Results 301 to 310 of about 17,484,371 (316)
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T-bet B or not T-bet B, is that the question in obesity-related metabolic disease?
Cell Metabolism, 2022Obesity is linked to inflammation and downstream metabolic dysregulation. In this issue of Cell Metabolism, Hägglöf et al. show that iNKT cells enable the accumulation of T-bet+ B cells in white adipose tissue, which in turn produce chemokine and antibody mediators that exacerbate the onset and severity of metabolic disease.
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T-bet deficiency attenuates cardiac remodelling in rats
Basic Research in Cardiology, 2018Previous studies have suggested the involvement of CD4 + T lymphocytes in cardiac remodelling. T-bet can direct Th1 lineage commitment. This study aimed to investigate the functional significance of T-bet in cardiac remodelling induced by pressure overload using T-bet global knockout rats.
Zhen-Guo, Ma +7 more
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Trawling for treasure: tales of T-bet
Nature Immunology, 2007Discovering the transcription factors that direct lineage commitment in the T helper cell was a formidable task. Laurie Glimcher describes how she and Susanne Szabo hunted down T-bet, a transcription factor that is a 'master regulator' of commitment to the T helper type 1 lineage.
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Overexpression of T‐bet gene regulates murine autoimmune arthritis
Arthritis & Rheumatism, 2011AbstractObjectiveTo clarify the role of T‐bet in the pathogenesis of collagen‐induced arthritis (CIA).MethodsT‐bet–transgenic (Tg) mice under the control of the CD2 promoter were generated. CIA was induced in T‐bet–Tg mice and wild‐type C57BL/6 (B6) mice.
Yuya, Kondo +11 more
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T-bet deficiency decreases susceptibility to experimental myasthenia gravis
Experimental Neurology, 2009T-bet, a tissue-specific transcription factor, controls T helper 1 (Th1) cell differentiation and IFN-production. Given the reciprocal relationship between Th1 and other types of helper T cells, we hypothesized that T-bet impacts multiple helper and regulatory T (Treg) cells, thereby influencing the magnitude of autoimmune disease.
Ruolan, Liu +4 more
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CD4+T-bet+, CD4+pSTAT3+ and CD8+T-bet+ T cells accumulate in peripheral blood during NZB treatment
Multiple Sclerosis Journal, 2010Circulating T cells and monocytes expressing T-bet, pSTAT1 and pSTAT3 increase in relapsing–remitting multiple sclerosis (RRMS) during relapse. Natalizumab (NZB) is an effective drug in RRMS, but exacerbation of the disease after its discontinuation has been described in some patients.
Frisullo G +6 more
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[T-bet in peripheral T-cell lymphoma].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2018Objective: To evaluate the expression of transcription factor T-bet (T-box expressed in T cells) and explore its effects on prognosis in peripheral T-cell lymphoma (PTCL). Methods: This study included 109 previously untreated patients diagnosed with PTCL in the pathology system at Peking Union Medical College Hospital from 2007 to 2013. Formalin-fixed,
Z, Wang, D B, Zhang, W, Zhou
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Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
Nature Immunology, 2005A. Intlekofer +20 more
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T-bet+ B cells promote metabolic disease
Nature Reviews Endocrinology, 2022openaire +2 more sources