Results 1 to 10 of about 9,818 (128)

CSF levels of synaptosomal-associated protein 25 and synaptotagmin-1 in first-episode psychosis subjects [PDF]

IBRO Reports, 2020
Post-mortem studies consistently show evidence of reduced synaptic protein levels in patients with schizophrenia. Clinically high-risk subjects show a steeper decrease in grey matter thickness and in vitro modeling using patient-derived cells implicate ...
Chengai Xu, Carl M. Sellgren, Helena Fatouros-Bergman, Fredrik Piehl, Kaj Blennow, Henrik Zetterberg, Ann Brinkmalm, Alexander Frizell Santillo, Sofia Lundgren, Simon Cervenka, Göran Engberg, Sophie Erhardt   +11 more
doaj   +2 more sources

Synaptosomal-Associated Protein 25 Gene Polymorphisms Affect Treatment Efficiency of Methylphenidate in Children With Attention-Deficit Hyperactivity Disorder: An fNIRS Study [PDF]

Frontiers in Behavioral Neuroscience, 2022
Methylphenidate (MPH) is the first-line drug for the treatment of children with attention-deficit hyperactivity disorder (ADHD); however, individual curative effects of MPH vary.
Jie Li, Jie Li, Wen-Jie Yan, Yan Wu, Xin-Xin Tian, Yi-Wen Zhang   +5 more
doaj   +2 more sources

Mining the potential prognostic value of synaptosomal-associated protein 25 (SNAP25) in colon cancer based on stromal-immune score [PDF]

PeerJ, 2020
Background Colon cancer is one of the deadliest tumors worldwide. Stromal cells and immune cells play important roles in cancer biology and microenvironment across different types of cancer.
Jinyan Zou, Darong Duan, Changfa Yu, Jie Pan, Jinwei Xia, Zaixing Yang, Shasha Cai   +6 more
doaj   +3 more sources

Cerebrospinal fluid synaptosomal-associated protein 25 is a key player in synaptic degeneration in mild cognitive impairment and Alzheimer’s disease [PDF]

Alzheimer’s Research & Therapy, 2018
Background There is accumulating evidence that synaptic loss precedes neuronal loss and correlates best with impaired memory formation in Alzheimer’s disease (AD).
Hua Zhang, Joseph Therriault, Min Su Kang, Kok Pin Ng, Tharick A. Pascoal, Pedro Rosa-Neto, Serge Gauthier, the Alzheimer’s Disease Neuroimaging Initiative   +7 more
doaj   +2 more sources

Synaptosomal-associated protein 25 may be an intervention target for improving sensory and locomotor functions after spinal cord contusion [PDF]

Neural Regeneration Research, 2017
Synaptosomal-associated protein 25 kDa (SNAP-25) is localized on the synapse and participates in exocytosis and neurotransmitter release. Decreased expression of SNAP-25 is associated with Alzheimer's disease and attention deficit/hyperactivity disorder.
Zhan-qiong Zhong, Yang Xiang, Xi Hu, You-cui Wang, Xi Zeng, Xiao-meng Wang, Qing-jie Xia, Ting-hua Wang, Xiao Zhang   +8 more
doaj   +2 more sources

RTP004 Peptide Binds to Botulinum Neurotoxin, Increases Cell Surface Binding, and Enhances Cellular SNAP-25 Cleavage [PDF]

Toxins
DaxibotulinumtoxinA for injection (DAXI) is a botulinum neurotoxin (BoNT) drug product comprising the 150 kDa pure BoNT/A1 as the drug substance formulated with a proprietary stabilizing excipient, RTP004.
Andre F. Batista, Ratnesh Singh, Frank Lee, Shaoqiu Zhuo, Dmitri Leonoudakis, Conor J. Gallagher   +5 more
doaj   +2 more sources

Synaptic and cytoskeletal CSF signatures of motor neuron disease: the role of cyclase-associated protein 2 [PDF]

Scientific Reports
Cyclase-associated protein 2 (CAP2) is a synaptic actin-binding protein involved in cofilin-mediated spine remodelling, Alzheimer’s Disease synaptic failure and myofibril maintenance, indicating its potential involvement in motor neuron disease (MND ...
Andrea Pilotto, Silvia Pelucchi, Chiara Trasciatti, Lucia Ferullo, Loris Poli, Chiara Tolassi, Alberto Catanese, Irene Girotto, Beatrice Labella, Federica Gorla, Laura D’Andrea, Ramona Stringhi, Monica Di Luca, Elena Marcello, Alessandro Padovani   +14 more
doaj   +2 more sources

Presence of Cleaved Synaptosomal-Associated Protein-25 and Decrease of Purinergic Receptors P2X3 in the Bladder Urothelium Influence Efficacy of Botulinum Toxin Treatment for Overactive Bladder Syndrome. [PDF]

PLoS ONE, 2015
To evaluate whether botulinum toxin A (BoNT-A) injection and Lipotoxin (liposomes with 200 U of BoNT-A) instillation target different proteins, including P2X3, synaptic vesicle glycoprotein 2A, and SNAP-25, in the bladder mucosa, leading to different ...
Hsin-Tzu Liu, Sung-Ho Chen, Michael B Chancellor, Hann-Chorng Kuo   +3 more
doaj   +2 more sources

Evidence for reduced synaptic protein SNAP-25 in cerebrospinal fluid in major depressive disorder and schizophrenia [PDF]

BMJ Mental Health
Background Decreased cerebrospinal fluid (CSF) levels of synaptic proteins, possibly reflecting impaired synaptic function, have been observed in major depressive disorder (MDD).Objective To investigate the diagnostic utility of the soluble N ...
Patrick Oeckl, Petra Steinacker, Markus Otto, Steffen Halbgebauer, MHD Rami Al Shweiki, Samir Abu-Rumeileh, Naguib Mechawar, Carlos Schönfeldt-Lecuona, Lorenzo Barba, Leonie Werner, Alexander Tarabuko, Ilyas Al-Ali, Christopher R Pryce, Nadia Cattane, Giulia Poggi, Heiko Graf, Henning Großkopf, Laura Meier, Hugh Marston, Klaus D Bornemann, Bastian Hengerer, Karin M Danzer   +21 more
doaj   +2 more sources

CSF total tau as a proxy of synaptic degeneration [PDF]

Nature Communications
Cerebrospinal fluid (CSF) total tau (t-tau) is considered a biomarker of neuronal degeneration alongside brain atrophy and fluid neurofilament light chain protein (NfL) in biomarker models of Alzheimer’s disease (AD).
Carolina Soares, Bruna Bellaver, Pamela C. L. Ferreira, Guilherme Povala, Cristiano Schaffer Aguzzoli, João Pedro Ferrari-Souza, Hussein Zalzale, Firoza Z. Lussier, Francieli Rohden, Sarah Abbas, Guilherme Bauer-Negrini, Douglas Teixeira Leffa, Andréa Lessa Benedet, Rebecca Langhough, Tobey J. Betthauser, Bradley T. Christian, Rachael E. Wilson, Dana L. Tudorascu, Pedro Rosa-Neto, Thomas K. Karikari, Henrik Zetterberg, Kaj Blennow, Eduardo R. Zimmer, Sterling C. Johnson, Tharick A. Pascoal   +24 more
doaj   +2 more sources