Results 41 to 50 of about 323,783 (333)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Multi-scale systems toxicology defines a KLF5-centered adverse outcome pathway linking DEHP exposure to pancreatic cancer progression and signaling programs relevant to therapy tolerance

Frontiers in Cell and Developmental Biology
Di(2-ethylhexyl) phthalate (DEHP) is a ubiquitous plasticizer implicated in pancreatic carcinogenesis, yet the molecular initiating events and adverse outcome pathways (AOPs) linking exposure to disease mechanisms remain poorly resolved.
Jihao Chen, Huaxin Pang, Jundan Wang, Junhua Guo, Ting Huang, Heran Zhou   +5 more
doaj   +1 more source

The effect of vitamin C on the erythrocyte antioxidant enzymes in intoxicated-lead rat offsprings [PDF]

, 2013
Objective: Lead exposure or lead poisoning is known to cause a large spectrum of physiological, biochemical, and behavioural disorders in animals.
Eshginia, S., Marjani, A.
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A Distributed Solution to the PTE Problem [PDF]

, 1999
Proceeding of: AAAI Spring Symposium on Predictive Toxicology, AAAI Press, Stanford, March 1999A wide panoply of machine learning methods is available for application to the Predictive Toxicology Evaluation (PTE) problem.
Borrajo Millán, Daniel, Elkan, Charles, Giráldez, J. Ignacio   +2 more
core   +2 more sources

The European Registered Toxicologist (ERT) : Current status and prospects for advancement [PDF]

, 2016
Acknowledgements We would like to thank the participants of the five workshops in which the issues presented in this paper were discussed and the revised guidelines prepared, as well as the EUROTOX Executive Committee and the societies of toxicology of ...
Basaran, Nursen, Blaauboer, Bas J., Bonefeld-Jørgensen, Eva Cecilie, Bourrinet, Philippe, Brueller, Werner, Claude, Nancy, Galli, Corrado L., Grönlund, Marie Haag, Gundert-Remy, Ursula, Håkansson, Helen, Johanna Zilliacus, Johanna, Kovatsi, Leda, Leconte, Isabelle, Liesivuori, Jyrki, Lindeman, Brigitte, Lison, Dominique, Lopez, Emma Martinez, Matovic, Vesna, Michel, Cecile, Miranda, Joana P., Murias, Marek, Scheepers, Paul T.J., Schulte-Hermann, Rolf, Stanley, Lesley, Teixeira, Joao Paulo, Tsatsakis, Aristidis, Wallace, Heather M., Wilks, Martin F.   +27 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Prenatal arsenic exposure induces immunometabolic alteration and renal injury in rats

Frontiers in Medicine, 2023
Arsenic (As) exposure is progressively associated with chronic kidney disease (CKD), a leading public health concern present worldwide. The adverse effect of As exposure on the kidneys of people living in As endemic areas have not been extensively ...
Radha Dutt Singh, Radha Dutt Singh, Ratnakar Tiwari, Vineeta Sharma, Vineeta Sharma, Hafizurrahman Khan, Hafizurrahman Khan, Siddhartha Gangopadhyay, Siddhartha Gangopadhyay, Sukhveer Singh, Sukhveer Singh, Kavita Koshta, Kavita Koshta, Shagun Shukla, Nidhi Arjaria, Kapil Mandrah, Kapil Mandrah, Pankaj Ramji Jagdale, Satyakam Patnaik, Satyakam Patnaik, Somendu Kumar Roy, Somendu Kumar Roy, Dhirendra Singh, Ashok Kumar Giri, Vikas Srivastava, Vikas Srivastava   +25 more
doaj   +1 more source

A comparison of the results from intra-pleural and intra-peritoneal studies with those from inhalation and intratracheal tests for the assessment of pulmonary responses to inhalable dusts and fibres. [PDF]

, 2016
The aim of this paper is to compare results from inhalation studies with those from intraperitoneal and intrapleural tests, where available, for a number of fibrous and particulate test materials.
Bevan, Ruth, Drummond, Gail, Harrison, Paul   +2 more
core   +2 more sources