Results 91 to 100 of about 15,323,666 (293)

Chemotherapy induces myeloid-driven spatially confined T cell exhaustion in ovarian cancer

Anti-tumor immunity is crucial for high-grade serous ovarian cancer (HGSC) prognosis, yet its adaptation upon standard chemotherapy remains poorly understood.
Li, Yilin, Vähärautio, Anna, Färkkilä, Anniina, Chamchougia, Foteini, Falco, Matias M., Nagaraj, Ashwini, Liang, Zhihan, Hincapié-Otero, María, Launonen, Inga Maria, Virtanen, Anni, Nirmal, Ajit J., Hautaniemi, Sampsa, Junquera, Ada, Oikkonen, Jaana, Hynninen, Johanna, Erkan, Erdogan Pekcan, Szabo, Angela, Afenteva, Daria, Kahelin, Essi, Sorger, Peter K., Niemiec, Iga, Vallius, Tuulia, Perez-Villatoro, Fernando, Micoli, Giulia, Salko, Matilda, Haltia, Ulla Maija, Launonen, Inga-Maria, Haltia, Ulla-Maija   +27 more
core   +1 more source

Biomimetic Hybrid‐Membrane Nanoreactor for Deep‐Seated Photodynamic Immunotherapy of Hepatocellular Carcinoma via Dual Catalysis‐Enhanced ROS Amplification and cGAS‐STING Activation

Advanced Functional Materials, EarlyView.
UCNP@MnOx‐Hyp@HRM (UMHM) enables tumor targeting and accumulation. Under 808 nm NIR irradiation, PDT/CDT synergistically triggers ICD and cGAS–STING immunity for deep hepatocellular carcinoma therapy. ABSTRACT Photodynamic therapy (PDT) is promising against hepatocellular carcinoma (HCC).
Wen Li, Jianzhang Luo, Pei Lu, Dongqing Liu, Huijun Yi, Xiaoyuan Yi, Bixia Chi, Wen Chen, Qingyu Zeng, Feifei He, Liyan Wang   +10 more
wiley   +1 more source

Bio-functional hydrogel coated membranes to decrease T-cell exhaustion in manufacturing of CAR T-cells

Frontiers in Immunology
IntroductionCell therapies have revolutionized cancer treatment, with chimeric antigen receptor (CAR) T-cell therapies at the forefront for the treatment of hematological cancers.
Aida López Ruiz, Eric Slaughter, Kartik Bomb, Samantha L. Swedzinski, Paige J. LeValley, Zaining Yun, Jacob McCoskey, Kara Levine, Jonathan Steen, Joseph Almasian, Aparajita Chatterjee, Christina Carbrello, Dustin S. Chang, Hubaida Fuseini, Yama A. Abassi, Abraham M. Lenhoff, Catherine A. Fromen, April M. Kloxin, April M. Kloxin   +18 more
doaj   +1 more source

Cystine Restriction Alleviates T Cell Exhaustion and Enhances CAR-T Cell Potency

While chimeric antigen receptor (CAR) T cell therapy has demonstrated significant efficacy in treating hematological malignancies, its application in solid tumors remains challenging.
Xin Wang, Pengyuan Wang, Shanwen Chen, Xiaoxue Pan, Yucun Liu, Yuhang Yin, Jing Zhu, Jichang Li, Haopeng Hong   +8 more
core   +1 more source

Anti‐Inflammatory and Neuroactive Effects of Polymer‐Coated Iron Oxide Nanoparticles Functionalized With Interleukin 4 for Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez, Paloma Lozano‐Picazo, María de Lamo‐Atencia, Andrea Ferreras, Esther Benayas‐Martín, Elena Fernández‐López, Marina Sánchez‐Petidier, Verónica Barranco‐Maresca, Víctor Caz, Anne des Rieux, Juliana M. Rosa, María del Puerto Morales, María C. Serrano   +12 more
wiley   +1 more source

Revitalizing T cells: breakthroughs and challenges in overcoming T cell exhaustion

Signal Transduction and Targeted Therapy
T cell exhaustion is a prevalent phenomenon in chronic infections and tumor microenvironments, severely compromising the effectiveness of antitumor and antiviral immunity.
Yiran Wu, Yuchen Wu, Zhengyu Gao, Weixing Yu, Long Zhang, Fangfang Zhou   +5 more
doaj   +1 more source

Topically Delivered Treg‐Attracting Microparticle‐Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia

Advanced Healthcare Materials, EarlyView.
CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli, Alexis T. Reese, Jordan J. P. Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J. Baust, Brenda McMahon, Steven R. Little, Hēth R. Turnquist   +8 more
wiley   +1 more source

T Cell Exhaustion in Glioblastoma

, 2020
Glioblastoma (GBM) is the most common primary malignant brain tumor. Despite standard of care treatment GBM remains universally lethal, demonstrating a significant need for newer treatment strategies such as immunotherapy. Immune checkpoint blockade is a
Woroniecka, Karolina
core  

Reversing the effects of immune cell exhaustion

, 2022
During exposure to infection, CD8 T-cells (naive T-cells) differentiate into effector and memory immune cells, creating a more efficient immune system. With chronic infection, many T-cells begin to enter a state of dysfunction or exhaustion, which often ...
Kodre, Reva
core   +1 more source

Hemocompatible Glycogen‐Tissue Plasminogen Activator Complexes for Enhanced Blood Clot Dissolution

Advanced Healthcare Materials, EarlyView.
Glycogen–heparin‐cRGD nanoparticles enable targeted delivery of tissue plasminogen activator (tPA) to thrombi through activated platelet recognition. The hemocompatible hybrids minimize interactions with blood and immune cells while retaining enzymatic biodegradability.
Nadiia Davydiuk, Vaidehi Londhe, Susanne Boye, Martin Müller, Carsten Werner, Manfred F. Maitz, Quinn A. Besford   +6 more
wiley   +1 more source