Results 81 to 90 of about 4,005 (212)

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source

Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD+ in axon regeneration. [PDF]

, 2018
The mechanisms underlying axon regeneration in mature neurons are relevant to the understanding of normal nervous system maintenance and for developing therapeutic strategies for injury.
Andrusiak, Matthew G, Cherra, Salvatore J, Chisholm, Andrew D, Jin, Yishi, Kim, Kyung Won, Kurup, Naina, Park, Seungmee, Piggott, Christopher A, Tang, Ngang Heok, Wu, Zilu, Zhu, Ming   +10 more
core   +1 more source

Different strokes for different synaptotagmins [PDF]

Journal of General Physiology, 2017
JGP study shows how synaptotagmins 1 and 7 affect chromaffin cell granule fusion.
openaire   +2 more sources

Postnatal developmental changes in the laryngeal chemosensory cell clusters of rats

Journal of Anatomy, EarlyView.
Chemosensory cell clusters appeared in the rat larynx 2 days after birth and were already connected to afferent nerve fibers. Their number increased until 3 weeks of age, then stabilized while continuing to grow through the addition of new cells. Because their number reached a plateau around the time of weaning, their development may be linked to ...
Sayed Sharif Abdali, Kanna Miyazaki, Takuya Yokoyama, Nobuaki Nakamuta, Tomoyuki Saino, Yoshio Yamamoto   +5 more
wiley   +1 more source

Neuronal calcium sensor synaptotagmin-9 is not involved in the regulation of glucose homeostasis or insulin secretion. [PDF]

PLoS ONE, 2010
BACKGROUND:Insulin secretion is a complex and highly regulated process. It is well established that cytoplasmic calcium is a key regulator of insulin secretion, but how elevated intracellular calcium triggers insulin granule exocytosis remains unclear ...
Natalia Gustavsson, Xiaorui Wang, Yue Wang, Tingting Seah, Jun Xu, George K Radda, Thomas C Südhof, Weiping Han   +7 more
doaj   +1 more source

COCHLEATA controls spatial regulation of cytokinin and auxin during nodule development

New Phytologist, EarlyView.
Nodule development defects in the coch mutant include root‐like structures, reduced colonisation, and vascular disorganisation. Summary Root nodules host nitrogen‐fixing bacteria and likely evolved through modifications of the lateral root program. Members of the NOOT‐BOP‐COCH‐LIKE transcriptional coregulator family suppress root identity in nodules ...
Karen Velandia, Muhammad Nouman Sohail, Tiana E. Scott, Alejandro Correa‐Lozano, Alannah Mannix, Eloise Foo   +5 more
wiley   +1 more source

C-terminal ECFP fusion impairs synaptotagmin 1 function: crowding out synaptotagmin 1.

The Journal of biological chemistry, 2005
To allow the monitoring of synaptotagmin 1 trafficking in vivo, we generated transgenic mice expressing a synaptotagmin 1-enhanced cyan fluorescent protein (ECFP) fusion protein under control of the Thy1 promoter. Transgenic synaptotagmin 1-ECFP is expressed throughout the brain where it localizes to synapses and marks synapses in vivo.
Han, W., Rhee, J., Maximov, A., Lin, W., Hammer, R., Rosenmund, C., Suedhof, T.   +6 more
openaire   +3 more sources

Genome Sequencing in 19 Families With Bladder Exstrophy and Epispadias Complex Indicates Involvement of the ADGR ‐Gene Family

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1286-1305, June 2026.
ABSTRACT Bladder exstrophy and epispadias complex (BEEC) is one of the most severe congenital malformations of the urogenital tract, significantly impacting continence, sexual function, and renal function. To date, the only recurrent genetic aberration identified is the 22q.11.2 microduplication, but several candidate regions and genes including ...
Agneta Nordenskjöld, Samara Alm, Jesper Eisfeldt, Jia Cao, Magnus Anderberg, Gillian Barker, Hans Matsson, Gundela Holmdahl, Anna Lindstrand, Kristina Lagerstedt‐Robinson   +9 more
wiley   +1 more source

Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts

eLife, 2019
Synaptophysins 1 and 2 and synaptogyrins 1 and 3 constitute a major family of synaptic vesicle membrane proteins. Unlike other widely expressed synaptic vesicle proteins such as vSNAREs and synaptotagmins, the primary function has not been resolved. Here,
Mathan K Raja, Julia Preobraschenski, Sergio Del Olmo-Cabrera, Rebeca Martinez-Turrillas, Reinhard Jahn, Isabel Perez-Otano, John F Wesseling   +6 more
doaj   +1 more source

Golgi apparatus-localized synaptotagmin 2 is required for unconventional secretion in Arabidopsis. [PDF]

PLoS ONE, 2011
BACKGROUND: Most secretory proteins contain signal peptides that direct their sorting to the ER and secreted via the conventional ER/Golgi transport pathway, while some signal-peptide-lacking proteins have been shown to export through ER/Golgi ...
Haiyan Zhang, Liang Zhang, Bin Gao, Hai Fan, Jingbo Jin, Miguel A Botella, Liwen Jiang, Jinxing Lin   +7 more
doaj   +1 more source