Results 21 to 30 of about 9,868 (165)
Levels of Cortisol in CSF Are Associated With SNAP-25 and Tau Pathology but Not Amyloid-β
Frontiers in Aging Neuroscience, 2018 Objective: Preclinical studies have found both hyperactivity of hypothalamic- pituitary- adrenal (HPA) axis and synaptic degeneration are involved in the pathogenesis of Alzheimer’s disease (AD).
Qing Wang +3 more
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Detection of SNARE complexes with FRET using the tetracysteine system
BioTechniques, 2012 The three proteins synaptosomal-associated protein 25 (SNAP-25), Syntaxin-1a and vesicle-associated membrane protein (VAMP-2) are collectively called SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors).
Oleg Varlamov
doaj +1 more source
Scientific Reports, 2022 The interest for the discovery of blood biomarkers for several neurological disorders, including Ischemic Stroke (IS), is growing and their identification in blood samples would be revolutionary allowing a fast and better pathology prediction or outcome ...
Pamela Cappelletti +6 more
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Journal of Diabetes Research, 2016 A possible role of Snap25 polymorphisms in type 2 diabetes mellitus (T2DM) was evaluated by analyzing three SNPs within intron 1 in a region known to affect the gene expression in vitro. Genomic DNA from 1019 Saudi individuals (489 confirmed T2DM and 530
Nasser M. Al-Daghri +7 more
doaj +1 more source
Scientific Reports, 2021 Herein proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy was performed to achieve new potential targets for treating epileptic seizures.
Leila Sadeghi +10 more
doaj +1 more source
Alzheimer’s Research & Therapy, 2022 Background Synaptic dysfunction and degeneration are central to Alzheimer’s disease (AD) and have been found to correlate strongly with cognitive decline.
Johanna Nilsson +13 more
doaj +1 more source
Synaptic retrograde regulation of the PKA-induced SNAP-25 and Synapsin-1 phosphorylation
Cellular & Molecular Biology Letters, 2023 Background Bidirectional communication between presynaptic and postsynaptic components contribute to the homeostasis of the synapse. In the neuromuscular synapse, the arrival of the nerve impulse at the presynaptic terminal triggers the molecular ...
Aleksandra Polishchuk +9 more
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Cell Death and Disease, 2022 Gastric neuroendocrine carcinoma (GNEC), a heterogeneous group of neuroendocrine neoplasms (NENs) derived from gastric neuroendocrine cells, has been shown to be more aggressive and chemoresistant in gastric cancer, which contributes to the poor ...
Ziqi Lin, Hang Fai Kwok
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Cerebrospinal fluid biomarkers of Alzheimer's disease in a cohort of adults with Down syndrome
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020 Introduction Virtually all individuals with Down syndrome (DS) will develop Alzheimer's disease (AD) pathology by age 40. Cerebrospinal fluid (CSF) biomarkers have characterized AD pathology in cohorts of late‐onset AD (LOAD) and autosomal‐dominant AD ...
Rachel L. Henson +11 more
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Brain and Behavior, 2022 Introduction Attention deficit/hyperactivity disorder (ADHD) is a hereditary neurodevelopmental disorder characterized by working memory (WM) deficits.
Diangang Fang +7 more
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