Results 291 to 300 of about 17,484,371 (316)
The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease [PDF]
, 2019 Atkins, Annette R. +14 more
core +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
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Science, 2003
We depend on the efficiency of our adaptive immune system to combat pathogen invaders. Part of this protective response includes development of CD4 and CD8 effector T cells. As Hatton and Weaver discuss in their Perspective, key transcription factors regulating CD4 effector T cell development have been identified, whereas those governing the ...
Robin D. Hatton, Casey T. Weaver
openaire +1 more source
We depend on the efficiency of our adaptive immune system to combat pathogen invaders. Part of this protective response includes development of CD4 and CD8 effector T cells. As Hatton and Weaver discuss in their Perspective, key transcription factors regulating CD4 effector T cell development have been identified, whereas those governing the ...
Robin D. Hatton, Casey T. Weaver
openaire +1 more source
T-bet+ Memory B Cells Stay in Place
Immunity, 2020Memory B cells (MBCs) expressing the transcription factor T-bet have been described in normal and dysregulated immune responses. In this issue of Immunity, Johnson et al. report that T-bet+ MBCs, formed in response to a primary influenza infection, contribute to protective antibody titers and persist mainly in the spleen with restricted trafficking ...
Sarah F, Andrews, Susan, Moir
openaire +2 more sources
The role of T-bet in obesity: lack of T-bet causes obesity in male mice
The Journal of Nutritional Biochemistry, 2013The association of T helper (Th) 1 cells with obesity is well documented in both animals and humans. The T-box transcription factor (T-bet) is known as the transcription factor that is responsible for the development of Th1 cells. However, the role of T-bet in obesity has never been elucidated.
Kyu-Yeob, Kim +2 more
openaire +2 more sources
STAT6 inhibits T-bet-independent Th1 cell differentiation
Biochemical and Biophysical Research Communications, 2009STAT6 plays critical roles in Th2 cell differentiation, whereas STAT4 and T-bet are important for Th1 cell differentiation. However, it is still largely unknown about the cross talk of these transcription factors during Th1/Th2 cell differentiation. To further address the regulatory mechanisms underlying Th1/Th2 cell differentiation, we generated the ...
Tomohiro, Tamachi +9 more
openaire +2 more sources
T-bet+ B cells exacerbate obesity-related metabolic disease
Trends in Immunology, 2022B cells are associated with the development of obesity-associated metabolic disease. Recently, Hägglöf, Vanz, et al. identified a novel obesity-related subset of B cells that are demarcated by the transcription factor T-bet and their pathogenic ability to worsen metabolic disease outcomes.
Saad Khan, Daniel A. Winer
openaire +2 more sources
Science immunology, 2020
A GM-CSF+ T helper cell subset develops from naïve precursors and switch to a TH1 phenotype during neuroinflammation. Poised for pathogenicity Production of GM-CSF by T helper cells not only guides adaptive immune responses but also can contribute to the
J. Rasouli +15 more
semanticscholar +1 more source
A GM-CSF+ T helper cell subset develops from naïve precursors and switch to a TH1 phenotype during neuroinflammation. Poised for pathogenicity Production of GM-CSF by T helper cells not only guides adaptive immune responses but also can contribute to the
J. Rasouli +15 more
semanticscholar +1 more source
Deubiquitination and stabilization of T-bet by USP10
Biochemical and Biophysical Research Communications, 2014The T-box transcriptional factor T-bet is crucial in the development, differentiation and function of Th1 cells. It drives Th1 immune response primarily through promoting expression of Th1 hallmark cytokine IFN-γ. Although T-bet was found associated with many immune-mediated diseases such as asthma and systemic sclerosis, little is known about the ...
Lina, Pan +7 more
openaire +2 more sources