Results 101 to 110 of about 14,321,563 (290)

Levels of Interferon-Gamma and Transcription Factor T-Bet in Progressive Periodontal Lesions in Patients With Chronic Periodontitis [PDF]

, 2009
Background: Periodontitis is an infection with an episodic pattern of tissue-support destruction. During the generation of a primary CD4+ T helper 1 (Th1) response, interferon-gamma (IFN-g) acts as a positive regulator by selectively inducing Th1 ...
Dutzan Muñoz, Nicolás, Dezerega Piwonka, Andrea, Aguillón Gutiérrez, Juan Carlos, Hernández Ríos, Emma, Rivera Escobar, Oriana, Silva Steffens, Nora, Puente Piccardo, Javier, Pozo, Patricia, Gamonal Aravena, Jorge Antonio, Vernal Astudillo, Rolando   +9 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells [PDF]

, 2012
mTORC1 (mammalian target of rapamycin complex 1) controls transcriptional programs that determine CD8 cytolytic T cell (CTL) fate. In some cell systems, mTORC1 couples phosphatidylinositol-3 kinase (PI3K) and Akt to the control of glucose uptake and ...
Julia Rolf, Sinclair, Linda V., David K. Finlay, Andrey A. Panteleyev, Rolf, Julia, Okkenhaug, Klaus, Klaus Okkenhaug, Doreen A. Cantrell, Cantrell, Doreen A., Rosenzweig, Ella, Jens L. Hukelmann, Feijoo-Carnero, Carmen, Carmen Feijoo-Carnero, Panteleyev, Andrey A., Hukelmann, Jens L., Linda V. Sinclair, Finlay, David K., Ella Rosenzweig   +17 more
core   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

T-bet deficiency and Hic1 induction override TGF-β-dependency in the formation of CD103+ intestine-resident memory CD8+ T cells

Cell Reports
Summary: Transforming growth factor β (TGF-β) represents a well-established signal required for tissue-resident memory T cell (TRM) formation at intestinal surfaces, regulating the expression of a large collection of genes coordinately promoting ...
Liwen Wang, Shruti Mishra, Kenneth Ka-Ho Fan, Sara Quon, Guo Li, Bingfei Yu, Wei Liao, Yong Liu, Xin Zhang, Yuanzheng Qiu, Yue Li, Ananda W. Goldrath, Chaoyu Ma, Nu Zhang   +13 more
doaj   +1 more source

Treatment of allergic airway inflammation and hyperresponsiveness by imiquimod modulating transcription factors T-bet and GATA-3

Chinese Medical Journal, 2006
Imiquimod is an imidazoquinoline, which class of compounds are known to have antiviral and antitumoural properties. In recent studies, it was shown that imiquimod modulates the T helper cell type Th1/Th2 response by inducing the production of Th1 cytokines like IFN-gamma, and by inhibiting the Th2 cytokines like interleukin (IL)-4.
Tao, Bian, Kai-sheng, Yin, Shu-xian, Jin, Xi-long, Zhang, Jin-yong, Zhou, Xiu-qin, Ma, Jing-jing, Hu, Wei, De   +7 more
openaire   +2 more sources

The Transcription Factor T-bet Is Induced by IL-15 and Thymic Agonist Selection and Controls CD8αα+ Intraepithelial Lymphocyte Development [PDF]

, 2014
SummaryCD8αα+ intraepithelial lymphocytes (IELs) are instrumental in maintaining the epithelial barrier in the intestine. Similar to natural killer cells and other innate lymphoid cells, CD8αα+ IELs constitutively express the T-box transcription factor T-
Tanriver, Yakup, Arnold, Sebastian J., Kofoed-Nielsen, Michael, Ebert, Karolina, Diefenbach, Andreas, Hernandez, Pedro P., Klose, Christoph S.N., d’Hargues, Yannick, Ripka, Juliane F., Palmer, Ed, Blatz, Katharina   +10 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division [PDF]

, 2011
SummaryPolarized segregation of proteins in T cells is thought to play a role in diverse cellular functions including signal transduction, migration, and directed secretion of cytokines.
Jane Oliaro, Gary A. Koretzky, Steven L. Reiner, Maria L. Ciocca, Bogdan I. Florea, Steinel, Natalie C., Berg, Leslie J., Chang, John T., Sarah M. Russell, Herman S. Overkleeft, DeJong, Caitlin S., Erin C. Mooney, Leslie J. Berg, Koretzky, Gary A., Caitlin S. DeJong, Palanivel, Vikram R., Ichiko Kinjyo, Jordan, Martha S., John T. Chang, Ciocca, Maria L., Mooney, Erin C., Russell, Sarah M., Florea, Bogdan I., Catherine C. Yin, McClurkin, Courtney E., Kinjyo, Ichiko, Overkleeft, Herman S., Natalie C. Steinel, Reiner, Steven L., Yin, Catherine C., Vikram R. Palanivel, Kim, Jiyeon S., Oliaro, Jane, Courtney E. McClurkin, Jiyeon S. Kim, Martha S. Jordan   +35 more
core   +1 more source