Results 111 to 120 of about 811,099 (302)

Designing tailored maintenance strategies for systematic reviews and clinical practice guidelines using the Portfolio Maintenance by Test-Treatment (POMBYTT) framework

BMC Medical Research Methodology
Background Organizations face diverse contexts and requirements when updating and maintaining their portfolio, or pool, of systematic reviews or clinical practice guidelines they need to manage.
Michiel S. Oerbekke, Roy G. Elbers, Maarten J. van der Laan, Lotty Hooft   +3 more
doaj   +1 more source

Risk of postoperative pulmonary complications in adult surgical patients with metabolic syndrome: a systematic review and meta-analysis protocol [PDF]

, 2019
Background: Metabolic syndrome (MetS) is defined as an accumulation of risk factors that include chronic hypertension, dyslipidaemia, insulin resistance and obesity and leads to an increased risk for diabetes, cardiovascular disease and stroke.
Gow, Jeffrey, Norris, Philip, Ralph, Nicholas, Silvey, Natalie, Viljoen, Bianca   +4 more
core   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Green BPM as a business-oriented discipline : a systematic mapping study and research agenda [PDF]

, 2019
Green Business Process Management (BPM) focuses on the ecological impact of business processes. This article provides a systematic mapping study of Green BPM literature to evaluate five attributes of the Green BPM research area: (1) scope, (2 ...
Couckuyt, Dries, Van Looy, Amy
core   +1 more source

A systematic review of physical and rehabilitation medicine topics as developed by the Cochrane Collaboration.

Europa medicophysica, 2007
The aim of this paper is to give an overview of the Cochrane Collaboration, its development over the years, and its usefulness for physical and rehabilitation medicine specialists. After introducing the Cochrane Collaboration, we systematically analyzed all titles of the reviews in each of the 50 review groups.
NEGRINI, Stefano, S. Minozzi, M. Taricco, V. Ziliani, F. Zaina   +4 more
openaire   +3 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Honey as Topical Dressing in Chronic Wound: A Systematic Review

International Journal of Science and Research (IJSR), 2021
Komang Abdi Baskara Mayun, Ida Yustiana, IB Pramana Suaryasa, I Made Adipta Adiputra   +3 more
openaire   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Topical insulin as a novel treatment for persistent epithelial defects and other ocular surface disorders: a systematic review

Graefe's Archive for Clinical and Experimental Ophthalmology
Through this systematic review, we evaluated the therapeutic potential of topical eye insulin in different concentrations to treat several surface ocular pathologies, including: persistent epithelial defects, diabetic keratopathy after a vitrectomy, neutrophic keratopathy and dry eye syndrome.
Raluca Bievel Radulescu, Stefano Ferrari, Horia T. Stanca, Diego Ponzin   +3 more
openaire   +3 more sources

Systematic reviews and cancer research: a suggested stepwise approach

BMC Cancer, 2018
Systematic reviews, with or without meta-analysis, play an important role today in synthesizing cancer research and are frequently used to guide decision-making.
George A. Kelley, Kristi S. Kelley
doaj   +1 more source