Aberrant Expression of Syndecan-1 in Cervical Cancers [PDF]
Pathology & Oncology Research, 2020 Syndecan-1, is a transmembrane heparan/chondroitin sulfate proteoglycan necessary for cell-cell and cell-matrix interactions. Its decreased level on the cell surface correlates with poor prognosis in several tumor types. Aberrant stromal localization of syndecan-1 is also considered an unfavorable prognostic factor in various human malignancies. In the
Katalin Karászi +7 more
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BMC Infectious Diseases, 2023 Background With the emergence of coronavirus disease of 2019 (COVID-19), several blood biomarkers have been identified, including the endothelial biomarker syndecan-1, a surface proteoglycan.
Elina Ghondaghsaz +5 more
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Frontiers in Cell and Developmental Biology, 2021 Basal-like breast cancer is characterized by an aggressive clinical outcome and presence of metastasis, for which effective therapies are unavailable.
Satomi Nadanaka +2 more
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Specific syndecan-1 domains regulate mesenchymal tumor cell adhesion, motility and migration. [PDF]
PLoS ONE, 2011 BackgroundSyndecans are proteoglycans whose core proteins have a short cytoplasmic domain, a transmembrane domain and a large N-terminal extracellular domain possessing glycosaminoglycan chains. Syndecans are involved in many important cellular processes.
Fang Zong +9 more
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Involvement of heparanase in the pathogenesis of acute kidney injury: Nephroprotective effect of PG545 [PDF]
, 2017 Despite the high prevalence of acute kidney injury (AKI) and its association with increased morbidity and mortality, therapeutic approaches for AKI are disappointing. This is largely attributed to poor understanding of the pathogenesis of AKI. Heparanase,
Abassi, Zaid +16 more
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Syndecan-1 and Its Expanding List of Contacts [PDF]
Advances in Wound Care, 2015 Significance: The binding of cytokines and growth factors to heparan sulfate (HS) chains on proteoglycans generates gradients that control development and regulate wound healing. Syndecan-1 (sdc1) is an integral membrane HS proteoglycan. Its structure allows it to bind with cytosolic, transmembrane, and extracellular matrix (ECM) proteins.
Mary Ann, Stepp +3 more
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Syndecan-1 Promotes Hepatocyte-Like Differentiation of Hepatoma Cells Targeting Ets-1 and AP-1
Biomolecules, 2020 Syndecan-1 is a transmembrane heparan sulfate proteoglycan which is indispensable in the structural and functional integrity of epithelia. Normal hepatocytes display strong cell surface expression of syndecan-1; however, upon malignant transformation ...
Péter Hollósi +10 more
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Frontiers in Pharmacology, 2022 Purpose: We aimed to examine the prognostic value of syndecan-1 as a marker of glycocalyx injury in patients with acute ischemic stroke (AIS) receiving rt-PA intravenous thrombolysis.Methods: The study included 108 patients with AIS treated with rt-PA ...
Fangfang Zhao +20 more
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A syndecan és decorin proteoglikánok kóroki szerepének modellezése májbetegségekben = Experimental models to study the significance of syndecan-1 and decorin in the development of liver diseases [PDF]
, 2007 Az elmúlt 4 évben olyan modellrendszereket dolgoztunk ki, melyekben a proteoglikánok kifejeződését megváltoztattuk. Kialakitottunk egy decorin -/- TGF béta-1 +/- kettős transzgén egértörzset, melyen a cirrhosis és a hepatokarcinogenezis eseményeit ...
Kovalszky, Ilona +2 more
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Fibroblast growth factor-2 (FGF2) and syndecan-1 (SDC1) are potential biomarkers for putative circulating CD15+/CD30+ cells in poor outcome Hodgkin lymphoma patients. [PDF]
, 2013 BACKGROUND: High risk, unfavorable classical Hodgkin lymphoma (cHL) includes those patients with primary refractory or early relapse, and progressive disease.
Bhattacharyya, Pritish +12 more
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