Results 181 to 190 of about 107,687,715 (215)
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Syndecan-1 in B lymphoid malignancies
Annals of Hematology, 2002Syndecans are heparan sulfate-bearing proteoglycans that are found on the surface of most cells. Syndecan-1 is expressed predominantly on epithelia, but is also present on pre-B cells and plasma cells. The syndecans act to bind various effector molecules via their heparan sulfate chains, including both soluble and insoluble molecules within the ...
R D, Sanderson, M, Børset
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Impaired arteriogenesis in syndecan-1−/− mice
Journal of Surgical Research, 2015Collateral artery development (arteriogenesis) is an important compensatory response to arterial occlusion caused by atherosclerosis. The heparan sulfate proteoglycan syndecan-1 (sdc1) has previously been shown to affect the response to arterial injury but has yet been studied in arteriogenesis.
Gale L, Tang, Kevin, Weitz
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Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2012
To construct the expressing vector pcDNA3.0- wildtype-syndecan-1(WT-sdc1) and pcDNA3.0-unshedding-syndecan-1(uS-sdc1), and to explore the expression in vitro.(1)The mouse WT-sdc1 DNA was successfully amplified by PCR and then cloned into pcDNA3.0. uS-sdc1 was construct by Gene splicing by overlap extension- PCR on the basis of WT-sdc1.
Jun, Liu +7 more
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To construct the expressing vector pcDNA3.0- wildtype-syndecan-1(WT-sdc1) and pcDNA3.0-unshedding-syndecan-1(uS-sdc1), and to explore the expression in vitro.(1)The mouse WT-sdc1 DNA was successfully amplified by PCR and then cloned into pcDNA3.0. uS-sdc1 was construct by Gene splicing by overlap extension- PCR on the basis of WT-sdc1.
Jun, Liu +7 more
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Syndecan-1 in the Tumor Microenvironment
2020Syndecan-1 along with the other three syndecan proteins is present in the varied components of the tumor microenvironment: fibroblasts, inflammatory tumor immunity-associated cells, vessels, and extracellular matrix. Epithelial and non-epithelial tumors may show stromal syndecans.
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Involvement of Syndecan-1 and Heparanase in Cancer and Inflammation
2020The cell surface heparan sulfate proteoglycan Syndecan-1 acts as an important co-receptor for receptor tyrosine kinases and chemokine receptors, and as an adhesion receptor for structural glycoproteins of the extracellular matrix. It serves as a substrate for heparanase, an endo-β-glucuronidase that degrades specific domains of heparan sulfate ...
Felipe C O B, Teixeira, Martin, Götte
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Altered expression of syndecan‐1 in prostate cancer
APMIS, 2004Syndecan‐1 is a cell surface heparan sulfate proteoglycan expressed by epithelial cells. It interacts with growth factors, matrix components, and other extracellular proteins, and is thought to be involved in processes such as cell growth, differentiation and adhesion. The expression of syndecan‐1 appears generally downregulated in human carcinomas and
Johanna, Kiviniemi +6 more
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Syndecan-1 expression in laryngeal cancer
European Archives of Oto-Rhino-Laryngology, 2002Syndecan-1 is a member of the syndecan family of cell surface heparan sulphate proteoglycans. The aim of this study was the evaluation of syndecan-1 expression in laryngeal cancer. The findings were correlated both with the clinico-pathological parameters of the tumours and with patient survival.
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Placental expression of syndecan 1 is diminished in preeclampsia
American Journal of Obstetrics and Gynecology, 2000Syndecan 1 is a cell surface heparan sulfate proteoglycan that binds growth factors and antithrombin III. The objective of this study was to examine whether placental expression of syndecan 1 in preeclampsia differs from that in normal pregnancy and whether gestational age and fetal growth affect syndecan 1 expression.An immunohistochemical analysis of
V I, Jokimaa +4 more
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Expression of syndecan-1 in human placenta and decidua
Placenta, 1998Syndecan-1 is a cell surface heparan sulphate proteoglycan, which binds to the extracellular matrix (ECM), growth factors and antithrombin III. The early expression of syndecan-1 during mouse embryonic development suggests a potential role in the communication between the embryo and the ECM of decidua.
V, Jokimaa +5 more
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