Results 91 to 100 of about 11,302 (215)

Neuronal THY1 Signaling Maintains Astrocytes in a Quiescent State

Glia, EarlyView.
THY1‐bearing neurons keep astrocytes in a quiescent state via the interaction with ITGB1. Depletion of THY1 supports the development of a partially activated astrocyte phenotype. Neuronal THY1 is involved in the maintenance and restoration of tissue homeostasis in the brain. ABSTRACT THY1 is a cell surface protein of mature neurons.
Juliane Loui, Ute Krügel, Ulrike Winkler, Anja Reinert, Dorit John, Johannes Hirrlinger, Anja Saalbach   +6 more
wiley   +1 more source

Syndecan-1: a dynamic regulator of the myeloma microenvironment [PDF]

Clinical & Experimental Metastasis, 2007
Emerging data in myeloma and other cancers indicates that heparan sulfate proteoglycans promote tumor progression by enhancing their growth and metastasis. By acting as key regulators of cell signaling via their interactions with multiple growth and angiogenic factors, heparan sulfates mediate a shift in the microenvironment that supports the tumor as ...
Yang Yang, Ralph D. Sanderson
openaire   +3 more sources

Impact of Systemic Lupus Erythematosus (SLE) on Short‐Term Outcomes of Cholecystectomy for Acute Cholecystitis: An Analysis of the US National Readmission Database, 2016–2020

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background/Purpose Systemic lupus erythematosus (SLE) may impact surgical outcomes of acute cholecystitis due to immune dysfunction and systemic inflammation. This study evaluated short‐term outcomes of cholecystectomy in SLE patients using US Nationwide Readmissions Database data.
Shao Ciao Luo, Kuei‐Heng Chang, Te‐Cheng Su, He‐Yuan Hsieh, Yu‐Hsuan Shih, Hsin‐Chen Lin, Ming‐Chih Chou   +6 more
wiley   +1 more source

Serum Syndecan-1 is Associated With Kidney and Cardiovascular Outcomes in Idiopathic Nephrotic Syndrome

Kidney International Reports
Introduction: Idiopathic nephrotic syndrome (INS) is associated with important kidney and cardiovascular morbidities. We tested the hypothesis that serum syndecan-1, a marker of endothelial glycocalyx injury, can help identify patients at risk for ...
Colin Bauer, Arshia Anand, Christine Sethna, Jonathan Troost, Tarak Srivastava, Imtiazul Islam, Audrey Fetsko, Julie A. Dougherty, William E. Smoyer, Richard J. Johnson, Gabriel Cara-Fuentes   +10 more
doaj   +1 more source

The Role of Syndecan‐1 in Arterial Mechanotransduction

The FASEB Journal, 2010
Hemodynamic forces induced by blood flow are potent regulators of vascular homeostasis and arterial structure. While previous work has focused on the role of integrin receptors in mechanotransduction, little is known about the role of cell surface proteoglycans in these processes.
Aaron B Baker, Vipul Chitalia, Benjamin G Steyer, Sameer Hirji, Elazer R Edelman   +4 more
openaire   +2 more sources

Specific genes involved in synthesis and editing of heparan sulfate proteoglycans show altered expression patterns in breast cancer [PDF]

, 2013
This work was supported in part by the Instituto de Salud Carlos III-Fondo de Investigación Sanitaria (grant PI051564).
Astudillo González, María Aurora, Castañón, S., Crespo, A., Fernández Vega, Iván, García Suárez, Olivia, Menéndez Rodríguez, María Primitiva, Quirós Fernández, Luis Manuel   +6 more
core   +1 more source

Breast Milk Proteome: Changes in the Different Stages of Lactation and Impacts of Gestational Diabetes Mellitus and Body Mass Index

Molecular Nutrition &Food Research, EarlyView.
We analyzed colostrum and breast milk from 47 mothers to see how proteins change over time and with maternal health. Colostrum had more immune proteins, while mature milk had proteins linked to growth support. Gestational diabetes and higher BMI altered the protein composition.
Timo Seitz, Jenni Viitaharju, Chouaib Benchraka, Johannes Merilahti, Marko Kalliomäki, Lauri Polari, Diana Toivola, Leo Lahti, Otto Kauko, Kirsi Laitinen   +9 more
wiley   +1 more source

Immunohistochemical analysis of syndecan-1 in leukoplakia and oral submucous fibrosis

Dental Research Journal, 2013
Background: Syndecan-1 is abundant in normal tissues and reduced in squamous cell carcinomas. Leukoplakia and oral submucous fibrosis (OSF) are oral pre-cancerous disorders that have potential for malignant transformation.
Sushant S Kamat, G S Kumar, Ajit V Koshy
doaj   +1 more source

Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria

Scientific Reports, 2021
Fetal growth restriction is a leading cause of stillbirth that often remains undetected during pregnancy. Identifying novel biomarkers may improve detection of pregnancies at risk.
Damanpreet Garcha, Susan P. Walker, Teresa M. MacDonald, Jon Hyett, Jessica Jellins, Jenny Myers, Sebastian E. Illanes, Jhy K. Nien, Manuel Schepeler, Emerson Keenan, Carole-Anne Whigham, Ping Cannon, Elizabeth Murray, Tuong-Vi Nguyen, Manju Kandel, Joshua Masci, Ciara Murphy, Tess Cruickshank, Natasha Pritchard, Natalie J. Hannan, Fiona Brownfoot, Alexandra Roddy Mitchell, Anna Middleton, Gabrielle Pell, Georgia P. Wong, Stephen Tong, Tu’uhevaha J. Kaitu’u-Lino   +26 more
doaj   +1 more source

Hepatitis C virus relies on lipoproteins for its life cycle [PDF]

, 2016
Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma.
Alonzi, Tonino, DI CAPRIO, Giorgia, Fimia, Gian Maria, Grassi, Germana, Ippolito, Giuseppe, Tripodi, Marco   +5 more
core   +1 more source