Results 111 to 120 of about 4,005 (212)

Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy. [PDF]

, 2017
Transverse (T)-tubules make-up a specialized network of tubulated muscle cell membranes involved in excitation-contraction coupling for power of contraction. Little is known about how T-tubules maintain highly organized structures and contacts throughout
Fujita, Naonobu, Fukuda, Mitsunori, Groulx, Jean-Francois, Huang, Wilson, Jean, Steve, Kiger, Amy A, Koyama-Honda, Ikuko, Kuchitsu, Yoshihiko, Lin, Tzu-Han, Mizushima, Noboru, Nguyen, Jen   +10 more
core   +2 more sources

Genomic Analysis of Synaptotagmin Genes

Genomics, 2001
I used TBLASTn to probe DNA sequence databases with a consensus peptide sequence corresponding to the most highly conserved region of the rodent synaptotagmin (Syt) gene family, which is within the C2B domain. I found human homologues for all known rodent genes, and found six further human genomic loci which encode potential family members.
openaire   +2 more sources

Beyond the MUN domain, Munc13 controls priming and depriming of synaptic vesicles

Cell Reports
Summary: Synaptic vesicle docking and priming are dynamic processes. At the molecular level, SNAREs (soluble NSF attachment protein receptors), synaptotagmins, and other factors are critical for Ca2+-triggered vesicle exocytosis, while disassembly ...
Jeremy Leitz, Chuchu Wang, Luis Esquivies, Richard A. Pfuetzner, John Jacob Peters, Sergio Couoh-Cardel, Austin L. Wang, Axel T. Brunger   +7 more
doaj   +1 more source

Upregulation of synaptotagmin IV inhibits transmitter release in PC12 cells with targeted synaptotagmin I knockdown

BMC Neuroscience, 2010
Background The function of synaptotagmins (syt) in Ca2+-dependent transmitter release has been attributed primarily to Ca2+-dependent isoforms such as syt I.
Moore-Dotson Johnnie M, Papke Jason B, Harkins Amy B   +2 more
doaj   +1 more source

Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function [PDF]

, 2018
Loss of functional β-cell mass is an early feature of type 1 diabetes. To release insulin, β-cells require soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes, as well as SNARE complex regulatory proteins like double ...
Ahn, Miwon, Aslamy, Arianne, Moin, Abu Saleh Md, Oh, Eunjin, Olson, Erika M., Salunkhe, Vishal A., Thurmond, Debbie C., Tunduguru, Ragadeepthi, Veluthakal, Rajakrishnan, Zhang, Jing   +9 more
core   +1 more source

Synaptotagmin 4: A New Antiobesity Target? [PDF]

Neuron, 2011
In this issue of Neuron, Zhang et al. show that Synaptotagmin 4 (Syt4) is specifically induced in adult hypothalamic oxytocin neurons by high-fat diet. Evidence is provided to support a critical role for Syt4 in negative regulation of oxytocin release, which in turn is responsible for diet-induced obesity, raising the possibility of using Syt4 as a new
openaire   +2 more sources

Analysis of the hippocampal proteome in ME7 prion disease reveals a predominant astrocytic signature and highlights the brain-restricted production of clusterin in chronic neurodegeneration

, 2013
Prion diseases are characterized by accumulation of misfolded protein, gliosis, synaptic dysfunction, and ultimately neuronal loss. This sequence, mirroring key features of Alzheimer disease, is modeled well in ME7 prion disease.
Asuni, Ayodeji A, Bailey, Joanne, Gray, Bryony, O'Connor, Vincent, Perry, V Hugh, Skipp, Paul   +5 more
core   +1 more source

Protein kinase C iota facilitates insulin‐induced glucose transport by phosphorylation of soluble nSF attachment protein receptor regulator (SNARE) double C2 domain protein b

Journal of Diabetes Investigation, 2019
Aims/introduction Double C2 domain protein b (DOC2b), one of the synaptotagmins, has been shown to translocate to the plasma membrane, and to initiate membrane‐fusion processes of vesicles containing glucose transporter 4 proteins on insulin stimulation.
Ryuta Nomiyama, Masahiro Emoto, Naofumi Fukuda, Kumiko Matsui, Manabu Kondo, Ayuko Sakane, Takuya Sasaki, Yukio Tanizawa   +7 more
doaj   +1 more source

Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins. [PDF]

, 2020
Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed. Single-domain antibodies (VHH) have been examined as a countermeasure for BoNT because of their high ...
Jin, Rongsheng, Lam, Kwok-Ho, McNutt, Patrick M, Ondeck, Celinia, Perry, Kay, Shoemaker, Charles B, Tremblay, Jacqueline M, Vazquez-Cintron, Edwin, Webb, Robert P   +8 more
core  

Regulation of Exocytotic Fusion Pores by SNARE Protein Transmembrane Domains

Frontiers in Molecular Neuroscience, 2017
Calcium-triggered exocytotic release of neurotransmitters and hormones from neurons and neuroendocrine cells underlies neuronal communication, motor activity and endocrine functions.
Zhenyong Wu, Zhenyong Wu, Sathish Thiyagarajan, Ben O’Shaughnessy, Erdem Karatekin, Erdem Karatekin, Erdem Karatekin, Erdem Karatekin   +7 more
doaj   +1 more source