B-1 cells contribute to increased total IgM and shape IgG autoreactivity profiles in Lyn-/- mice but are not a major source of lupus-associated pathogenic autoantibodies. [PDF]
Ottens K, Satterthwaite AB.
europepmc +1 more source
The Immunogenetic Landscape of Allergic Rhinitis: from Cellular Effectors to Gene Regulation and Targeted Therapies. [PDF]
Zhang X +8 more
europepmc +1 more source
From chaos to control: Nobel insights in regulatory T cells and immune tolerance. [PDF]
Estrada Brull A, Joller N.
europepmc +1 more source
Significance of Epigenetic Alteration in Cancer-Associated Fibroblasts on the Development of Carcinoma. [PDF]
Gao H +8 more
europepmc +1 more source
Identification of BET inhibitors (BETi) against solitary fibrous tumor (SFT) through high-throughput screening (HTS). [PDF]
Mondaza-Hernandez JL +11 more
europepmc +1 more source
IL17-deficient NOD mice are protected from autoimmune diabetes due to decreased antigen presentation and T cell activation. [PDF]
Pearson JA +5 more
europepmc +1 more source
openaire
Related searches:
T‐bet transcription factor in cardiovascular disease: Attenuation or inflammation factor?
Journal of Cellular Physiology, 2018AbstractT‐bet is a major transcription factor increasing inflammatory responses in the immune system. Recently, it has been shown that this factor leads to inflammation in cardiovascular disease (CVD). In this study, we examine the dual role of T‐bet in inducing and suppressing inflammatory reactions as well as angiogenesis induction due to ...
Habib Haybar +4 more
openaire +2 more sources
Transcription Factors T-bet and GATA-3 Regulate Development of Airway Remodeling
American Journal of Respiratory and Critical Care Medicine, 2006Airway remodeling is an important feature of chronic asthma that causes irreversible airflow obstruction. Although asthma is considered to be a Th2 disease, the role of T-bet and GATA-3, the key transcription factors for differentiation toward Th1 and Th2 cells, in the pathogenesis of airway remodeling is poorly understood.We therefore examined the ...
Takumi, Kiwamoto +13 more
openaire +2 more sources
Transcription factor T-bet drives the pathogenesis of TH17-mediated neuroinflammation
The Journal of Immunology, 2018Abstract Emergingdata demonstrate that exposure to pro-inflammatory cytokines IL-12 and IL-23 convertsnon-pathogenic IL-17A-producing CD4+ TH17 cells intopathogenic effectors, though the molecular mechanism remains undefined.
Tiffany Taylor Loo +2 more
openaire +1 more source

