Results 231 to 240 of about 38,926 (261)

Synaptotagmins: Beyond Presynaptic Neurotransmitter Release

The Neuroscientist, 2019
Synaptotagmins (Syts) are well-established primary Ca2+ sensors to initiate presynaptic neurotransmitter release. They also play critical roles in the docking, priming, and fusion steps of exocytosis, as well as the tightly coupled exo-endocytosis, in presynapses.
Xuanang Wu, Shaoqin Hu, Xinjiang Kang, Changhe Wang   +3 more
openaire   +2 more sources

Ca2+ Sensors: Synaptotagmins

2014
Synaptotagmin is a synaptic vesicle membrane protein that is postulated to function as a calcium (Ca2+) sensor for neurotransmitter release. This protein contains two Ca2+-binding domains (C2A, C2B) in its cytoplasmic region. Genetic studies provide strong evidence supporting the idea that synaptotagmin is the Ca2+ sensor for the fast synchronous ...
Tei-ichi Nishiki, Kentaro Kuroki, Toshio Masumoto, Hideki Matsui   +3 more
openaire   +1 more source

Synaptotagmin protein family

1994
Abstract The synaptotagmin protein family so far comprises two members in mammals (synaptotagmin I, GenBank accession number X52772, and synaptotagmin II, GenBank accession number M64499)12 and three members in the electric ray Discopyge ommata3 (GenBank accession numbers M64275, M64276, and M64277). In addition, a synaptotagmin cDNA was
R Jahn, T C Südhof
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Living synaptic vesicle marker: Synaptotagmin‐GFP

genesis, 2002
Synapses are the site of chemical communication between neurons and between neurons and muscles. The synaptic vesicle (SV) is a prominent presynaptic organelle which contains chemical neurotransmitters and fuses with the plasma membrane to mediate neurotransmission.
Yong Q, Zhang, Christopher K, Rodesch, Kendal, Broadie   +2 more
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Synaptotagmins bind calcium to release insulin

American Journal of Physiology-Endocrinology and Metabolism, 2008
Plasma insulin levels are determined mainly by the rate of exocytosis of the insulin-containing large dense core vesicles (LDCVs) of pancreatic islet β-cells. This process involves the recruitment of LDCVs to the plasma membrane, where they are docked by the assembly of multiprotein SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein ...
Gauthier, Benoît, Wollheim, Claes
openaire   +3 more sources

NGF Targets Synaptotagmin 4

Science Signaling, 2008
After neurons have received a depolarizing signal, the resulting influx of Ca 2+ triggers the fusion of secretory vesicles with the plasma membrane and the release of neurotransmitters. Neurotrophic factors such as nerve growth factor (NGF) enhance this process, although the mechanism responsible is not known. Mori
openaire   +1 more source

Synaptotagmin-SNARE coupling enlightened

Nature Structural & Molecular Biology, 2010
Synaptotagmins and SNAREs are known to couple Ca2+ sensing to membrane fusion during Ca2+-triggered exocytosis, but unraveling the mechanism of this coupling has proven extremely difficult. Two studies in this issue now provide crucial insights into the nature of synaptotagmin-SNARE interactions and reveal unsuspected similarities between ...
openaire   +1 more source

Effects and Mechanisms of Synaptotagmin-7 in the Hippocampus on Cognitive Impairment in Aging Mice

Molecular Neurobiology, 2021
Yaru Xie, Kaining Zhi, Xianfang Meng
semanticscholar   +1 more source

Synaptotagmin IV

Molecular Neurobiology, 2001
Harvey R. Herschman, Gregory D. Ferguson, Linda Vician   +2 more
openaire   +1 more source

Synaptotagmin

2006
openaire   +2 more sources