Results 261 to 270 of about 14,321,563 (290)

T‐bet transcription factor in cardiovascular disease: Attenuation or inflammation factor?

Journal of Cellular Physiology, 2018
AbstractT‐bet is a major transcription factor increasing inflammatory responses in the immune system. Recently, it has been shown that this factor leads to inflammation in cardiovascular disease (CVD). In this study, we examine the dual role of T‐bet in inducing and suppressing inflammatory reactions as well as angiogenesis induction due to ...
Habib Haybar, Hadi Rezaeeyan, Mohammad Shahjahani, Reza Shirzad, Najmaldin Saki   +4 more
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Transcription Factor T-bet Orchestrates Lineage Development and Function in the Immune System

Trends in Immunology, 2017
T-bet was originally described as the key transcription factor defining type 1 T helper (Th) cells. However, it is now clear that it drives the orchestrated generation of effector and memory cells in multiple different lymphocyte lineages. In addition to Th1 cells, CD8 T cells, B cells and some innate lymphocyte populations require T-bet for their ...
Axel, Kallies, Kim L, Good-Jacobson
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T-bet, a T cell–associated transcription factor, is expressed in Hodgkin's lymphoma

Human Pathology, 2005
T-bet, a T-box transcription factor, is expressed in CD4+ T lymphocytes committed to Th1 T-cell development and may participate in immunoglobulin class switching in B lymphocytes. T-bet is also expressed in a subset of T-cell lymphomas, particularly those that express other markers of Th1 T cell differentiation, and in a subset of B-cell non-Hodgkin's ...
David M, Dorfman, Eun Sook, Hwang, Aliakbar, Shahsafaei, Laurie H, Glimcher   +3 more
openaire   +2 more sources

Research on the Roles of Transcription Factors T-bet and GATA-3 in Aplastic Anemia

Clinical Laboratory, 2014
Aplastic anemia (AA) is a type of bone marrow hematopoietic system disease. The immune mediated hematopoietic inhibition is recognized as the most common pathogenesis of AA. However, the roles of the T-bet/GATA-3-mediated cell immune disorder in aplastic anemia (AA) is still unknown.Experimental samples were obtained from 27 patients with AA, including
Haifei, Chen, Zhiyong, Luo, Hongshi, Shen, Chuanlu, Ren, Zhengyang, Li, Jieqing, Tang, Jing, Wang, Tianqin, Wu   +7 more
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Transcription Factor T-bet Attenuates the Development of Elastase-induced Emphysema in Mice

American Journal of Respiratory Cell and Molecular Biology, 2019
Abstract Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by peripheral airways inflammation and emphysema. Emerging evidence indicates a contribution of both innate and adaptive immune cells to the development of COPD.
Shigen, Hayashi, Yosuke, Matsuno, Yoshiya, Tsunoda, Hirofumi, Sakurai, Takumi, Kiwamoto, Yuko, Morishima, Yukio, Ishii, Keigyou, Yoh, Satoru, Takahashi, Nobuyuki, Hizawa   +9 more
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Transcription factor T-bet drives the pathogenesis of TH17-mediated neuroinflammation

The Journal of Immunology, 2018
Abstract Emergingdata demonstrate that exposure to pro-inflammatory cytokines IL-12 and IL-23 convertsnon-pathogenic IL-17A-producing CD4+ TH17 cells intopathogenic effectors, though the molecular mechanism remains undefined.
Tiffany Taylor Loo, Akane Shinoda, Vanja Lazarevic   +2 more
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The transcription factor T-bet promotes the pathogenesis of nonalcoholic fatty liver disease by upregulating intrahepatic inflammation

Biochemical and Biophysical Research Communications, 2023
To investigate the effect of the transcription factor T-bet on the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and the regulation of the intrahepatic immune microenvironment.Wild-type and T-bet knockout NASH mouse models were constructed. The effect of T-bet knockout on the pathogenesis of NAFLD was observed by histochemical staining.
Guangyong Sun, Yunxiong Wei, Jingjing Zhu, Shimeng Zheng, Zihan Zhang, Dong Zhang   +5 more
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Regulatory roles of transcription factors T-bet and Eomes in group 1 ILCs

International Immunopharmacology
T-bet and Eomes, both T-box transcription factors, have been extensively studied for their critical roles in the differentiation and functional maintenance of various immune cells. In this review, we provide a focused overview of their contributions to the transcriptional activation and differentiation, development, and terminal maturation of natural ...
Yue, Liao, Yanling, Zheng, Ruizhi, Zhang, Xiangming, Chen, Jijun, Huang, Jiamin, Liu, Yuyang, Zhao, Yu, Zheng, Xueyan, Zhang, Zhiyan, Gao, Xiaojing, Gao, Jin, Bu, Tieli, Peng, Xiaomin, Li, Erxia, Shen   +14 more
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The Transcription Factor, T-bet, Primes Intestine Transplantation Rejection and Is Associated With Disrupted Mucosal Homeostasis

Transplantation, 2015
The transcription factor, t-bet, promotes inflammatory polarization and intestinal homing of many inflammatory cells. In previous studies, the t-bet and granulysin genes were upregulated in peripheral blood before and after intestine transplantation (ITx) rejection, but not during rejection, possibly because of sequestration in allograft mucosa ...
Sarangarajan, Ranganathan, Chethan, Ashokkumar, Mylarappa, Ningappa, Lori, Schmitt, Brandon W, Higgs, Rakesh, Sindhi   +5 more
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The T-box transcription factor T-bet in immunity and autoimmunity.

Cellular & molecular immunology, 2006
The T-box transcription factor T-bet (Tbx21) has emerged as a key regulator of type 1-like immunity, playing critical roles in the establishment and/or maintenance of effector cell fates in T and B lymphocytes, as well as dendritic cells and natural killer cells. Several autoimmune diseases, especially those classically considered related to T helper 1
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