Results 81 to 90 of about 7,779 (204)

In vivo inhibition of nuclear ACE2 translocation protects against SARS-CoV-2 replication and lung damage through epigenetic imprinting

Nature Communications, 2023
In vitro, ACE2 translocates to the nucleus to induce SARS-CoV-2 replication. Here, using digital spatial profiling of lung tissues from SARS-CoV-2-infected golden Syrian hamsters, we show that a specific and selective peptide inhibitor of nuclear ACE2 ...
Wen Juan Tu, Michelle Melino, Jenny Dunn, Robert D. McCuaig, Helle Bielefeldt-Ohmann, Sofiya Tsimbalyuk, Jade K. Forwood, Taniya Ahuja, John Vandermeide, Xiao Tan, Minh Tran, Quan Nguyen, Liang Zhang, Andy Nam, Liuliu Pan, Yan Liang, Corey Smith, Katie Lineburg, Tam H. Nguyen, Julian D. J. Sng, Zhen Wei Marcus Tong, Keng Yih Chew, Kirsty R. Short, Roger Le Grand, Nabila Seddiki, Sudha Rao   +25 more
doaj   +1 more source

Ovarian and Other Timor Induction by 7,12-Dimethylbenz(a)Anthracene in the Syrian Golden Hamster [PDF]

, 1971
Two or three weekly repeated intravenous injections of 7,12-dimethylbenz(a)-anthracene (DMBA) in 15% fat emulsion were given to adult randomly bred Syrian golden hamsters.
Bela Toth
core   +1 more source

Glanders: Past, Present and Future of a Neglected Zoonosis as a Threat in Veterinary and Human Health

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
This review displays a comprehensive overview of glanders, including aetiology, epidemiology, pathogenesis, diagnosis, control strategies and ongoing eradication programs. It has also reviewed differential diagnosis and treatment both in animals and humans as well as organism's antimicrobial properties.
Yahya Kanani, Ahmad Oryan, Abdollah Derakhshandeh   +2 more
wiley   +1 more source

FNDC4 and FNDC5 Attenuate SARS‐CoV‐2 S1‐Induced Inflammatory Responses in Human Adipose Tissue

European Journal of Clinical Investigation, Volume 56, Issue 5, May 2026.
In obesity, reduced FNDC4 and FNDC5 amplify SARS‐CoV‐2 S1–driven inflammation in visceral adipose tissue. These adipo‐myokines limit adipocyte–macrophage inflammatory signalling, suggesting a protective role against viral‐induced adipose tissue dysfunction.
Gabriela Neira, Julia Hernández‐Castañeda, Victoria Catalán, Sara Becerril, Marina Martín, Víctor Valentí, Rafael Moncada, Camilo Silva, Javier Gómez‐Ambrosi, Javier Escalada, Gema Frühbeck, Amaia Rodríguez   +11 more
wiley   +1 more source

Pathogenic and transcriptomic differences of emerging SARS-CoV-2 variants in the Syrian golden hamster model [PDF]

EBioMedicine, 2021
O’Donnell KL, Pinski AN, Clancy CS, Gourdine T, Shifflett K, Fletcher P, Messaoudi I, Marzi A.   +7 more
europepmc   +2 more sources

Early Surge in Brain GFAP Distribution in Female Hamsters With Mild Peripheral COVID‐19

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Mild to moderate coronavirus disease 2019 (COVID‐19) is primarily associated with respiratory symptoms, yet a range of neurological effects are experienced by a large proportion of affected individuals. Why this occurs is not fully understood. Using a hamster model of mild to moderate COVID‐19, which mimics key aspects of the majority of human COVID‐19
Mohammadreza Rahmani Manesh, Leigh E. Wicki‐Stordeur, Nicole S. York, Robert Vendramelli, Bryce Warner, Haley A. Vecchiarelli, Luke Rainier‐Pope, Mohammadparsa Khakpour, Connor A. Larkey, Lucas R. Bennouna, Marie‐Ève Tremblay, Darwyn Kobasa, Leigh Anne Swayne   +12 more
wiley   +1 more source

Comparative virology and pathology of Monkeypox virus in Syrian hamsters, C57BL/6, and BALB/c mice: A framework for preclinical model selection

Animal Models and Experimental Medicine, Volume 9, Issue 4, Page 829-837, April 2026.
This study compared monkeypox virus (MPXV) infection in three small animal models: Syrian hamsters, C57BL/6 mice, and BALB/c mice. Following intraperitoneal inoculation, Syrian hamsters exhibited the highest susceptibility, with rapid systemic viral dissemination, elevated splenic and renal viral burdens, and severe histopathological damage, followed ...
Xiaohui Wei, Jing Wu, Hekai Yang, Na Li, Binbin Zhao, Wanjun Peng, Na Rong, Wei Zhang, Jing Xue, Jiangning Liu   +9 more
wiley   +1 more source

LDL Receptor Gene-ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia With Dominant Inheritance and Diet-induced Coronary Atherosclerosis

EBioMedicine, 2018
Familial hypercholesterolemia (FH) is an autosomal dominant genetic disease caused mainly by LDL receptor (Ldlr) gene mutations. Unlike FH patients, heterozygous Ldlr knockout (KO) mice do not show a dominant FH trait.
Xin Guo, Mingming Gao, Yunan Wang, Xiao Lin, Liu Yang, Nathan Cong, Xiangbo An, Feng Wang, Kai Qu, Liqing Yu, Yuhui Wang, Jinjie Wang, Haibo Zhu, Xunde Xian, George Liu   +14 more
doaj   +1 more source

Armenian hamster female protein: a pentraxin under complex regulation [PDF]

, 1990
The serum of Armenian hamster (Cricetulus migratorius) contains a protein homologous to female protein (FP) that has been characterized in the Syrian (golden) hamster. Of unknown function, FP belongs to a family of proteins (called pentraxins) that have
M. J. Ross, J. E. Coe
core   +1 more source

Genomic Mutations in SARS-CoV-2 Genome following Infection in Syrian Golden Hamster and Associated Lung Pathologies. [PDF]

Pathogens, 2023
Rudramurthy GR, Naveenkumar CN, Bharathkumar K, Shandil RK, Narayanan S.   +4 more
europepmc   +1 more source