Results 91 to 100 of about 24,713 (214)

Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity

Advanced Science, EarlyView.
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng, Zhe Lei, Zhehao Zhang, Zhiyue Su, Chonghai Zhang, Huan Yang, Shu Liu, Mengyuan Hu, Yuhong Wang, Lingchuan Guo, Lin Hu, Kai Yang   +11 more
wiley   +1 more source

Temporal glomerular gene expression dynamics during disease progression in a mouse model of hypertension‐accelerated diabetic kidney disease

Animal Models and Experimental Medicine, EarlyView.
The current study characterized temporal changes in glomerular gene expression, pathology, and biomarkers in a mouse model of hypertension‐accelerated diabetic kidney disease (DKD). Progressive albuminuria and glomerulosclerosis were paralleled by dynamic transcriptomic changes associated withmetabolic dysfunction, extracellular matrix remodeling, and ...
Adam B. Marstrand‐Jørgensen, Frederikke Emilie Sembach, Maria Ougaard, Ditte Hansen, Mette Viberg Østergaard, Henrik H. Hansen, Louise S. Dalbøge, Ole Jørgen Kaasbøll, Michael Christensen   +8 more
wiley   +1 more source

Syndecan-1-Induced ECM Fiber Alignment Requires Integrin αvβ3 and Syndecan-1 Ectodomain and Heparan Sulfate Chains

PLOS ONE, 2016
Expression of the cell surface proteoglycan syndecan-1 (Sdc1) is frequently induced in stromal fibroblasts of invasive breast carcinomas. We have recently identified a correlation between stromal Sdc1 expression and extracellular matrix (ECM) fiber alignment, both in vitro and in vivo.
Ning Yang, Andreas Friedl
openaire   +4 more sources

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, EarlyView.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify noninvasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, for the Lupus Nephritis Classification Steering Committee   +11 more
wiley   +1 more source

Heparanase regulates levels of syndecan-1 in the nucleus. [PDF]

PLoS ONE, 2009
Syndecan-1 is a transmembrane heparan sulfate-bearing proteoglycan known to regulate multiple biological functions at the cell surface and within the extracellular matrix.
Ligong Chen, Ralph D Sanderson
doaj   +1 more source

Specific genes involved in synthesis and editing of heparan sulfate proteoglycans show altered expression patterns in breast cancer [PDF]

, 2013
This work was supported in part by the Instituto de Salud Carlos III-Fondo de Investigación Sanitaria (grant PI051564).
Astudillo González, María Aurora, Castañón, S., Crespo, A., Fernández Vega, Iván, García Suárez, Olivia, Menéndez Rodríguez, María Primitiva, Quirós Fernández, Luis Manuel   +6 more
core   +1 more source

Integrative single cell RNA‐sequencing and spatial transcriptomics uncovers distinct macrophage‐fibroblast cross‐talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objectives Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell‐cell interactions in FAI and hip OA.
Gulzada Kulzhanova, Alexis Klee, Mina Botros, Victoria L. Hansen, John Reuter, Eliya Tazreena Tashbib, Eloise Fadial, Benjamin F. Ricciardi, Brian Giordano, Chia‐Lung Wu   +9 more
wiley   +1 more source

Syndecan-1-Dependent Regulation of Heparanase Affects Invasiveness, Stem Cell Properties, and Therapeutic Resistance of Caco2 Colon Cancer Cells

Frontiers in Oncology, 2020
The heparan sulfate proteoglycan Syndecan-1 binds cytokines, morphogens and extracellular matrix components, regulating cancer stem cell properties and invasiveness.
Sampath Kumar Katakam, Paride Pelucchi, Cinzia Cocola, Rolland Reinbold, Israel Vlodavsky, Burkhard Greve, Martin Götte   +6 more
doaj   +1 more source

Chapter Five. Systematic review results by biomarker classifications [PDF]

, 2016
5.1 Markers of Absorption and Permeability Overview 5.2 Markers of Absorption 5.3 Markers of Permeability 5.4 Markers of Digestion 5.5 Markers of Intestinal Inflammation and Intestinal Immune Activation 5.6 Markers of Systemic Inflammation and Systemic ...
Denno, Donna M, Musser, Christine A, Nelson, Zakia C, Tarr, Phillip I, VanBuskirk, Kelley M   +4 more
core   +1 more source

Comparative histological and immunohistochemical study of ameloblastomas and ameloblastic carcinomas [PDF]

, 2017
This study aimed to compare the histological and immunohistochemical characteristics of ameloblastomas (AM) and ameloblastic carcinomas (AC). Fifteen cases of AM and 9 AC were submitted to hematoxilin and eosin and immunohistochemical analysis with the ...
Aldape Barrios, B., Almeida, Oslei Paes de, Carlos, Román, Delagado Azañero, Wilson, Martinez-Martinez, Marisol, Mosqueda Taylor, Adalberto, Neves-Silva, Rodrigo, Pires, Fábio-Ramôa   +7 more
core   +1 more source