Results 1 to 10 of about 11,302 (215)
Low Soluble Syndecan-1 Precedes Preeclampsia [PDF]
PLOS ONE, 2016 Syndecan-1 (Sdc1; CD138) is a major transmembrane heparan sulfate proteoglycan expressed on the extracellular, luminal surface of epithelial cells and syncytiotrophoblast, thus comprising a major component of the glycocalyx of these cells. The "soluble" (shed) form of Sdc1 has paracrine and autocrine functions and is normally produced in a regulated ...
Gandley, RE +8 more
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Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies [PDF]
Scientific Reports, 2021 Preeclampsia, an important cause of maternal and fetal morbidity and mortality, is associated with increased sFLT1 levels and with structural and functional damage to the glycocalyx contributing to endothelial dysfunction.
H. Hassani Lahsinoui +9 more
doaj +3 more sources
Distribution of syndecan-1 protein in developing mouse teeth [PDF]
Frontiers in Physiology, 2015 Syndecan-1 is a cell surface proteoglycan involved in the regulation of various biological processes such as proliferation, migration, condensation and differentiation of cells, intercellular communication and morphogenesis.
Anna eFilatova +2 more
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Heparanase regulates levels of syndecan-1 in the nucleus. [PDF]
PLoS ONE, 2009 Syndecan-1 is a transmembrane heparan sulfate-bearing proteoglycan known to regulate multiple biological functions at the cell surface and within the extracellular matrix.
Ligong Chen, Ralph D Sanderson
doaj +5 more sources
A novel role for syndecan-3 in angiogenesis [v1; ref status: indexed, http://f1000r.es/2g6] [PDF]
F1000Research, 2013 Syndecan-3 is one of the four members of the syndecan family of heparan sulphate proteoglycans and has been shown to interact with numerous growth factors via its heparan sulphate chains.
Giulia De Rossi, James R. Whiteford
doaj +5 more sources
Biochemistry and Biophysics Reports, 2021 Syndecan-1 and syndecan-4 are members of the syndecan family of transmembrane heparan sulfate proteoglycans. Vascular endothelial cells synthesize both species of proteoglycans and use them to regulate the blood coagulation-fibrinolytic system and their ...
Takato Hara +3 more
doaj +1 more source
Syndecan-1 enhances proliferation, migration and metastasis of HT-1080 cells in cooperation with syndecan-2. [PDF]
PLoS ONE, 2012 Syndecans are transmembrane heparan sulphate proteoglycans. Their role in the development of the malignant phenotype is ambiguous and depends upon the particular type of cancer.
Bálint Péterfia +11 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2021 Background: Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host responses to infection. Recent studies have suggested that endotheliopathy may be the common basis for multiple organ failure in sepsis.
Kosaku Hatanaka +7 more
doaj +1 more source
Syndecan-1 in Liver Diseases [PDF]
Pathology & Oncology Research, 2019 Liver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on the surfaces of hepatocytes and cholangiocytes. Due to liver diseases the amount of syndecan-1 increases in the liver.
Regős E +6 more
openaire +4 more sources
Focus on Molecules: Syndecan-1 [PDF]
Experimental Eye Research, 2011 Syndecan-1 (NP_001006947.1) is a widely expressed cell surface heparan sulfate proteoglycan whose molecular cloning as ‘syndecan’ (Saunders et al, ’89), later known as syndecan-1, was the springboard for the discovery of syndecans-2 through -4. Expression in the eye has been documented in corneal, limbal (GDS2433) and conjunctival epithelial cells ...
Alan C. Rapraeger +4 more
openaire +3 more sources