Results 241 to 250 of about 14,321,563 (290)

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

Histone modifications across cancers: mechanisms, therapy and clinical translation. [PDF]

Mol Cancer
Lu P, Chan YT, Kwok CF, Li Q, Jiang Z, Xu L, Feng Z, Yuan H, Zou J, Xun Y, Fong TL, Che CM, Wang N.   +12 more
europepmc   +1 more source

Use of the “Ru‐1O2‐Hydrazide” System Catalyzed by Metallic Ruthenium Complexes to Decipher the Interaction Between Microbes and Host Cancer Cells

Advanced Science, EarlyView.
ABSTRACT The dynamic interplay between bacteria and host cancer cells plays a critical role in tumor microenvironment modulation, bacterial pathogenesis, and potential oncotherapy applications. However, traditional methods often fail to capture transient or spatially restricted molecular interactions at the bacteria‐cancer cell interface.
Amin Sun, Kaihong Wang, Haifu Sun, Kemei Tao, Xiang Li, Xiuhua Zhao, Shuang Qiu   +6 more
wiley   +1 more source

BET inhibition blunts antibody production and macrophage-mediated fibrosis to restore lung function in murine cGVHD.

Blood
Kumar R, Neidemire-Colley L, Garfinkle EAR, Steere C, Surana S, Murray A, Giordano G, Martin O, Woodbury ED, Rivaldi A, Singh S, Corps K, Lederer K, Karunasiri M, Gorr MW, Wold LE, Sehgal L, Oestreich KJ, Grieselhuber NR, de Lima MJ, Blazar BR, Maillard I, Miller KE, Choe HK, Ranganathan P.   +24 more
europepmc   +1 more source

Human leukocyte extract enhances albendazole efficacy against Echinococcus multilocularis in mice by reducing parasitic microRNAs, myeloid and lymphoid immunosuppressive cells. [PDF]

PLoS Negl Trop Dis
Hrčková G, Dvorožňáková E, Mudroňová D, Jurčacková Z, Mačak Kubašková T, Petrová M, Bardelčíková A.   +6 more
europepmc   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Estrogen and progesterone-mediated differential modulation of CD4⁺ T-cell pathogenicity in rheumatoid arthritis. [PDF]

Front Immunol
Jha R, Shaw SK, Bhattacharya G, Behera H, Pattanaik C, Sengupta S, Barik PK, Parida JR, Padhan P, Devadas S.   +9 more
europepmc   +1 more source

Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature

Advanced Science, EarlyView.
A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo, Yangyang Zhang, Yongcheng Jin, Siwei Deng, Yongqi Chen, Zheng Feng, Hao Wen, Liu Wang, Yilin Li, Fanghong Ou, Yong Shen, Haiming Li, Tianyao Zhou, Xingzhu Ju, Xiaohua Wu   +14 more
wiley   +1 more source

An updated overview of alkaloids for the prevention and treatment of metabolic dysfunction-associated steatotic liver disease. [PDF]

Front Pharmacol
Wang J, Zhang Y, Sun S, Hu L, Yang D.
europepmc   +1 more source

Matrix Stiffness Induces Endothelial Network Senescence

Advanced Science, EarlyView.
Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Jiyeon Song, Alexandra N. Rindone, Ya Guan, Connor D. Amelung, Prarthana Sanjay Daswani, Jennifer H. Elisseeff, Sharon Gerecht   +6 more
wiley   +1 more source