Comparison of the Hepatotoxic Potential of Two Treatments for Autosomal-Dominant Polycystic Kidney DiseaseUsing Quantitative Systems Toxicology Modeling. [PDF]
Pharm Res, 2020 Autosomal-dominant polycystic kidney disease (ADPKD) is an orphan disease with few current treatment options. The vasopressin V2 receptor antagonist tolvaptan is approved in multiple countries for the treatment of ADPKD, however its use is associated ...
Woodhead JL +3 more
europepmc +2 more sources
Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice. [PDF]
Toxicol Sci, 2020 Smoking cessation is the most effective measure for reducing the risk of smoking-related diseases. However, switching to less harmful products (modified-risk tobacco products [MRTP]) can be an alternative to help reduce the risk for adult smokers who ...
Titz B +16 more
europepmc +2 more sources
Systems Toxicology: The Future of Risk Assessment. [PDF]
Int J Toxicol, 2015 Sauer JM +5 more
europepmc +4 more sources
Deciphering Adverse Outcome Pathway Network Linked to Bisphenol F Using Text Mining and Systems Toxicology Approaches. [PDF]
Toxicol Sci, 2020 Bisphenol F (BPF) is one of several Bisphenol A (BPA) substituents that is increasingly used in manufacturing industry leading to detectable human exposure.
Rugard M +4 more
europepmc +2 more sources
Functional toxicology: tools to advance the future of toxicity testing [PDF]
Frontiers in Genetics, 2014 The increased presence of chemical contaminants in the environment is an undeniable concern to human health and ecosystems. Historically, by relying heavily upon costly and laborious animal-based toxicity assays, the field of toxicology has often ...
Brandon David Gaytán, Chris eVulpe
doaj +3 more sources
Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling. [PDF]
Pharm Res, 2019 Macrolide antibiotics are commonly prescribed treatments for drug-resistant bacterial infections; however, many macrolides have been shown to cause liver enzyme elevations and one macrolide, telithromycin, has been pulled from the market by its provider ...
Woodhead JL +7 more
europepmc +2 more sources
A framework for in vitro systems toxicology assessment of e-liquids. [PDF]
Toxicol Mech Methods, 2016 Various electronic nicotine delivery systems (ENDS), of which electronic cigarettes (e-cigs) are the most recognized prototype, have been quickly gaining ground on conventional cigarettes because they are perceived as less harmful. Research assessing the
Iskandar AR +15 more
europepmc +2 more sources
Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury. [PDF]
Toxicol Sci, 2019 TAK-875 (fasiglifam), a GPR40 agonist in development for the treatment of type 2 diabetes (T2D), was voluntarily terminated in Phase III trials due to adverse liver effects. The potential mechanisms of TAK-875 toxicity were explored by combining in vitro
Longo DM +10 more
europepmc +2 more sources
A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment. [PDF]
Intern Emerg Med, 2019 In the context of tobacco harm-reduction strategy, the potential reduced impact of electronic cigarette (EC) exposure should be evaluated relative to the impact of cigarette smoke exposure.
Iskandar AR +18 more
europepmc +2 more sources
Insights into the molecular mechanisms of Polygonum multiflorum Thunb-induced liver injury: a computational systems toxicology approach. [PDF]
Acta Pharmacol Sin, 2017 An increasing number of cases of herb-induced liver injury (HILI) have been reported, presenting new clinical challenges. In this study, taking Polygonum multiflorum Thunb (PmT) as an example, we proposed a computational systems toxicology approach to ...
Wang YY +9 more
europepmc +2 more sources