Results 91 to 100 of about 14,321,563 (290)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Transcription Factor T-bet Regulates Mucosal T Cell Activation in Experimental Colitis and Crohn's Disease [PDF]

The Journal of Experimental Medicine, 2002
The balance between pro and antiinflammatory cytokines secreted by T cells regulates both the initiation and perpetuation of inflammatory bowel diseases (IBD). In particular, the balance between interferon (IFN)-γ/interleukin (IL)-4 and transforming growth factor (TGF)-β activity controls chronic intestinal inflammation. However, the molecular pathways
Neurath, M.F., Weigmann, B., Finotto, S., Glickman, J., Nieuwenhuis, E., Iijima, H., Mizoguchi, A., Mizoguchi, E., Mudter, J., Galle, P.R., Bhan, A., Autschbach, F., Sullivan, B.M., Szabo, S.J., Glimcher, L.H., Blumberg, R.S.   +15 more
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The membrane-tethered transcription factor ANAC089 serves as redox-dependent suppressor of stromal ascorbate peroxidase gene expression [PDF]

, 2012
Klein P, Seidel T, Stöcker B, Dietz K-J. The membrane-tethered transcription factor ANAC089 serves as redox-dependent suppressor of stromal ascorbate peroxidase gene expression. Frontiers in Plant Science.
Thorsten Seidel, Dietz, Karl-Josef, Benedikt eStöcker, Benedikt Stöcker, Peter eKlein, Klein, Peter, Thorsten eSeidel, Peter Klein, Karl-Josef Dietz, Seidel, Thorsten, Stöcker, Benedikt, Karl-Josef eDietz   +11 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

YY1 regulation by miR-124-3p promotes Th17 cell pathogenicity through interaction with T-bet in rheumatoid arthritis

JCI Insight, 2021
Th17 cells are involved in rheumatoid arthritis (RA) pathogenesis. Our previous studies have revealed that transcription factor Yin Yang 1 (YY1) plays an important role in the pathogenic mechanisms of RA.
Jinpiao Lin, Jifeng Tang, Junyu Lin, Yujue He, Ziqing Yu, Renquan Jiang, Bin Yang, Qishui Ou   +7 more
doaj   +1 more source

Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease [PDF]

, 2009
Prolonged Ca(2+) entry through Ca(2+) release-activated Ca(2+) (CRAC) channels is crucial in activating the Ca(2+)-sensitive transcription factor NFAT, which is responsible for directing T cell proliferation and cytokine gene expression.
Brown J. T, Kaur R, P. G. McLean, L. Scott, MacDonald, Thomas T, A. D. Sabatino, Kruidenier, Laurens, Scott, Laurie, Gunthorpe MJ, MacDonald TT, K. Lee, Lee, Kevin, Wilde J. I, Morisset VD, V. D. Morisset, Morisset, Valerie D, C. H. Knowles, Morisset V. D, Brown JT, J. P. Spencer, Wilde JI, Kruidenier L., N. Sengupta, R. Kaur, Knowles CH, Biancheri, Paolo, Mclean P. G, CORAZZA, GINO ROBERTO, Leakey NA, McLean PG, Rovedatti, Laura, Wilde, Jonathan I, Gunthorpe M. J, J. T. Brown, Lee K, Spencer JP, Scott L, Macdonald T. T, Knowles C. H, Brown, Jon T, Sengupta, Neel, Spencer, Jonathan P, Spencer J. P, T. T. MacDonald, J. I. Wilde, Sengupta N, McLean, Peter G, Kaur, Rejbinder, M. J. Gunthorpe, Leakey, Nicholas A B, Corazza, Gino R, L. Kruidenier, Di Sabatino, Antonio, Knowles, Charles H, N. A. B, Leakey N. A, Gunthorpe, Martin J   +56 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

T-helper Cell Type-1 Transcription Factor T-Bet Is Down-regulated in Type 1 Diabetes

Iranian Journal of Allergy, Asthma and Immunology, 2016
T cells have been identified as key players in the pathogenesis of type 1 diabetes. However, the exact role of T-cell subpopulations in this pathway is presently unknown.
Hajar Vaseghi, Mohammad Hossein Sanati, Zohreh Jadali   +2 more
doaj