Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish [PDF]
Frontiers in Genetics, 2021 Adverse outcomes that result from chemical toxicity are rarely caused by dysregulation of individual proteins; rather, they are often caused by system-level perturbations in networks of molecular events. To fully understand the mechanisms of toxicity, it
Roman A. Li +9 more
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Parkinson’s Disease and the Metal–Microbiome–Gut–Brain Axis: A Systems Toxicology Approach [PDF]
Antioxidants, 2021 Parkinson’s Disease (PD) is a neurodegenerative disease, leading to motor and non-motor complications. Autonomic alterations, including gastrointestinal symptoms, precede motor defects and act as early warning signs.
Lady Johanna Forero-Rodríguez +4 more
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Systems Toxicology: Real World Applications and Opportunities. [PDF]
Chem Res Toxicol, 2017 Systems Toxicology aims to change the basis of how adverse biological effects of xenobiotics are characterized from empirical end points to describing modes of action as adverse outcome pathways and perturbed networks. Toward this aim, Systems Toxicology
Hartung T +8 more
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Systems Toxicology Approach to Identifying Paracetamol Overdose. [PDF]
CPT Pharmacometrics Syst Pharmacol, 2018 Paracetamol (acetaminophen (APAP)) is one of the most commonly used analgesics in the United Kingdom and the United States. However, exceeding the maximum recommended dose can cause serious liver injury and even death.
Mason CL +5 more
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Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity. [PDF]
Toxicol Sci, 2018 CKA, a chemokine receptor antagonist intended for treating inflammatory conditions, produced dose-dependent hepatotoxicity in rats but advanced into the clinic where single doses of CKA up to 600 mg appeared safe in humans. Because existing toxicological
Battista C +6 more
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Proteomics for systems toxicology [PDF]
Computational and Structural Biotechnology Journal, 2014 Current toxicology studies frequently lack measurements at molecular resolution to enable a more mechanism-based and predictive toxicological assessment.
Bjoern Titz +7 more
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The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury. [PDF]
Int J Mol Sci, 2023 Biologics address a range of unmet clinical needs, but the occurrence of biologics-induced liver injury remains a major challenge. Development of cimaglermin alfa (GGF2) was terminated due to transient elevations in serum aminotransferases and total ...
Beaudoin JJ +14 more
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Quantitative Systems Toxicology Modeling Predicts that Reduced Biliary Efflux Contributes to Tolvaptan Hepatotoxicity. [PDF]
Clin Pharmacol Ther, 2021 Patients with autosomal dominant polycystic kidney disease (ADPKD) exhibit enhanced susceptibility to tolvaptan hepatotoxicity relative to other patient populations.
Beaudoin JJ +3 more
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Metabolomics- and systems toxicology-based hepatotoxicity mechanism of Sophorae Tonkinensis Radix et Rhizoma in rats [PDF]
Frontiers in Pharmacology, 2022 Drug-induced liver injury (DILI) is a major challenge to the development and clinical application of drugs, especially limits the global application of Chinese herbal medicines, because the material basis and mechanisms of some Chinese herbal medicines ...
Dengxiang Yu +5 more
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Casting a wide net: use of diverse model organisms to advance toxicology [PDF]
Disease Models & Mechanisms, 2020 Toxicology – the study of how chemicals interact with biological systems – has clear relevance to human health and disease. Persistent exposure to natural and synthetic chemicals is an unavoidable part of living on our planet; yet, we understand very ...
Mark E. Hahn, Kirsten C. Sadler
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