Results 71 to 80 of about 22,875,861 (325)

Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action [PDF]

, 2014
Summary The Human Toxicology Project Consortium (HTPC) was created to accelerate implementation of the science and policies required to achieve a pathway-based foundation for toxicology as articulated in the 2007 National Research Council report on ...
ANDERSEN Melvin E., AVIGAN Mark, CAVERLY RAE Jessica, DUCHÉ Daniel, GOYAK Katy, HARTUNG T., JAESCHKE Hartmut, KLEENSANG Andre, LANDESMANN Brigitte, MINSAVAGE Gary, ROWAN Andrew, SCHULTZ Terry, SEED Jennifer, SENIOR John, SHAH Imran, SUBRAMANIAN Kas, TOOLE Colleen, VINKEN Mathieu, WATKINS Paul, WESTMORELAND Carl, WILLETT Catherine   +20 more
core   +1 more source

Primary Human Tissue Models for Metabolic Dysfunction‐Associated Liver Disease ‐ toward Streamlining Drug Discovery with Patient‐Derived Assays

Advanced Biology, EarlyView.
The review provides a critical up‐to‐date overview of the current landscape of human in vitro models for fatty liver disease, including spheroids, organoids, organ‐on‐a‐chip systems, bioprinted liver constructs and precision‐cut liver slices. Their utility for faithfully modeling different stages of MASLD and MASH are evaluated and their compatibility ...
Sonia Youhanna, Nayere Taebnia, Yingxin Liang, Ningtao Cheng, Yi Wang, Maurice Michel, Volker M. Lauschke   +6 more
wiley   +1 more source

Development and Validation of a Highly Sensitive LC-MS/MS Method for the Analysis of Bile Acids in Serum, Plasma, and Liver Tissue Samples

Metabolites, 2020
Bile acids control lipid homeostasis by regulating uptake from food and excretion. Additionally, bile acids are bioactive molecules acting through receptors and modulating various physiological processes. Impaired bile acid homeostasis is associated with
Cristina Gómez, Simon Stücheli, Denise V. Kratschmar, Jamal Bouitbir, Alex Odermatt   +4 more
doaj   +1 more source

A comparison of the results from intra-pleural and intra-peritoneal studies with those from inhalation and intratracheal tests for the assessment of pulmonary responses to inhalable dusts and fibres. [PDF]

, 2016
The aim of this paper is to compare results from inhalation studies with those from intraperitoneal and intrapleural tests, where available, for a number of fibrous and particulate test materials.
Bevan, Ruth, Drummond, Gail, Harrison, Paul   +2 more
core   +2 more sources

Crowd-Sourced Verification of Computational Methods and Data in Systems Toxicology: A Case Study with a Heat-Not-Burn Candidate Modified Risk Tobacco Product.

Chemical Research in Toxicology, 2017
Systems toxicology intends to quantify the effect of toxic molecules in biological systems and unravel their mechanisms of toxicity. The development of advanced computational methods is required for analyzing and integrating high throughput data ...
C. Poussin, V. Belcastro, F. Martin, S. Boué, M. Peitsch, J. Hoeng   +5 more
semanticscholar   +1 more source

Fluorophobic Effect Enables Selective Detection of PFAS in Water with Electrolyte‐Gated Organic Transistors

Advanced Functional Materials, EarlyView.
PerFluoroAlkyl Substances (PFAS) are responsible of major and persistent environmental pollution worldwide. This work demonstrates an ultra‐sensitive sensor for PFAS based on an organic transistor whose gate is functionalized with a binary self‐assembled monolayer containing a perfluorinated molecule.
Rian Zanotti, Marcello Berto, Matteo Sensi, Alessandro Paradisi, Eleonora Veronese, Lucia Pasquato, Carlo Augusto Bortolotti, Pierangelo Metrangolo, Fabio Biscarini   +8 more
wiley   +1 more source

Functional Materials for Environmental Energy Harvesting in Smart Agriculture via Triboelectric Nanogenerators

Advanced Functional Materials, EarlyView.
This review explores functional and responsive materials for triboelectric nanogenerators (TENGs) in sustainable smart agriculture. It examines how particulate contamination and dirt affect charge transfer and efficiency. Environmental challenges and strategies to enhance durability and responsiveness are outlined, including active functional layers ...
Rafael R. A. Silva, Giulio Fatti, Emanuel Carlos, Guilherme Ferreira, Sumita Goswami, Suman Nandy, Luiz H. C. Mattoso, Elvira Fortunato, Caio G. Otoni, Rodrigo Martins   +9 more
wiley   +1 more source

Comparison of monoamine oxidase inhibition by cigarettes and modified risk tobacco products

Toxicology Reports, 2019
The adverse effects of cigarette smoking are well documented, and the two main strategies for reducing smoking prevalence are prevention of smoking initiation and promotion of smoking cessation.
Marco van der Toorn, Kyoko Koshibu, Walter K. Schlage, Shoaib Majeed, Pavel Pospisil, Julia Hoeng, Manuel C. Peitsch   +6 more
doaj   +1 more source

Developmental Exposure to Endocrine Disrupting Chemicals and Its Impact on Cardio-Metabolic-Renal Health

Frontiers in Toxicology, 2021
Developmental origin of health and disease postulates that the footprints of early life exposure are followed as an endowment of risk for adult diseases.
Radha Dutt Singh, Kavita Koshta, Kavita Koshta, Ratnakar Tiwari, Hafizurrahman Khan, Vineeta Sharma, Vikas Srivastava, Vikas Srivastava   +7 more
doaj   +1 more source

Comparative Analysis Of Zebrafish And Planarian Model Systems For Developmental Neurotoxicity Screens Using An 87-Compound Library [PDF]

, 2019
There is a clear need to establish and validate new methodologies to more quickly and efficiently screen chemicals for potential toxic effects, particularly on development. The emergence of alternative animal systems for rapid toxicology screens presents
Collins, Eva-Maria S., Hagstrom, D., Tanguay, R., Truong, L., Zhang, S.   +4 more
core   +1 more source