Results 21 to 30 of about 7,779 (204)
mBio, 2021 There is growing evidence that coronavirus disease 2019 (COVID-19) affects males more severely than females, including compelling evidence indicating that biological sex is an important clinical factor influencing disease pathology and outcomes. In their
Rafael Tomoya Michita +1 more
doaj +1 more source
Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2
Nature Communications, 2021 Until today effective antivirals for COVID-19 treatment are not widely available. Here, Zhao et al. characterize a dual-functional cross-linking peptide, 8P9R, that can inhibit SARS-CoV-2 virus entry in vitro and suppresses viral replication in vivo in ...
Hanjun Zhao +15 more
doaj +1 more source
Nature Communications, 2022 Since the emergence of SARS-CoV-2 several variants of concerns have been identified, with altered disease progression and transmission dynamics. Here, Armando et al.
Federico Armando +14 more
doaj +1 more source
Generation of transgenic golden Syrian hamsters [PDF]
Cell Research, 2014 Golden Syrian hamsters are small rodents, but they display many features that resemble the physiology and metabolism of humans. Hamsters have been widely used in many research areas, including carcinogenesis1, reproduction2, virology3, diabetes4 and cardiovascular diseases5.
Gao, Mingming +12 more
openaire +2 more sources
Frontiers in Cardiovascular Medicine, 2022 RationaleApoC3 plays a central role in the hydrolysis process of triglyceride (TG)-rich lipoproteins mediated by lipoprotein lipase (LPL), which levels are positively associated with the incidence of cardiovascular disease (CVD). Although targeting ApoC3
Yitong Xu +13 more
doaj +1 more source
Nature Communications, 2021 Here, the authors combine structural, binding, mutational in vitro and in vivo assays to characterize neutralizing antibodies derived from IGHV3-53/3-66 against SARS-CoV-2, finding one antibody, named P5A-3C8, to exhibit protective efficacy in a golden ...
Qi Zhang +28 more
doaj +1 more source
Validation of Stable Housekeeping Genes for Quantitative Real Time PCR in Golden Syrian Hamster [PDF]
, 2021 Background: Golden Syrian hamster (GSH) have many advantages as animal models in preclinical research, but their application is currently limited by the lack of standardized techniques for analyzing gene expression.
Peng, Ying +8 more
core +1 more source
Transmission of chronic wasting disease identifies a prion strain causing cachexia and heart infection in hamsters. [PDF]
PLoS ONE, 2011 Chronic wasting disease (CWD) is an emerging prion disease of free-ranging and captive cervids in North America. In this study we established a rodent model for CWD in Syrian golden hamsters that resemble key features of the disease in cervids including ...
Richard A Bessen +7 more
doaj +1 more source
Analysis of Arbidol® Effectiveness agains an Experimental Form of Severe Acute Respiratory Syndrome
Антибиотики и Химиотерапия, 2020 Studies have been conducted to assess the effectiveness of Arbidol® in relation to the experimental form of severe acute respiratory syndrome in Syrian Golden hamster.
S. Ya. Loginova +5 more
doaj +1 more source
Effects of ultra-purified polymerized bovine hemoglobin on local tissue oxygen tension in striated skin muscle - An efficacy study in the hamster [PDF]
, 2002 The development of hemoglobin-based oxygen carriers has been propagated for replacement of the oxygen carrying properties of red blood cells for almost one century.
Nolte, Dirk +2 more
core +1 more source