Results 21 to 30 of about 328,019 (200)

Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2

Nature Communications, 2021
Until today effective antivirals for COVID-19 treatment are not widely available. Here, Zhao et al. characterize a dual-functional cross-linking peptide, 8P9R, that can inhibit SARS-CoV-2 virus entry in vitro and suppresses viral replication in vivo in ...
Hanjun Zhao, Kelvin K. W. To, Hoiyan Lam, Xinxin Zhou, Jasper Fuk-Woo Chan, Zheng Peng, Andrew C. Y. Lee, Jianpiao Cai, Wan-Mui Chan, Jonathan Daniel Ip, Chris Chung-Sing Chan, Man Lung Yeung, Anna Jinxia Zhang, Allen Wing Ho Chu, Shibo Jiang, Kwok-Yung Yuen   +15 more
doaj   +1 more source

Therapeutic Efficacy of Indole-3-Carbinol Against SARS-CoV-2-Induced Acute Respiratory Distress Syndrome: A Dual Antiviral and Anti-Inflammatory Approach in a Golden Syrian Hamster Model. [PDF]

J Cell Mol Med
ABSTRACT SARS‐CoV‐2 has caused a global pandemic, resulting in over two million deaths and creating an urgent need for effective treatments. Severe COVID‐19 is frequently complicated by respiratory failure and acute respiratory distress syndrome (ARDS), the primary drivers of mortality.
Federica C, Barbara R, Andrea L, Michela B, Marco P, Francesca S, Manuel S, Alessandro M, Palyi B, Deri D, Novak B, Kis Z, Filippone C, Pandolfi PP, Giuseppe N.   +14 more
europepmc   +2 more sources

SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamsters

Nature Communications, 2022
Since the emergence of SARS-CoV-2 several variants of concerns have been identified, with altered disease progression and transmission dynamics. Here, Armando et al.
Federico Armando, Georg Beythien, Franziska K. Kaiser, Lisa Allnoch, Laura Heydemann, Malgorzata Rosiak, Svenja Becker, Mariana Gonzalez-Hernandez, Mart M. Lamers, Bart L. Haagmans, Kate Guilfoyle, Geert van Amerongen, Malgorzata Ciurkiewicz, Albert D.M.E. Osterhaus, Wolfgang Baumgärtner   +14 more
doaj   +1 more source

Models of Oral Epithelial Dysplasia: A Systematic Review and Temporal Analysis. [PDF]

J Oral Pathol Med
ABSTRACT Background Oral squamous cell carcinoma (OSCC) is the most common malignancy of the head and neck, associated with substantial morbidity and mortality worldwide. Oral epithelial dysplasia (OED) can precede OSCC, offering a critical window for preventive and therapeutic intervention.
Ngokwe ZB, Wicaksono S, McCullough M, Celentano A, Yap T.   +4 more
europepmc   +2 more sources

Generation of transgenic golden Syrian hamsters [PDF]

Cell Research, 2014
Golden Syrian hamsters are small rodents, but they display many features that resemble the physiology and metabolism of humans. Hamsters have been widely used in many research areas, including carcinogenesis1, reproduction2, virology3, diabetes4 and cardiovascular diseases5.
Gao, Mingming, Zhang, Baoyu, Liu, Jinjiao, Guo, Xin, Li, Haibo, Wang, Tao, Zhang, Zifu, Liao, Jiawei, Cong, Nathan, Wang, Yuhui, Yu, Liqing, Zhao, Dong, Liu, George   +12 more
openaire   +2 more sources

Targeting ApoC3 Paradoxically Aggravates Atherosclerosis in Hamsters With Severe Refractory Hypercholesterolemia

Frontiers in Cardiovascular Medicine, 2022
RationaleApoC3 plays a central role in the hydrolysis process of triglyceride (TG)-rich lipoproteins mediated by lipoprotein lipase (LPL), which levels are positively associated with the incidence of cardiovascular disease (CVD). Although targeting ApoC3
Yitong Xu, Jiabao Guo, Ling Zhang, Guolin Miao, Pingping Lai, Wenxi Zhang, Lili Liu, Xinlin Hou, Yuhui Wang, Wei Huang, George Liu, Mingming Gao, Xunde Xian, Xunde Xian   +13 more
doaj   +1 more source

Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2

Nature Communications, 2021
Here, the authors combine structural, binding, mutational in vitro and in vivo assays to characterize neutralizing antibodies derived from IGHV3-53/3-66 against SARS-CoV-2, finding one antibody, named P5A-3C8, to exhibit protective efficacy in a golden ...
Qi Zhang, Bin Ju, Jiwan Ge, Jasper Fuk-Woo Chan, Lin Cheng, Ruoke Wang, Weijin Huang, Mengqi Fang, Peng Chen, Bing Zhou, Shuo Song, Sisi Shan, Baohua Yan, Senyan Zhang, Xiangyang Ge, Jiazhen Yu, Juanjuan Zhao, Haiyan Wang, Li Liu, Qining Lv, Lili Fu, Xuanling Shi, Kwok Yung Yuen, Lei Liu, Youchun Wang, Zhiwei Chen, Linqi Zhang, Xinquan Wang, Zheng Zhang   +28 more
doaj   +1 more source

Transmission of chronic wasting disease identifies a prion strain causing cachexia and heart infection in hamsters. [PDF]

PLoS ONE, 2011
Chronic wasting disease (CWD) is an emerging prion disease of free-ranging and captive cervids in North America. In this study we established a rodent model for CWD in Syrian golden hamsters that resemble key features of the disease in cervids including ...
Richard A Bessen, Cameron J Robinson, Davis M Seelig, Christopher P Watschke, Diana Lowe, Harold Shearin, Scott Martinka, Alex M Babcock   +7 more
doaj   +1 more source

Analysis of Arbidol® Effectiveness agains an Experimental Form of Severe Acute Respiratory Syndrome

Антибиотики и Химиотерапия, 2020
Studies have been conducted to assess the effectiveness of Arbidol® in relation to the experimental form of severe acute respiratory syndrome in Syrian Golden hamster.
S. Ya. Loginova, V. N. Shchukina, S. V. Borisevich, R. A. Khamitov, V. A. Maksimov, A. M. Shuster   +5 more
doaj   +1 more source

Characterizations of Hamster Retina as a Model for Studies of Retinal Cholesterol Homeostasis

Biology, 2021
Cholesterol homeostasis in the retina, a sensory organ in the back of the eye, has been studied in mice but not hamsters, despite the latter being more similar to humans than mice with respect to their whole-body cholesterol maintenance. The goal of this
Nicole El-Darzi, Natalia Mast, Brian Dailey, John Denker, Yong Li, Joseph Vance, Irina A. Pikuleva   +6 more
doaj   +1 more source