Results 71 to 80 of about 79,077 (284)

Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis

Mechanisms of Development, 2002
A novel type of DNA-binding domain, the 'T-box' domain, characterizes an increasingly large family of transcription factors (Trends Genet. 15 (1999) 154). We have identified and characterized the expression pattern of a new member of the Tbr1 subfamily of T-box genes; this gene has been recently named T-bet/Tbx21 (Genomics 70 (2000) 41; Cell 17 (2000 ...
Andrea Faedo, Francesca Ficara, Michela Ghiani, Alessandro Aiuti, John LR Rubenstein, Alessandro Bulfone   +5 more
openaire   +4 more sources

Adenoid cystic carcinoma: emerging role of translocations and gene fusions. [PDF]

, 2016
Adenoid cystic carcinoma (ACC), the second most common salivary gland malignancy, is notorious for poor prognosis, which reflects the propensity of ACC to progress to clinically advanced metastatic disease.
Brait, Mariana, Ha, Patrick K, Izumchenko, Evgeny, Meir, Juliet, Sidransky, David, Wysocki, Piotr T   +5 more
core   +3 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

The activated glucocorticoid receptor inhibits the transcription factor T‐bet by direct protein‐protein interaction

The FASEB Journal, 2007
ABSTRACT Glucocorticoids (GCs) immunosuppression acts via regulation of several transcription factors (TF), including activating protein (AP)‐1, NF‐κB, and NFAT. GCs inhibit Th1 cytokines and promote a shift toward Th2 differentiation. Th1 phenotype depends on TF T‐bet.
Liberman, Ana Clara, Refojo, Damian, Druker, Jimena, Toscano, Marta Alicia, Rein, Theo, Holsboer, Florian, Arzt, Eduardo Simon   +6 more
openaire   +4 more sources

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma [PDF]

, 2013
Medulloblastoma is the most common malignant brain tumor of childhood, and represents a significant clinical challenge in pediatric oncology, since overall survival currently remains under 70%.
Althof, Kristina, Beckers, Anneleen, Eggert, Angelika, El-Hindy, Nicolai, Fleischhack, Gudrun, Henssen, Anton, Heukamp, Lukas, Odersky, Andrea, Schramm, Alexander, Schulte, Johannes H, Schäfers, Simon, Speleman, Franki, Sure, Ulrich, Thor, Theresa   +13 more
core   +4 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Salvia miltiorrhiza inhibits the expressions of transcription factor T-bet (T-bet) and tumor necrosis factor α (TNFα) in the experimental colitis in mice

AFRICAN JOURNAL OF BIOTECHNOLOGY, 2012
Salvia miltiorrhiza (SM) is mainly used for the treatment of coronary heart disease in china and it also represses inflammation, but the mechanism is not well known. This study aimed to investigate the effects of SM powder for injection on the expressions of transcription factor T-bet (T-bet) and tumor necrosis factor α (TNFα) in the experimental ...
Dekui, Xu, Simeng, Wu, Hongbo, Yu, Changqing, Zheng, Dongmei, Liu, yan, Lin   +5 more
openaire   +2 more sources

Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa [PDF]

Gut, 2004
In coeliac disease (CD) mucosa, the histological lesion is associated with marked infiltration of T helper cell type 1 (Th1) cells. However, the molecular mechanisms which regulate Th1 cell differentiation in CD mucosa are unknown.To analyse expression of transcription factors which control the Th1 cell commitment in CD.Duodenal mucosal samples were ...
MONTELEONE, IVAN, MONTELEONE, GIOVANNI, DEL VECCHIO BLANCO, GIOVANNA, Vavassori P., Cucchiara S., MacDonald T. T., PALLONE, FRANCESCO   +6 more
openaire   +3 more sources

Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity. [PDF]

, 2010
Peroxisome proliferator-activated receptors (PPARs; PPAR-alpha, PPAR-delta, and PPAR-gamma) comprise a family of nuclear receptors that sense fatty acid levels and translate this information into altered gene transcription.
Axtell, Robert, Bhat, Roopa, Chawla, Ajay, Dugas, Jason C, Dunn, Shannon E, Johnson, Amanda, Moshkova, Marina, Mukundan, Lata, Nguyen, Kim, Sobel, Raymond A, Steinman, Lawrence, Straus, Daniel S   +11 more
core   +3 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source