Results 271 to 280 of about 79,077 (284)
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Transcription Factor T-bet Attenuates the Development of Elastase-induced Emphysema in Mice
American Journal of Respiratory Cell and Molecular Biology, 2019Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by peripheral airways inflammation and emphysema. Emerging evidence indicates a contribution of both innate and adaptive immune cells to the development of COPD. Transcription factor T-bet modulates the function of immune cells and therefore might be involved in ...
Shigen, Hayashi +9 more
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T-bet, a T cell–associated transcription factor, is expressed in Hodgkin's lymphoma
Human Pathology, 2005T-bet, a T-box transcription factor, is expressed in CD4+ T lymphocytes committed to Th1 T-cell development and may participate in immunoglobulin class switching in B lymphocytes. T-bet is also expressed in a subset of T-cell lymphomas, particularly those that express other markers of Th1 T cell differentiation, and in a subset of B-cell non-Hodgkin's ...
David M, Dorfman +3 more
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Transcription Factor T-bet Orchestrates Lineage Development and Function in the Immune System
Trends in Immunology, 2017T-bet was originally described as the key transcription factor defining type 1 T helper (Th) cells. However, it is now clear that it drives the orchestrated generation of effector and memory cells in multiple different lymphocyte lineages. In addition to Th1 cells, CD8 T cells, B cells and some innate lymphocyte populations require T-bet for their ...
Axel, Kallies, Kim L, Good-Jacobson
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Regulatory roles of transcription factors T-bet and Eomes in group 1 ILCs
International ImmunopharmacologyT-bet and Eomes, both T-box transcription factors, have been extensively studied for their critical roles in the differentiation and functional maintenance of various immune cells. In this review, we provide a focused overview of their contributions to the transcriptional activation and differentiation, development, and terminal maturation of natural ...
Yue, Liao +14 more
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Pathobiology, 2006
Fibrosis, the pathological hallmark of scleroderma and related conditions, is due to sustained activation of tissue fibroblasts. Accumulating evidence implicates cytokine networks in initiating, and propagating or terminating fibroblast activation, and the specific cytokine phenotype dictates evolution of the fibrotic response toward either resolution ...
Gabriella, Lakos +3 more
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Fibrosis, the pathological hallmark of scleroderma and related conditions, is due to sustained activation of tissue fibroblasts. Accumulating evidence implicates cytokine networks in initiating, and propagating or terminating fibroblast activation, and the specific cytokine phenotype dictates evolution of the fibrotic response toward either resolution ...
Gabriella, Lakos +3 more
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Research on the Roles of Transcription Factors T-bet and GATA-3 in Aplastic Anemia
Clinical Laboratory, 2014Aplastic anemia (AA) is a type of bone marrow hematopoietic system disease. The immune mediated hematopoietic inhibition is recognized as the most common pathogenesis of AA. However, the roles of the T-bet/GATA-3-mediated cell immune disorder in aplastic anemia (AA) is still unknown.Experimental samples were obtained from 27 patients with AA, including
Haifei, Chen +7 more
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Transplantation, 2015
The transcription factor, t-bet, promotes inflammatory polarization and intestinal homing of many inflammatory cells. In previous studies, the t-bet and granulysin genes were upregulated in peripheral blood before and after intestine transplantation (ITx) rejection, but not during rejection, possibly because of sequestration in allograft mucosa ...
Sarangarajan, Ranganathan +5 more
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The transcription factor, t-bet, promotes inflammatory polarization and intestinal homing of many inflammatory cells. In previous studies, the t-bet and granulysin genes were upregulated in peripheral blood before and after intestine transplantation (ITx) rejection, but not during rejection, possibly because of sequestration in allograft mucosa ...
Sarangarajan, Ranganathan +5 more
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The T-box transcription factor T-bet in immunity and autoimmunity.
Cellular & molecular immunology, 2006The T-box transcription factor T-bet (Tbx21) has emerged as a key regulator of type 1-like immunity, playing critical roles in the establishment and/or maintenance of effector cell fates in T and B lymphocytes, as well as dendritic cells and natural killer cells. Several autoimmune diseases, especially those classically considered related to T helper 1
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Transcriptional factors F???3,?-Maf, GATA3 and T-bet in different variants of bronchial asthma
Molecular Pathology and Functional Genomics, 2017Predominance of Th-cells populations has been previously shown in patients with differtentvariants of bronchial asthma. To investigate cross-talk interactions between lymphocyte transcriptional factors Foxp3, c-Maf, GATA3 and T-bet we evaluated blood samples of 47 healthy volunteers and 82 patients with bronchial asthma. mRNA expression of Fохр3, с-Maf,
Anna Eremeeva +4 more
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EXPRESSION OF T-CELL TRANSCRIPTION FACTOR T-BET IS INCREASED IN COPD
B38. CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATHOGENESIS II, 2010Rainer Wiewrodt +7 more
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