Results 81 to 90 of about 9,706,454 (336)

Chemoenzymatic synthesis

Communications Chemistry
Communications Chemistry is pleased to introduce a Collection of research works focused on recent developments within the interdisciplinary field of chemoenzymatic synthesis. Here, the Guest Editors highlight key themes and look towards the future of this research field.
Borowiecki, Paweł, Schmidt, Sandy
openaire   +3 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Cellophane-Based Membranes for Purification of Aqueous Media from Various Pollutants

Учёные записки Казанского университета: Серия Естественные науки
The process of nanofiltration purification of water from various organic pollutants was examined. Cellophane film made from cheap natural raw materials was used as a membrane.
A. A. Yushkin, A. P. Nebesskaya, E. A. Grushevenko, A. O. Malakhov, T. S. Anokhina, A. V. Volkov   +5 more
doaj   +1 more source

Palladium-catalysed formation of vicinal all-carbon quaternary centres via propargylation

Nature Communications, 2016
Formation of vicinal, quaternary stereocentres is challenging, but such products are commonly encountered in nature. Here, the authors report a palladium catalysed process to form vicinal quaternary carbons via propargylation, including in enantiopure ...
Xin Huang, Shangze Wu, Wangteng Wu, Pengbin Li, Chunling Fu, Shengming Ma   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

ℋ∞ optimization with spatial constraints [PDF]

, 1995
A generalized ℋ∞ synthesis problem where non-euclidian spatial norms on the disturbances and output error are used is posed and solved. The solution takes the form of a linear matrix inequality. Some problems which fall into this class are presented.
D'Andrea, Raffaello
core  

Reduced spectral synthesis and compact operator synthesis

, 2019
We introduce and study the notion of reduced spectral synthesis, which unifies the concepts of spectral synthesis and uniqueness in locally compact groups.
Shulman, V. S., Todorov, I. G., Turowska, L.   +2 more
core   +1 more source