Proteomics for systems toxicology [PDF]
Computational and Structural Biotechnology Journal, 2014 Current toxicology studies frequently lack measurements at molecular resolution to enable a more mechanism-based and predictive toxicological assessment.
Bjoern Titz +7 more
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Metabolomics- and systems toxicology-based hepatotoxicity mechanism of Sophorae Tonkinensis Radix et Rhizoma in rats [PDF]
Frontiers in Pharmacology, 2022 Drug-induced liver injury (DILI) is a major challenge to the development and clinical application of drugs, especially limits the global application of Chinese herbal medicines, because the material basis and mechanisms of some Chinese herbal medicines ...
Dengxiang Yu +5 more
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Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish [PDF]
Frontiers in Genetics, 2021 Adverse outcomes that result from chemical toxicity are rarely caused by dysregulation of individual proteins; rather, they are often caused by system-level perturbations in networks of molecular events. To fully understand the mechanisms of toxicity, it
Roman A. Li +9 more
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Parkinson’s Disease and the Metal–Microbiome–Gut–Brain Axis: A Systems Toxicology Approach [PDF]
Antioxidants, 2021 Parkinson’s Disease (PD) is a neurodegenerative disease, leading to motor and non-motor complications. Autonomic alterations, including gastrointestinal symptoms, precede motor defects and act as early warning signs.
Lady Johanna Forero-Rodríguez +4 more
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Casting a wide net: use of diverse model organisms to advance toxicology [PDF]
Disease Models & Mechanisms, 2020 Toxicology – the study of how chemicals interact with biological systems – has clear relevance to human health and disease. Persistent exposure to natural and synthetic chemicals is an unavoidable part of living on our planet; yet, we understand very ...
Mark E. Hahn, Kirsten C. Sadler
doaj +3 more sources
Systems Toxicology: Real World Applications and Opportunities. [PDF]
Chem Res Toxicol, 2017 Systems Toxicology aims to change the basis of how adverse biological effects of xenobiotics are characterized from empirical end points to describing modes of action as adverse outcome pathways and perturbed networks. Toward this aim, Systems Toxicology
Hartung T +8 more
europepmc +4 more sources
Systems Toxicology Approach to Identifying Paracetamol Overdose. [PDF]
CPT Pharmacometrics Syst Pharmacol, 2018 Paracetamol (acetaminophen (APAP)) is one of the most commonly used analgesics in the United Kingdom and the United States. However, exceeding the maximum recommended dose can cause serious liver injury and even death.
Mason CL +5 more
europepmc +6 more sources
Functional toxicology: tools to advance the future of toxicity testing [PDF]
Frontiers in Genetics, 2014 The increased presence of chemical contaminants in the environment is an undeniable concern to human health and ecosystems. Historically, by relying heavily upon costly and laborious animal-based toxicity assays, the field of toxicology has often ...
Brandon David Gaytán, Chris eVulpe
doaj +3 more sources
Deciphering Adverse Outcome Pathway Network Linked to Bisphenol F Using Text Mining and Systems Toxicology Approaches. [PDF]
Toxicol Sci, 2020 Rugard M +4 more
europepmc +3 more sources
Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke [PDF]
Computational and Structural Biotechnology Journal, 2020 Cigarette smoke (CS) causes adverse health effects and, for smoker who do not quit, modified risk tobacco products (MRTPs) can be an alternative to reduce the risk of developing smoking-related diseases.
Bjoern Titz +22 more
doaj +2 more sources