Results 251 to 260 of about 14,321,563 (290)

Epigenetic Modulators and Immunotherapy in Malignant Melanoma. [PDF]

Oncol Res
Anestopoulos I, Kyriakou S, Deligiorgi M, Trafalis DT, Botaitis S, Franco R, Pappa A, Panayiotidis MI.   +7 more
europepmc   +1 more source

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

Green Tea Catechin Metabolite 5‑(3',5'-Dihydroxyphenyl)-γ-valerolactone Enhances the Antitumor Efficacy of Immune Checkpoint Blockade by Priming Type‑1 Immunity. [PDF]

ACS Pharmacol Transl Sci
Zhang Y, Kawamoto R, Kumazoe M, Lee S, Fujimura Y, Takagaki A, Tomioka R, Suzuki M, Tachibana H.   +8 more
europepmc   +1 more source

CTHRC1⁺ cancer associated-fibroblasts promotes malignant progression of bladder cancer cells via inducing an immunosuppressive tumor microenvironment. [PDF]

Front Immunol
Wang M, Lin M, Wang Y.
europepmc   +1 more source

Cohesin-mediated loop extrusion and enhancer-associated factors additively contribute to <i>Sox2</i> looping with its distal enhancer. [PDF]

Genes Dev
Martinovic M, Flach KD, de Kort MAC, Maresca M, Teunissen H, Liu NQ, Lenstra TL, de Wit E.   +7 more
europepmc   +1 more source

Dual Functionality of miRNAs During HIV Infection: From Viral Genome Suppression to Immune Response Modulation. [PDF]

Epigenomes
Timofeeva AM, Aulova KS, Nevinsky GA.
europepmc   +1 more source

Single-cell immune profiling of blood and thrombus in cancer-associated thrombosis. [PDF]

iScience
Zhou L, Xia Y, Chen B, Lin X, Yang HC, Yu CW.   +5 more
europepmc   +1 more source

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Transcription Factors T-bet and GATA-3 Regulate Development of Airway Remodeling

American Journal of Respiratory and Critical Care Medicine, 2006
Abstract Rationale Airway remodeling is an important feature of chronic asthma that causes irreversible airflow obstruction. Although asthma is considered to be a Th2 disease, the role of T-bet and GATA-3, the key transcription factors for differentiation toward Th1 and Th2 cells, in the ...
Ahmed Hegab, Yuko Morishima, Satoru Takahashi   +2 more
exaly   +3 more sources

Salvia miltiorrhiza inhibits the expressions of transcription factor T-bet (T-bet) and tumor necrosis factor α (TNFα) in the experimental colitis in mice [PDF]

, 2015
Salvia miltiorrhiza (SM) is mainly used for the treatment of coronary heart disease in china and it also represses inflammation, but the mechanism is not well known. This study aimed to investigate the effects of SM powder for injection on the expressions of transcription factor T-bet (T-bet) and tumor necrosis factor α (TNFα) in the experimental ...
Dekui, Xu, Simeng, Wu, Hongbo, Yu, Changqing, Zheng, Dongmei, Liu, yan, Lin   +5 more
openaire   +3 more sources