdal, Mesut Cetin   +2 more
exaly   +8 more sources

Integrative structural dynamics probing of the conformational heterogeneity in synaptosomal-associated protein 25. [PDF]

Cell Rep Phys Sci, 2021
SNAP-25 (synaptosomal-associated protein of 25 kDa) is a prototypical intrinsically disordered protein (IDP) that is unstructured by itself but forms coiled-coil helices in the SNARE complex. With high conformational heterogeneity, detailed structural dynamics of unbound SNAP-25 remain elusive.
Saikia N, Yanez-Orozco IS, Qiu R, Hao P, Milikisiyants S, Ou E, Hamilton GL, Weninger KR, Smirnova TI, Sanabria H, Ding F.   +10 more
europepmc   +3 more sources

Expression of synaptosomal-associated protein-25 in the rat brain after subarachnoid hemorrhage. [PDF]

Neural Regen Res, 2013
Synaptosomal-associated protein-25 is an important factor for synaptic functions and cognition. In this study, subarachnoid hemorrhage models with spatial learning disorder were established through a blood injection into the chiasmatic cistern. Immunohistochemical staining and western blot analysis results showed that synaptosomal-associated protein-25
Chen G, Hu T, Li Q, Li J, Jia Y, Wang Z.
europepmc   +3 more sources

Synaptosomal-associated protein 25 (Snap-25) gene polymorphism frequency in fibromyalgia syndrome and relationship with clinical symptoms. [PDF]

BMC Musculoskelet Disord, 2014
SNAP-25 protein is contributory to plasma membrane and synaptic vesicle fusions that are critical points in neurotransmission. SNAP-25 gene is associated with behavioral symptoms, personality and psychological disorders. In addition, SNAP-25 protein can be related to different neurotransmitter functions due to its association with vesicle membrane ...
Balkarli A, Sengül C, Tepeli E, Balkarli H, Cobankara V.   +4 more
europepmc   +7 more sources

Synaptosomal-Associated Protein 25 kDA (SNAP-25) Levels in Cerebrospinal Fluid: Implications for Alzheimer's Disease Diagnosis and Monitoring. [PDF]

Synapse
ABSTRACTSynaptic degeneration has been linked to cognitive decline. The presynaptic protein, synaptosomal‐associated protein 25 kDA (SNAP‐25), is crucial for synaptic transmission and has been suggested as a biomarker in Alzheimer's disease (AD). In the current study, we investigated the ability of SNAP‐25 to differentiate between heterogenous dementia
Wolner SH, Gleerup HS, Musaeus CS, Høgh P, Ashton NJ, Brinkmalm A, Nilsson J, Grötschel L, Zetterberg H, Blennow K, Hasselbalch SG, Walls AB, Simonsen AH.   +12 more
europepmc   +5 more sources

Synaptosomal-associated protein 25 mutation induces immaturity of the dentate granule cells of adult mice. [PDF]

Mol Brain, 2013
Abstract Background Synaptosomal-associated protein, 25 kDa (SNAP-25) regulates the exocytosis of neurotransmitters. Growing evidence suggests that SNAP-25 is involved in neuropsychiatric disorders, such as schizophrenia, attention-deficit/hyperactivity disorder, and epilepsy.
Ohira K, Kobayashi K, Toyama K, Nakamura HK, Shoji H, Takao K, Takeuchi R, Yamaguchi S, Kataoka M, Otsuka S, Takahashi M, Miyakawa T.   +11 more
europepmc   +4 more sources

Construction of a Yeast Cell-Based Assay System to Analyze SNAP25-Targeting Botulinum Neurotoxins

Microorganisms, 2023
Herein, we describe a yeast cell-based assay system to analyze SNAP25-targeting botulinum neurotoxins (BoNTs). BoNTs are protein toxins, and, upon incorporation into neuronal cells, their light chains (BoNT-LCs) target specific synaptosomal N ...
Shilin Chen, Feng Li, Guoyu Liu, Yuqing Li, Zijie Li, Yishi Liu, Hideki Nakanishi   +6 more
doaj   +1 more source

Phospholipase C-related but catalytically inactive protein (PRIP) modulates synaptosomal-associated protein 25 (SNAP-25) phosphorylation and exocytosis. [PDF]

J Biol Chem, 2012
Exocytosis is one of the most fundamental cellular events. The basic mechanism of the final step, membrane fusion, is mediated by the formation of the SNARE complex, which is modulated by the phosphorylation of proteins controlled by the concerted actions of protein kinases and phosphatases.
Gao J, Takeuchi H, Zhang Z, Fukuda M, Hirata M.   +4 more
europepmc   +4 more sources

Developmental expression of the 25-kDa synaptosomal-associated protein (SNAP-25) in rat brain. [PDF]

Proceedings of the National Academy of Sciences, 1991
The developmental expression and subcellular distribution of the neuron-specific 25-kDa synaptosomal protein (SNAP-25) were investigated by using Northern (RNA) blots, immunoblots, and immunocytochemistry. Both SNAP-25 protein and mRNA were present at low levels in embryonic day 15 rat brain, and levels of both increased during early postnatal ...
G A, Oyler, J W, Polli, M C, Wilson, M L, Billingsley   +3 more
openaire   +2 more sources

A single amino acid mutation in SNAP-25 induces anxiety-related behavior in mouse. [PDF]

PLoS ONE, 2011
Synaptosomal-associated protein of 25 kDa (SNAP-25) is a presynaptic protein essential for neurotransmitter release. Previously, we demonstrate that protein kinase C (PKC) phosphorylates Ser(187) of SNAP-25, and enhances neurotransmitter release by ...
Masakazu Kataoka, Saori Yamamori, Eiji Suzuki, Shigeru Watanabe, Taku Sato, Hitoshi Miyaoka, Sadahiro Azuma, Shiro Ikegami, Reiko Kuwahara, Rika Suzuki-Migishima, Yohko Nakahara, Itsuko Nihonmatsu, Kaoru Inokuchi, Yuko Katoh-Fukui, Minesuke Yokoyama, Masami Takahashi   +15 more
doaj   +1 more source