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Significance of Epigenetic Alteration in Cancer-Associated Fibroblasts on the Development of Carcinoma. [PDF]

open access: yesInt J Mol Sci
Gao H   +8 more
europepmc   +1 more source

Identification of BET inhibitors (BETi) against solitary fibrous tumor (SFT) through high-throughput screening (HTS). [PDF]

open access: yesNeoplasia
Mondaza-Hernandez JL   +11 more
europepmc   +1 more source

Transcription factor expression in B-cell precursor-leukemia cell lines: preferential expression of T-bet

open access: yesTranscription factor expression in B-cell precursor-leukemia cell lines: preferential expression of T-bet
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T‐bet transcription factor in cardiovascular disease: Attenuation or inflammation factor?

Journal of Cellular Physiology, 2018
AbstractT‐bet is a major transcription factor increasing inflammatory responses in the immune system. Recently, it has been shown that this factor leads to inflammation in cardiovascular disease (CVD). In this study, we examine the dual role of T‐bet in inducing and suppressing inflammatory reactions as well as angiogenesis induction due to ...
Habib Haybar   +4 more
openaire   +2 more sources

Transcription Factors T-bet and GATA-3 Regulate Development of Airway Remodeling

American Journal of Respiratory and Critical Care Medicine, 2006
Airway remodeling is an important feature of chronic asthma that causes irreversible airflow obstruction. Although asthma is considered to be a Th2 disease, the role of T-bet and GATA-3, the key transcription factors for differentiation toward Th1 and Th2 cells, in the pathogenesis of airway remodeling is poorly understood.We therefore examined the ...
Takumi, Kiwamoto   +13 more
openaire   +2 more sources

Transcription factor T-bet drives the pathogenesis of TH17-mediated neuroinflammation

The Journal of Immunology, 2018
Abstract Emergingdata demonstrate that exposure to pro-inflammatory cytokines IL-12 and IL-23 convertsnon-pathogenic IL-17A-producing CD4+ TH17 cells intopathogenic effectors, though the molecular mechanism remains undefined.
Tiffany Taylor Loo   +2 more
openaire   +1 more source

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