Results 41 to 50 of about 24,713 (214)
Frontiers in Oncology, 2013 Proteoglycans and in particular the syndecans are involved in the differentiation process across the epithelial-mesenchymal axis, principally through their ability to bind growth factors and modulate their downstream signalling.
Tünde eSzatmári, Katalin eDobra
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Glycobiology of syndecan-1 in bacterial infections [PDF]
Biochemical Society Transactions, 2018 Syndecan-1 (Sdc1) is a major cell surface heparan sulfate (HS) proteoglycan of epithelial cells, a cell type targeted by many bacterial pathogens early in their pathogenesis. Loss of Sdc1 in mice is a gain-of-function mutation that significantly decreases the susceptibility to several bacterial infections, suggesting that subversion of Sdc1 is an ...
Rafael S, Aquino +2 more
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Antirheumatic treatment is associated with reduced serum Syndecan-1 in Rheumatoid Arthritis.
PLoS ONE, 2021 The endothelial glycocalyx (EG) is essential for proper function of the endothelium and for vascular integrity, but its role in premature atherogenesis in rheumatoid arthritis (RA) has not been studied yet.
Gia Deyab +10 more
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Heparan sulfate proteoglycans undergo differential expression alterations in left sided colorectal cancer, depending on their metastatic character [PDF]
, 2018 Background Heparan sulfate proteoglycans (HSPGs) are complex molecules which play a role in the invasion and growth and metastatic properties of cancerous cells.
Castañón de la Torre, Sonia +6 more
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Distribution of syndecan-1 protein in developing mouse teeth
Frontiers in Physiology, 2015 Syndecan-1 is a cell surface proteoglycan involved in the regulation of various biological processes such as proliferation, migration, condensation and differentiation of cells, intercellular communication and morphogenesis.
Anna eFilatova +2 more
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Endothelial glycocalyx during early reperfusion in patients undergoing cardiac surgery.
PLoS ONE, 2021 BackgroundExperimental cardiac ischemia-reperfusion injury causes degradation of the glycocalyx and coronary washout of its components syndecan-1 and heparan sulfate.
Arie Passov +5 more
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Detection of Syndecan-1 and Heparanase-1 Genes in Esophageal Carcinoma by Quantitative RT-PCR
Cancer Biology & Medicine, 2010 OBJECTIVE To quantitatively explore the expression of Syndecan-1 and heparanase-1 in esophageal cancer tissue as well as their relationship with the clinicopathological factors, in order to evaluate their roles in tumor invasion and metastasis.METHODS
Jun-li SI, Yu-qin QI, Jing-yuan CUI
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Molecular Medicine, 2021 Background We investigated the feasibility of two biomarkers of endothelial damage (Syndecan-1 and thrombomodulin) in coronavirus disease 2019 (COVID-19), and their association with inflammation, coagulopathy, and mortality.
Dong Zhang +11 more
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Syndecan-1 Amplifies Angiotensin II–Induced Cardiac Fibrosis [PDF]
Hypertension, 2010 Syndecan-1 (Synd1) is a transmembrane heparan sulfate proteoglycan that functions as a coreceptor for various growth factors and modulates signal transduction. The present study investigated whether Synd1, by affecting growth factor signaling, may play a role in hypertension-induced cardiac fibrosis and dysfunction.
Schellings, Mark W. M. +9 more
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Journal of Bone Oncology, 2014 Background: Breast cancer often metastasizes into bone and leads to osteolytic lesions. The underlying mechanisms, however, are complex and not fully understood.
Peggy Benad-Mehner +5 more
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