Systems bioengineering approaches for developmental toxicology
Computational and Structural Biotechnology Journal, 2023 Developmental toxicology is the field of study that examines the effects of chemical and physical agents on developing organisms. By using principles of systems biology and bioengineering, a systems bioengineering approach could be applied to study the ...
Beatriz Xavier Soares +2 more
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In Vitro Toxicology Systems [PDF]
, 2013 There has been a dramatic increase in the development and use of in vitro systems in all types of biological disciplines but particularly in pharmacology and toxicology.
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Building medical toxicology capacity in Africa: a review and strategic perspective on the need for fellowship training programs [PDF]
International Journal of Emergency MedicineIntroduction Toxic exposures and poisoning constitute a substantial but underestimated public health hazard throughout Africa, for which pesticides, drugs, traditional medicine, snake venom, and industrial chemicals are a disproportionate cause of ...
Belayneh Dessie Kassa
doaj +2 more sources
Quantitative systems toxicology. [PDF]
Curr Opin Toxicol, 2017 The overarching goal of modern drug development is to optimize therapeutic benefits while minimizing adverse effects. However, inadequate efficacy and safety concerns remain to be the major causes of drug attrition in clinical development. For the past 80 years, toxicity testing has consisted of evaluating the adverse effects of drugs in animals to ...
Bloomingdale P +6 more
europepmc +3 more sources
Quantitative Systems Toxicology Modeling of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended-Release and Immediate-Release Formulations in Adults With Chronic Alcohol Use or Low Glutathione. [PDF]
CPT Pharmacometrics Syst PharmacolYang K +8 more
europepmc +3 more sources
A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure. [PDF]
Ann Glob Health, 2016 Laine JE, Fry RC.
europepmc +2 more sources
Quantitative systems toxicology modeling in pharmaceutical research and development: An industry-wide survey and selected case study examples. [PDF]
CPT Pharmacometrics Syst PharmacolBeattie KA +11 more
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Quantitative Systems Toxicology Predicts Ivacaftor-Induced Oxidative Stress Contributes to CFTR Modulator Hepatotoxicity. [PDF]
Clin Pharmacol TherShi A, Cornwell C, Yang K, Beringer PM.
europepmc +3 more sources
Systems Toxicology: The Future of Risk Assessment. [PDF]
Int J Toxicol, 2015 Risk assessment, in the context of public health, is the process of quantifying the probability of a harmful effect to individuals or populations from human activities. With increasing public health concern regarding the potential risks associated with chemical exposure, there is a need for more predictive and accurate approaches to risk assessment ...
Sauer JM +5 more
europepmc +5 more sources