Results 31 to 40 of about 22,875,861 (325)
Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicity. [PDF]
Pharmacol Res Perspect, 2019 Generaux G +12 more
europepmc +3 more sources
Toxicology Research and Application, 2021 The objectives of this study were to increase PG exposure above concentrations tested by Suber et al. and use systems toxicology analysis of lung tissue to understand molecular events.
T. Langston +11 more
semanticscholar +1 more source
From Causal Networks to Adverse Outcome Pathways: A Developmental Neurotoxicity Case Study
Frontiers in Toxicology, 2022 The last decade has seen the adverse outcome pathways (AOP) framework become one of the most powerful tools in chemical risk assessment, but the development of new AOPs remains a slow and manually intensive process. Here, we present a faster approach for
Živa Ramšak +5 more
doaj +1 more source
TOXPANEL: A Gene-Set Analysis Tool to Assess Liver and Kidney Injuries
Frontiers in Pharmacology, 2021 Gene-set analysis is commonly used to identify trends in gene expression when cells, tissues, organs, or organisms are subjected to conditions that differ from those within the normal physiological range.
Patric Schyman +6 more
doaj +1 more source
Assessing network-based methods in the context of system toxicology
Frontiers in Pharmacology, 2023 Introduction: Network-based methods are promising approaches in systems toxicology because they can be used to predict the effects of drugs and chemicals on health, to elucidate the mode of action of compounds, and to identify biomarkers of toxicity ...
Jordi Valls-Margarit +5 more
doaj +1 more source
Systems bioengineering approaches for developmental toxicology
Computational and Structural Biotechnology Journal, 2023 Developmental toxicology is the field of study that examines the effects of chemical and physical agents on developing organisms. By using principles of systems biology and bioengineering, a systems bioengineering approach could be applied to study the ...
Beatriz Xavier Soares +2 more
doaj +1 more source
Systems toxicology approach for testing chemical cardiotoxicity in larval zebrafish.
Chemical Research in Toxicology, 2020 Transcriptomic approaches can give insight into molecular mechanisms underlying chemical toxicity and are increasingly being used as part of toxicological assessments.
Roman Li +10 more
semanticscholar +1 more source
Chemical Research in Toxicology, 2020 Diosbulbin B (DIOB) is an effective component of air potato yam with anti-tumor and anti-inflammatory activities, and it is the main toxic component leading to hepatotoxicity. However, the mechanism of its hepatotoxicity remains unclear.
H. Ji +8 more
semanticscholar +1 more source
Network-Based Methods for Prediction of Drug-Target Interactions
Frontiers in Pharmacology, 2018 Drug-target interaction (DTI) is the basis of drug discovery. However, it is time-consuming and costly to determine DTIs experimentally. Over the past decade, various computational methods were proposed to predict potential DTIs with high efficiency and ...
Zengrui Wu +3 more
doaj +1 more source
Systems biology and synthetic biology: A new epoch for toxicology research [PDF]
, 2014 Copyright © 2015 Mark T. Mc Auley et al. This is an open access article distributed under the Creative Commons Attribution License 3.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Choi, Hyunok +4 more
core +7 more sources