Results 41 to 50 of about 22,875,861 (325)

BAP1 in cancer: epigenetic stability and genome integrity

Discover Oncology, 2022
Mutations in BAP1 have been identified in a hereditary cancer predisposition syndrome and in sporadic tumours. Individuals carrying familiar BAP1 monoallelic mutations display hypersusceptibility to exposure-associated cancers, such as asbestos-driven ...
Sabrina Caporali, Alessio Butera, Ivano Amelio   +2 more
doaj   +1 more source

Role of Tunable Gold Nanostructures in Cancer Nanotheranostics: Implications on Synthesis, Toxicity, Clinical Applications and Their Associated Opportunities and Challenges

Journal of Nanotheranostics, 2023
The existing diagnosis and treatment modalities have major limitations related to their precision and capability to understand several stages of disease development.
Akash Kumar, Nabojit Das, Raja Gopal Rayavarapu   +2 more
doaj   +1 more source

Smart Platinum Nanostructures: A Journey from Synthesis to Advanced Theranostic Applications

Journal of Nanotheranostics, 2023
A significant paradigm shift has been observed in the past decade in the area of theranostics owing to the development of various isotropic and anisotropic metal nanostructures, simultaneous with improved imaging modalities. Platinum-based nanostructures
Akash Kumar, Nabojit Das, Raja Gopal Rayavarapu   +2 more
doaj   +1 more source

Characterization of the interferences of systemic azole antifungal drugs with adrenal steroid biosynthesis using H295R cells and enzyme activity assays

Current Research in Toxicology, 2023
Azole antifungals, designed to inhibit fungal CYP51, have a liability to inhibit human CYP enzymes. Whilst drug-metabolizing CYPs are covered in preclinical safety assessment, those metabolizing endogenous bioactive molecules are usually not ...
Marie-Christin Jäger, Friedrich L. Joos, Denise V. Winter, Alex Odermatt   +3 more
doaj   +1 more source

In Vitro Toxicology Systems [PDF]

, 2013
There has been a dramatic increase in the development and use of in vitro systems in all types of biological disciplines but particularly in pharmacology and toxicology.

core   +1 more source

3D human microvessel-on-a-chip model for studying monocyte-to-endothelium adhesion under flow - application in systems toxicology.

ALTEX, 2019
Lifestyle and genetic factors can lead to the development of atherosclerosis and, ultimately, cardiovascular adverse events. Rodent models are commonly used to investigate mechanism(s) of atherogenesis. However, the 3Rs principles, aiming to limit animal
C. Poussin, B. Kramer, H. Lanz, A. van den Heuvel, Alexandra Laurent, T. Olivier, M. Vermeer, Dariusz Peric, Karin Baumer, Rémi H. J. Dulize, E. Guedj, N. Ivanov, M. Peitsch, J. Hoeng, J. Joore   +14 more
semanticscholar   +1 more source

Insect in vitro System for Toxicology Studies — Current and Future Perspectives

Frontiers in Toxicology, 2021
In vitro cell culture practices are valuable techniques to understand the mechanisms behind vital in vivo biological processes. In vitro cells have helped us to attain a deeper understanding of functions and mechanisms conserved in the course of ...
Sheeja Cc, Damodaran Arun, Lekha Divya
doaj   +1 more source

COMPRENDO: Focus and approach [PDF]

, 2006
Tens of thousands of man-made chemicals are in regular use and discharged into the environment. Many of them are known to interfere with the hormonal systems in humans and wildlife.
Axel Allera, Candia Carnevali MD, Charles Tyler, Christoph van Ballegoy, Cinta Porte, Copeland BJ, Daniela Candia Carnevali, David Hala, Dietrich Klingmüller, European Parliament and the Council of the European Union, Francesca Ciceri, Gemma Janer, Ilka Lutz, Isabella King, Jean Bachmann, Jerzy Falandysz, Jörg Oehlmann, Kresten Ole Kusk, Leah Wollenberger, Marian Rand-Weaver, Michela Sugni, Nicola Beresford, Pia Berntsson, Ramon Levada, Roger Jeannot, Ronny van Aerle, Silvana Galassi, Stina Oredsson, Susan Jobling, Susan Lo, Tagatz ME, Thierry Dagnac, Triantafyllos Albanis, Ulrike Schulte-Oehlmann, Vasilis Sakkas, Werner Kloas   +35 more
core   +4 more sources

Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology

Archives of Toxicology, 2019
We previously proposed a systems toxicology framework for in vitro assessment of e-liquids. The framework starts with the first layer aimed at screening the potential toxicity of e-liquids, followed by the second layer aimed at investigating the toxicity-
A. Iskandar, Filippo Zanetti, D. Marescotti, B. Titz, A. Sewer, A. Kondylis, P. Leroy, V. Belcastro, L. O. Torres, S. Acali, Shoaib Majeed, S. Steiner, Keyur C Trivedi, E. Guedj, Céline Merg, T. Schneider, S. Frentzel, F. Martin, N. Ivanov, M. Peitsch, J. Hoeng   +20 more
semanticscholar   +1 more source

In silico biomarker analysis of the adverse effects of perfluorooctane sulfonate (PFOS) exposure on the metabolic physiology of embryo-larval zebrafish

Frontiers in Systems Biology
Perfluorooctane sulfonate (PFOS) is a ubiquitous pollutant in global aquatic ecosystems with increasing concern for its toxicity to aquatic wildlife through inadvertent exposures.
Rayna M. Nolen, Lene H. Petersen, Karl Kaiser, Karl Kaiser, Antonietta Quigg, Antonietta Quigg, Antonietta Quigg, David Hala   +7 more
doaj   +1 more source