Results 21 to 30 of about 11,302 (215)

Glycobiology of syndecan-1 in bacterial infections [PDF]

Biochemical Society Transactions, 2018
Syndecan-1 (Sdc1) is a major cell surface heparan sulfate (HS) proteoglycan of epithelial cells, a cell type targeted by many bacterial pathogens early in their pathogenesis. Loss of Sdc1 in mice is a gain-of-function mutation that significantly decreases the susceptibility to several bacterial infections, suggesting that subversion of Sdc1 is an ...
Yvonne Hui-Fang Teng, Pyong Woo Park, Rafael S. Aquino   +2 more
openaire   +2 more sources

Association of loss of epithelial syndecan-1 with stage and local metastasis of colorectal adenocarcinomas: An immunohistochemical study of clinically annotated tumors

BMC Cancer, 2008
Background Syndecan-1 is a transmembrane proteoglycan with important roles in cell-cell and cell-extracellular matrix adhesion and as a growth factor co-receptor.
Skacel Marek, Hashimoto Yosuke, Adams Josephine C   +2 more
doaj   +1 more source

Measuring the Concentration of Serum Syndecan-1 to Assess Vascular Endothelial Glycocalyx Injury During Hemodialysis

Frontiers in Medicine, 2021
Glycocalyx is present on the surface of healthy endothelium, and the concentration of serum syndecan-1 can serve as an injury marker. This study aimed to assess endothelial injury using serum syndecan-1 as a marker of endothelial glycocalyx injury in ...
Keigo Kusuzawa, Keiko Suzuki, Hideshi Okada, Kodai Suzuki, Chihiro Takada, Soichiro Nagaya, Ryu Yasuda, Haruka Okamoto, Takuma Ishihara, Hiroyuki Tomita, Yuki Kawasaki, Toru Minamiyama, Ayane Nishio, Hirotsugu Fukuda, Takuto Shimada, Yuto Tamaoki, Tomoki Yoshida, Yusuke Nakashima, Naokazu Chiba, Genki Yoshimura, Ryo Kamidani, Tomotaka Miura, Tomotaka Miura, Hideaki Oiwa, Hideaki Oiwa, Fuminori Yamaji, Yosuke Mizuno, Takahito Miyake, Yuichiro Kitagawa, Tetsuya Fukuta, Tomoaki Doi, Akio Suzuki, Takahiro Yoshida, Nobuyuki Tetsuka, Shozo Yoshida, Shozo Yoshida, Shinji Ogura   +36 more
doaj   +1 more source

Inhibition by the Soluble Syndecan-1 Ectodomains Delays Wound Repair in Mice Overexpressing Syndecan-1 [PDF]

Journal of Biological Chemistry, 2004
Wound repair is a tightly regulated process stimulated by proteases, growth factors, and chemokines, which are modulated by heparan sulfate. To characterize further the role of the heparan sulfate proteoglycan syndecan-1 in wound repair, we generated mice overexpressing syndecan-1 (Snd/Snd) and studied dermal wound repair.
Merton Bernfield, Ofer Reizes, Ofer Reizes, Martin Götte, Martin Götte, Klaus Elenius, Klaus Elenius, Varpu Elenius, Varpu Elenius, Varpu Elenius   +9 more
openaire   +3 more sources

S-maltoheptaose targets syndecan-bound effectors to reduce smoking-related neutrophilic inflammation. [PDF]

, 2015
Cigarette smoke induces injury and neutrophilic inflammation in the airways of smokers. The stability and activity of inflammatory effectors, IL8 and neutrophil elastase (NE), can be prolonged by binding to airway heparan sulfate (HS)/syndecan-1, posing ...
Chan, CH, Freeman, C, Ip, MSM, Lam, CLD, Mak, JCW, Shum, DKY   +5 more
core   +1 more source

Aberrant Expression of Syndecan-1 in Cervical Cancers [PDF]

Pathology & Oncology Research, 2020
Syndecan-1, is a transmembrane heparan/chondroitin sulfate proteoglycan necessary for cell-cell and cell-matrix interactions. Its decreased level on the cell surface correlates with poor prognosis in several tumor types. Aberrant stromal localization of syndecan-1 is also considered an unfavorable prognostic factor in various human malignancies. In the
Katalin Karászi, Renáta Vigh, Miklós Máthé, Alexandra Fullár, Lászlóné Oláh, Tibor Füle, Zoltán Papp, Ilona Kovalszky   +7 more
openaire   +2 more sources

Heparinase selectively sheds heparan sulphate from the endothelial glycocalyx [PDF]

, 2008
A healthy vascular endothelium is coated by the endothelial glycocalyx. Its main constituents are transmembrane syndecans and bound heparan sulphates. This structure maintains the physiological endothelial permeability barrier and prevents leukocyte and ...
Becker, Bernhard F., Chappell, Daniel, Conzen, Peter, Jacob, Matthias, Rehm, Markus, Stoeckelhuber, Mechthild, Welsch, Ulrich   +6 more
core   +1 more source

Syndecan-1 in the mouse parietal peritoneum microcirculation in inflammation. [PDF]

PLoS ONE, 2014
BACKGROUND: The heparan sulfate proteoglycan syndecan-1 (CD138) was shown to regulate inflammatory responses by binding chemokines and cytokines and interacting with adhesion molecules, thereby modulating leukocyte trafficking to tissues.
Paulina M Kowalewska, Amanda L Patrick, Alison E Fox-Robichaud   +2 more
doaj   +1 more source

Syndecan-1 as a severity biomarker for patients with trauma

Frontiers in Medicine, 2022
Tissue injury and hemorrhage induced by trauma lead to degradation of the endothelial glycocalyx, causing syndecan-1 (SDC-1) to be shed into the blood. In this study, we investigated whether serum SDC-1 is useful for evaluating trauma severity in patients.
Keiko Suzuki, Keiko Suzuki, Hideshi Okada, Kazuyuki Sumi, Hiroyuki Tomita, Ryo Kobayashi, Ryo Kobayashi, Takuma Ishihara, Yosuke Mizuno, Fuminori Yamaji, Ryo Kamidani, Tomotaka Miura, Tomotaka Miura, Ryu Yasuda, Yuichiro Kitagawa, Tetsuya Fukuta, Kodai Suzuki, Takahito Miyake, Norihide Kanda, Tomoaki Doi, Takahiro Yoshida, Shozo Yoshida, Shozo Yoshida, Nobuyuki Tetsuka, Shinji Ogura, Akio Suzuki, Akio Suzuki   +26 more
openaire   +3 more sources

The Role of Syndecan-1 in Malignancies

Annals of Medicine, 1996
Syndecans form a family of cell surface proteoglycans, which can interact with various effector molecules, such as extracellular matrix (ECM) molecules and growth factors. Syndecan-1 is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic ...
Pirjo Inki, Markku Jalkanen
openaire   +3 more sources