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T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignancies
Nature Communications, 2022 Healthy T cells are polyclonal, while malignant T cells are developing via clonal expansion. Here authors show that T cell tumours could be eradicated by chimeric antigen receptor T cells targeting the T cell receptor (TCR) β-chain that is specific to ...
Fanlin Li +17 more
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Journal of Veterinary Internal Medicine, 2021 Background T cell clonality assays in veterinary medicine currently target only the T cell receptor gamma (TRG) locus. Existing assays have suboptimal sensitivity because of insufficient primer coverage of all possible rearrangements.
Araya Radtanakatikanon +3 more
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Frontiers in Immunology, 2021 The inhibition of anabolic pathways, such as aerobic glycolysis, is a metabolic cornerstone of memory T cell differentiation and function. However, the signals that hamper these anabolic pathways are not completely known.
Raquel Blanco +8 more
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Promising New Tools for Targeting p53 Mutant Cancers: Humoral and Cell-Based Immunotherapies
Frontiers in Immunology, 2021 Transcription factor and oncosuppressor protein p53 is considered as one of the most promising molecular targets that remains a high-hanging fruit in cancer therapy.
Vitaly Chasov +9 more
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T cell receptor sequence clustering and antigen specificity
Computational and Structural Biotechnology Journal, 2020 There has been increasing interest in the role of T cells and their involvement in cancer, autoimmune and infectious diseases. However, the nature of T cell receptor (TCR) epitope recognition at a repertoire level is not yet fully understood.
Milena Vujovic +7 more
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TCR-NK Cells: A Novel Source for Adoptive Immunotherapy of Cancer
Turkish Journal of Hematology, 2023 Antigen-specific retargeting of cytotoxic lymphocytes against tumorassociated antigens has thus far remained largely dependent on chimeric antigen receptors (CARs) that can be constructed by the fusion of an extracellular targeting domain (classically a ...
Zeynep Sena Karahan +2 more
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Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine. [PDF]
, 2018 Whether γδ T cells inhibit or enhance the Foxp3 T cell response depends upon their activation status. The critical enhancing effector in the supernatant is adenosine.
Born, Willi K +6 more
core +6 more sources
Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness. [PDF]
, 2017 Zap70 plays a critical role in normal T cell development and T cell function. However, little is known about how perturbation of allosteric autoinhibitory mechanisms in Zap70 impacts T cell biology.
Chen, Yiling +4 more
core +2 more sources
Intrathymic expression of Flt3 ligand enhances thymic recovery after irradiation [PDF]
, 2008 Hematopoietic stem cell transplantation (HSCT) requires conditioning treatments such as irradiation, which leads to a severely delayed recovery of T cell immunity and constitutes a major complication of this therapy.
Kenins, L. +4 more
core +2 more sources
Robust T cell activation requires an eIF3-driven burst in T cell receptor translation
eLife, 2021 Activation of T cells requires a rapid surge in cellular protein synthesis. However, the role of translation initiation in the early induction of specific genes remains unclear. Here, we show human translation initiation factor eIF3 interacts with select
Dasmanthie De Silva +10 more
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