Results 1 to 10 of about 2,701,466 (355)
T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignancies
Nature Communications, 2022 Healthy T cells are polyclonal, while malignant T cells are developing via clonal expansion. Here authors show that T cell tumours could be eradicated by chimeric antigen receptor T cells targeting the T cell receptor (TCR) β-chain that is specific to ...
Fanlin Li +17 more
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Protocol for assessing T cell receptor-mediated human T cell cytotoxicity
STAR ProtocolsSummary: Measuring the cytotoxicity of human T cells is a valuable but challenging task. We present a protocol for assessing the ability of polyclonal human T cells to kill target cells upon T cell receptor (TCR) triggering.
Kathryne E. Marks +3 more
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TRain: T-cell receptor automated immunoinformatics [PDF]
BMC BioinformaticsBackground The scarcity of available structural data makes characterizing the binding of T-cell receptors (TCRs) to peptide-Major Histocompatibility Complexes (pMHCs) very challenging.
Austin Seamann +5 more
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Frontiers in Immunology, 2021 The inhibition of anabolic pathways, such as aerobic glycolysis, is a metabolic cornerstone of memory T cell differentiation and function. However, the signals that hamper these anabolic pathways are not completely known.
Raquel Blanco +8 more
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Journal of Veterinary Internal Medicine, 2021 Background T cell clonality assays in veterinary medicine currently target only the T cell receptor gamma (TRG) locus. Existing assays have suboptimal sensitivity because of insufficient primer coverage of all possible rearrangements.
Araya Radtanakatikanon +3 more
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Promising New Tools for Targeting p53 Mutant Cancers: Humoral and Cell-Based Immunotherapies
Frontiers in Immunology, 2021 Transcription factor and oncosuppressor protein p53 is considered as one of the most promising molecular targets that remains a high-hanging fruit in cancer therapy.
Vitaly Chasov +9 more
doaj +1 more source
T cell receptor sequence clustering and antigen specificity
Computational and Structural Biotechnology Journal, 2020 There has been increasing interest in the role of T cells and their involvement in cancer, autoimmune and infectious diseases. However, the nature of T cell receptor (TCR) epitope recognition at a repertoire level is not yet fully understood.
Milena Vujovic +7 more
doaj +1 more source
TCR-NK Cells: A Novel Source for Adoptive Immunotherapy of Cancer
Turkish Journal of Hematology, 2023 Antigen-specific retargeting of cytotoxic lymphocytes against tumorassociated antigens has thus far remained largely dependent on chimeric antigen receptors (CARs) that can be constructed by the fusion of an extracellular targeting domain (classically a ...
Zeynep Sena Karahan +2 more
doaj +1 more source
Rac activation by the T-cell receptor inhibits T cell migration. [PDF]
PLoS ONE, 2010 T cell migration is essential for immune responses and inflammation. Activation of the T-cell receptor (TCR) triggers a migration stop signal to facilitate interaction with antigen-presenting cells and cell retention at inflammatory sites, but the ...
Eva Cernuda-Morollón +4 more
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Robust T cell activation requires an eIF3-driven burst in T cell receptor translation
eLife, 2021 Activation of T cells requires a rapid surge in cellular protein synthesis. However, the role of translation initiation in the early induction of specific genes remains unclear. Here, we show human translation initiation factor eIF3 interacts with select
Dasmanthie De Silva +10 more
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