Results 31 to 40 of about 24,713 (214)

Association of loss of epithelial syndecan-1 with stage and local metastasis of colorectal adenocarcinomas: An immunohistochemical study of clinically annotated tumors

BMC Cancer, 2008
Background Syndecan-1 is a transmembrane proteoglycan with important roles in cell-cell and cell-extracellular matrix adhesion and as a growth factor co-receptor.
Skacel Marek, Hashimoto Yosuke, Adams Josephine C   +2 more
doaj   +1 more source

Novel genes and pathways modulated by syndecan-1: implications for the proliferation and cell-cycle regulation of malignant mesothelioma cells. [PDF]

PLoS ONE, 2012
Malignant pleural mesothelioma is a highly malignant tumor, originating from mesothelial cells of the serous cavities. In mesothelioma the expression of syndecan-1 correlates to epithelioid morphology and inhibition of growth and migration.
Tünde Szatmári, Filip Mundt, Ghazal Heidari-Hamedani, Fang Zong, Elena Ferolla, Andrey Alexeyenko, Anders Hjerpe, Katalin Dobra   +7 more
doaj   +1 more source

S-maltoheptaose targets syndecan-bound effectors to reduce smoking-related neutrophilic inflammation. [PDF]

, 2015
Cigarette smoke induces injury and neutrophilic inflammation in the airways of smokers. The stability and activity of inflammatory effectors, IL8 and neutrophil elastase (NE), can be prolonged by binding to airway heparan sulfate (HS)/syndecan-1, posing ...
Chan, CH, Freeman, C, Ip, MSM, Lam, CLD, Mak, JCW, Shum, DKY   +5 more
core   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Measuring the Concentration of Serum Syndecan-1 to Assess Vascular Endothelial Glycocalyx Injury During Hemodialysis

Frontiers in Medicine, 2021
Glycocalyx is present on the surface of healthy endothelium, and the concentration of serum syndecan-1 can serve as an injury marker. This study aimed to assess endothelial injury using serum syndecan-1 as a marker of endothelial glycocalyx injury in ...
Keigo Kusuzawa, Keiko Suzuki, Hideshi Okada, Kodai Suzuki, Chihiro Takada, Soichiro Nagaya, Ryu Yasuda, Haruka Okamoto, Takuma Ishihara, Hiroyuki Tomita, Yuki Kawasaki, Toru Minamiyama, Ayane Nishio, Hirotsugu Fukuda, Takuto Shimada, Yuto Tamaoki, Tomoki Yoshida, Yusuke Nakashima, Naokazu Chiba, Genki Yoshimura, Ryo Kamidani, Tomotaka Miura, Tomotaka Miura, Hideaki Oiwa, Hideaki Oiwa, Fuminori Yamaji, Yosuke Mizuno, Takahito Miyake, Yuichiro Kitagawa, Tetsuya Fukuta, Tomoaki Doi, Akio Suzuki, Takahiro Yoshida, Nobuyuki Tetsuka, Shozo Yoshida, Shozo Yoshida, Shinji Ogura   +36 more
doaj   +1 more source

Heparinase selectively sheds heparan sulphate from the endothelial glycocalyx [PDF]

, 2008
A healthy vascular endothelium is coated by the endothelial glycocalyx. Its main constituents are transmembrane syndecans and bound heparan sulphates. This structure maintains the physiological endothelial permeability barrier and prevents leukocyte and ...
Becker, Bernhard F., Chappell, Daniel, Conzen, Peter, Jacob, Matthias, Rehm, Markus, Stoeckelhuber, Mechthild, Welsch, Ulrich   +6 more
core   +1 more source

Biomarker profiles of acute heart failure patients with a mid-range ejection fraction [PDF]

, 2017
OBJECTIVES: In this study, the authors used biomarker profiles to characterize differences between patients with acute heart failure with a midrange ejection fraction (HFmrEF) and compare them with patients with a reduced (heart failure with a ...
Bloomfield, Daniel M, Cleland, John G.F., Cotter, Gad, Davison, Beth, Dittrich, Howard C, Givertz, Michael M, Hillege, Hans L, Khan, Mohsin A F, Mentz, Robert J, Metra, Marco, O'Connor, Christopher M, Ponikowski, Piotr, Teerlink, John R, Tromp, Jasper, van der Meer, Peter, Van Veldhuisen, Dirk J, Voors, Adriaan A.   +16 more
core   +2 more sources

Molecular functions of syndecan-1 in disease [PDF]

Matrix Biology, 2012
Syndecan-1 is a cell surface heparan sulfate proteoglycan that binds to many mediators of disease pathogenesis. Through these molecular interactions, syndecan-1 can modulate leukocyte recruitment, cancer cell proliferation and invasion, angiogenesis, microbial attachment and entry, host defense mechanisms, and matrix remodeling.
Yvonne Hui-Fang, Teng, Rafael S, Aquino, Pyong Woo, Park   +2 more
openaire   +2 more sources

Syndecan-1 in the mouse parietal peritoneum microcirculation in inflammation. [PDF]

PLoS ONE, 2014
BACKGROUND: The heparan sulfate proteoglycan syndecan-1 (CD138) was shown to regulate inflammatory responses by binding chemokines and cytokines and interacting with adhesion molecules, thereby modulating leukocyte trafficking to tissues.
Paulina M Kowalewska, Amanda L Patrick, Alison E Fox-Robichaud   +2 more
doaj   +1 more source

Functional Characterization of Mouse Syndecan-1 Promoter [PDF]

Journal of Biological Chemistry, 1996
The members of the syndecan family are temporally and spatially expressed heparan sulfate proteoglycans of various tissues, where they mediate extracellular influences on cell morphology and behavior. Functional characterization of the mouse syndecan-1 promoter was carried out in order to elucidate the mechanisms involved in the maintenance of the high
T, Vihinen, A, Määttä, P, Jaakkola, P, Auvinen, M, Jalkanen   +4 more
openaire   +2 more sources