Results 91 to 100 of about 4,005 (212)

Plasma membrane lipid remodeling during cold acclimation is mediated by the ER-PM contact sites-localized synaptotagmins 1 and 3 [PDF]

, 2016
Cold acclimation is the capacity of certain plants to increase their freezing tolerance in response to a period of low non-freezing temperatures.
Botella-Mesa, Miguel Angel, Osorio-Algar, Sonia, Pérez-Sancho, Jessica, Rosado, Abel, Ruiz-Lopez, Noemi, Salinas, Julio, Schapire, Arnaldo, Vanneste, Steffen, Willtmitzer, Lothar   +8 more
core  

Stability, folding dynamics, and long-range conformational transition of the synaptic t-SNARE complex [PDF]

, 2016
Synaptic soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) couple their stepwise folding to fusion of synaptic vesicles with plasma membranes.
Jiao, J, Li, F, Ma, L, Pincet, F, Qu, H, Rebane, AA, Rothman, JE, Zhang, X, Zhang, Y   +8 more
core   +1 more source

Unveiling physiological functions of extended synaptotagmins [PDF]

Cell Cycle, 2015
The endoplasmic reticulum (ER) is an extensive membrane network in eukaryotic cells important for many cellular processes. To orchestrate cellular functions, the ER forms junctions with other organelles, where the 2 membranes are closely tethered by protein-lipid and/or protein-protein interactions within 10–25 nm.
Jen, Liou, Chi-Lun, Chang
openaire   +2 more sources

Identification of Alzheimer's disease subtypes and biomarkers from human multi‐omics data using subspace merging algorithm

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) is a heterogeneous disease with diverse disease progression trajectories and brain pathology. Identifying AD subtypes is essential for understanding AD etiology, heterogeneity, and developing precise treatment. METHODS We applied a subspace‐merging algorithm to integrate multi‐omics data from brain tissues
Ziyan Song, Xiaoqing Huang, Asha Jacob Jannu, Travis S. Johnson, Jie Zhang, Kun Huang   +5 more
wiley   +1 more source

Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses [PDF]

, 2017
Hearing relies on rapid, temporally precise, and sustained neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (IHCs).
Auclair, SM, Avan, P, Bahloul, A, Ciric, D, de Monvel, JB, Dulon, D, Emptoz, A, Goutman, JD, Guillon, M, Hardelin, J-P, Krishnakumar, SS, Michalski, N, Nouaille, S, Parrin, A, Petit, C, Rothman, JE, Sachse, M, Safieddine, S, Sutton, RB, Tertrais, M   +19 more
core   +1 more source

SYT13: An underestimated synaptotagmin

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Synaptotagmin-13 (SYT13) is a non-canonical member of the of synaptotagmin family that, canonical synaptotagmins, doesn't contain Ca2+ binding sites, but still appears to play a key role in the control of different cellular processes such as vesicle transport, cell migration, signaling and cell development.
Lehmann, Johannes, Catanese, Alberto
openaire   +2 more sources

Impact of organic pollutants on phenotype and gene expression in human breast cancer cells

Journal of Applied Toxicology, Volume 46, Issue 5, Page 1487-1505, May 2026.
ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin, Heloisa Amancio, Jessica Zablocki da Luz, Aliciane de Almeida Roque, Tugstênio Lima de Souza, José Eduardo Vargas, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +7 more
wiley   +1 more source

HID-1 controls formation of large dense core vesicles by influencing cargo sorting and trans-Golgi network acidification [PDF]

, 2017
Large dense core vesicles (LDCVs) mediate the regulated release of neuropeptides and peptide hormones. They form at the trans-Golgi network (TGN), where their soluble content aggregates to form a dense core, but the mechanisms controlling biogenesis are ...
Asensio, Cedric S, Burns, Christian, Chen, Lan, de Leeuw, Noah F, Fitzpatrick, James A. J., Hosford, Bethany, Hummer, Blake H, Joens, Matthew S   +7 more
core   +2 more sources

Reduction in Synaptic Vesicle Protein Abundance but Increased Amounts of Nsg2 and Lpcat1 in Cerebral Cortices Without the Endosomal SNARE Proteins Vti1a and Vti1b

PROTEOMICS, Volume 26, Issue 5, Page 86-97, May 2026.
ABSTRACT Absence of the endosomal SNAREs vti1a and vti1b results in perinatal death and severe neuronal phenotypes in mice, while lack of one of these proteins results in minor phenotypes. Proteomic differences were investigated to obtain a deeper insight into processes in which vti1a and vti1b are involved.
Julia Gottschalk, Katharina Kotschnew, Julia Hahn, Thomas Patschkowski, Gabriele von Fischer von Mollard   +4 more
wiley   +1 more source

Evolution of complexity in the zebrafish synapse proteome [PDF]

, 2017
The proteome of human brain synapses is highly complex and mutated in over 130 diseases. This complexity arose from two whole genome duplications early in the vertebrate lineage.
A Bayés, A Bayés, A Bayés, A Bayés, A Force, AM Stewart, AV Kalueff, D Cheng, DC Dieterich, DS Kelkar, E Fernandez, F Antonucci, F Cunningham, G Kirov, GA Watterson, H Ito, H Mi, H Nolte, H Wang, HJK Balderhaar, HY Wang, I Braasch, J Cox, J Cox, J Meek, J Nithianantharajah, J Peng, J Rizo, J Schindelin, J Zhou, JA Morris, JA Vizcaíno, JC Darnell, JC Trinidad, JH Hurley, K Howe, K Li, KM Harris, L Huminiecki, M Focking, M Fromer, M Ichikawa, M Kanehisa, M Kasahara, M Laufer, M-S Kim, MC Whitman, N Brose, R Chassefeyre, RD Emes, RD Emes, RD Lund, S Durinck, S Hussain, S Jurado, S Tyanova, SB Hedges, SE Calvano, SG Grant, SG Grant, TJ Ryan, TM Fonseka, U Distler, VT Cunliffe, X Han, Y Nishimura, Y Oka, Y Wang, Y Xi, YH Suh   +69 more
core   +4 more sources