Results 31 to 40 of about 323,783 (333)

Role of Tunable Gold Nanostructures in Cancer Nanotheranostics: Implications on Synthesis, Toxicity, Clinical Applications and Their Associated Opportunities and Challenges

Journal of Nanotheranostics, 2023
The existing diagnosis and treatment modalities have major limitations related to their precision and capability to understand several stages of disease development.
Akash Kumar, Nabojit Das, Raja Gopal Rayavarapu   +2 more
doaj   +1 more source

Smart Platinum Nanostructures: A Journey from Synthesis to Advanced Theranostic Applications

Journal of Nanotheranostics, 2023
A significant paradigm shift has been observed in the past decade in the area of theranostics owing to the development of various isotropic and anisotropic metal nanostructures, simultaneous with improved imaging modalities. Platinum-based nanostructures
Akash Kumar, Nabojit Das, Raja Gopal Rayavarapu   +2 more
doaj   +1 more source

Systems biology tools for toxicology [PDF]

Archives of Toxicology, 2012
An important goal of toxicology is to understand and predict the adverse effects of drugs and other xenobiotics. For pharmaceuticals, such effects often emerge unexpectedly in man even when absent from trials in vitro and in animals. Although drugs and xenobiotics act on molecules, it is their perturbation of intracellular networks that matters.
Geenen S, Taylor PN, Snoep JL, Wilson ID, Kenna JG, Westerhoff HV   +5 more
openaire   +5 more sources

Characterization of the interferences of systemic azole antifungal drugs with adrenal steroid biosynthesis using H295R cells and enzyme activity assays

Current Research in Toxicology, 2023
Azole antifungals, designed to inhibit fungal CYP51, have a liability to inhibit human CYP enzymes. Whilst drug-metabolizing CYPs are covered in preclinical safety assessment, those metabolizing endogenous bioactive molecules are usually not ...
Marie-Christin Jäger, Friedrich L. Joos, Denise V. Winter, Alex Odermatt   +3 more
doaj   +1 more source

Insect in vitro System for Toxicology Studies — Current and Future Perspectives

Frontiers in Toxicology, 2021
In vitro cell culture practices are valuable techniques to understand the mechanisms behind vital in vivo biological processes. In vitro cells have helped us to attain a deeper understanding of functions and mechanisms conserved in the course of ...
Sheeja Cc, Damodaran Arun, Lekha Divya
doaj   +1 more source

In silico biomarker analysis of the adverse effects of perfluorooctane sulfonate (PFOS) exposure on the metabolic physiology of embryo-larval zebrafish

Frontiers in Systems Biology
Perfluorooctane sulfonate (PFOS) is a ubiquitous pollutant in global aquatic ecosystems with increasing concern for its toxicity to aquatic wildlife through inadvertent exposures.
Rayna M. Nolen, Lene H. Petersen, Karl Kaiser, Karl Kaiser, Antonietta Quigg, Antonietta Quigg, Antonietta Quigg, David Hala   +7 more
doaj   +1 more source

Identification of environmental etiologies of neurodevelopmental disorders in children

生物医学转化
Neurodevelopmental disorders (NDDs) are a group of chronic developmental brain dysfunctions caused by various genetic or acquired factors, characterized by high disability rates and a lack of effective treatments.
Li Yuanyuan
doaj   +1 more source

A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity

iScience, 2018
Summary: Many xenobiotics can bind to off-target receptors and cause toxicity via the dysregulation of downstream transcription factors. Identification of subsequent off-target toxicity in these chemicals has often required extensive chemical testing in ...
Joseph Leedale, Kieran J. Sharkey, Helen E. Colley, Áine M. Norton, David Peeney, Chantelle L. Mason, Jean G. Sathish, Craig Murdoch, Parveen Sharma, Steven D. Webb   +9 more
doaj   +1 more source

An explorable model of an adverse outcome pathway of cytokine release syndrome related to the administration of immunomodulatory biotherapeutics and cellular therapies

Frontiers in Immunology
IntroductionCytokine release syndrome (CRS) is a potentially severe systemic inflammatory condition triggered by various immunomodulatory therapies, making understanding its pathogenesis critical for improving patient outcomes.Results/MethodsBy combining
Alexander Mazein, Oxana Lopata, Kristin Reiche, Kristin Reiche, Kristin Reiche, Katherina Sewald, Katherina Sewald, Miriam Alb, Christina Sakellariou, Patricia Gogesch, Hannah Morgan, Vanessa Neuhaus, Vanessa Neuhaus, Nhu-Nguyen Pham, Nhu-Nguyen Pham, Charline Sommer, Charline Sommer, Ethan Perkins, Ethan Perkins, Birgit Fogal, Muhammad Shoaib, Reinhard Schneider, Reinhard Schneider, Venkata Satagopam, Venkata Satagopam, Marek Ostaszewski, Marek Ostaszewski   +26 more
doaj   +1 more source

Harvesting the Promise of AOPs: An assessment and recommendations [PDF]

, 2018
The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals.
Ankley, Gerald T., Carusi, Annamaria, Davies, Mark R., De Grandis, Giovanni De, Escher, Beate I., Hodges, Geoff, Wheelan, Maurice, Willet, Catherine, Y. Leung, Kenneth M.   +8 more
core   +4 more sources