Results 1 to 10 of about 4,863,616 (332)

Protocol for assessing T cell receptor-mediated human T cell cytotoxicity [PDF]

STAR Protocols
Summary: Measuring the cytotoxicity of human T cells is a valuable but challenging task. We present a protocol for assessing the ability of polyclonal human T cells to kill target cells upon T cell receptor (TCR) triggering.
Kathryne E. Marks, Ifeoluwakiisi Adejoorin, John Sowerby, Deepak A. Rao   +3 more
doaj   +2 more sources

Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen [PDF]

Nature Communications
T cell receptor-engineered T cells (TCR-T) could be advantageous in glioblastoma by allowing safe and ubiquitous targeting of the glioblastoma-derived peptidome.
Yu-Chan Chih, Amelie C. Dietsch, Philipp Koopmann, Xiujian Ma, Dennis A. Agardy, Binghao Zhao, Alice De Roia, Alexandros Kourtesakis, Michael Kilian, Christopher Krämer, Abigail K. Suwala, Miriam Stenzinger, Halvard Boenig, Agnieszka Blum, Victor Murcia Pienkowski, Kuralay Aman, Jonas P. Becker, Henrike Feldmann, Theresa Bunse, Richard Harbottle, Angelika B. Riemer, Hai-Kun Liu, Nima Etminan, Felix Sahm, Miriam Ratliff, Wolfgang Wick, Michael Platten, Edward W. Green, Lukas Bunse   +28 more
doaj   +2 more sources

TRain: T-cell receptor automated immunoinformatics [PDF]

BMC Bioinformatics
Background The scarcity of available structural data makes characterizing the binding of T-cell receptors (TCRs) to peptide-Major Histocompatibility Complexes (pMHCs) very challenging.
Austin Seamann, Maia Bennett-Boehm, Ryan Ehrlich, Anna Gil, Liisa Selin, Dario Ghersi   +5 more
doaj   +2 more sources

The T cell receptor sequence influences the likelihood of T cell memory formation [PDF]

Cell Reports
Summary: The amino acid sequence of the T cell receptor (TCR) varies between T cells of an individual’s immune system. Particular TCR residues nearly guarantee mucosal-associated invariant T (MAIT) and natural killer T (NKT) cell transcriptional fates ...
Kaitlyn A. Lagattuta, Ayano C. Kohlgruber, Nouran S. Abdelfattah, Aparna Nathan, Laurie Rumker, Michael E. Birnbaum, Stephen J. Elledge, Soumya Raychaudhuri   +7 more
doaj   +2 more sources

Genesis of the alpha beta T-cell receptor [PDF]

PLoS Comp. Biol. 15(3): e1006874 (2019), 2018
The T-cell (TCR) repertoire relies on the diversity of receptors composed of two chains, called $\alpha$ and $\beta$, to recognize pathogens. Using results of high throughput sequencing and computational chain-pairing experiments of human TCR repertoires, we quantitively characterize the $\alpha\beta$ generation process.
Thierry Mora, Thomas Dupic, Thomas Dupic, Quentin Marcou, Aleksandra M. Walczak   +4 more
arxiv   +11 more sources

T-cell receptor and B-cell receptor repertoires profiling in pleural tuberculosis [PDF]

Frontiers in Immunology
BackgroundTuberculosis (TB) is a leading cause of death worldwide from a single infectious agent. In China the most common extra-pulmonary TB (EPTB) is pleural tuberculosis (PLTB).
Fengjiao Du, Yunyun Deng, Ling Deng, Boping Du, Aiying Xing, Hong Tao, Hua Li, Li Xie, Xinyong Zhang, Tao Sun, Tao Sun, Hao Li, Hao Li   +12 more
doaj   +2 more sources

T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignancies

Nature Communications, 2022
Healthy T cells are polyclonal, while malignant T cells are developing via clonal expansion. Here authors show that T cell tumours could be eradicated by chimeric antigen receptor T cells targeting the T cell receptor (TCR) β-chain that is specific to ...
Fanlin Li, Huihui Zhang, Wanting Wang, Puyuan Yang, Yue Huang, Junshi Zhang, Yaping Yan, Yuan Wang, Xizhong Ding, Jie Liang, Xinyue Qi, Min Li, Ping Han, Xiaoqing Zhang, Xin Wang, Jiang Cao, Yang-Xin Fu, Xuanming Yang   +17 more
doaj   +1 more source

The Chemokine Receptor CCR5 Links Memory CD4+ T Cell Metabolism to T Cell Antigen Receptor Nanoclustering

Frontiers in Immunology, 2021
The inhibition of anabolic pathways, such as aerobic glycolysis, is a metabolic cornerstone of memory T cell differentiation and function. However, the signals that hamper these anabolic pathways are not completely known.
Raquel Blanco, Marta Gómez de Cedrón, Laura Gámez-Reche, Laura Gámez-Reche, Ana Martín-Leal, Alicia González-Martín, Rosa A. Lacalle, Ana Ramírez de Molina, Santos Mañes   +8 more
doaj   +1 more source

T cell receptor (TCR) signaling in health and disease

Signal Transduction and Targeted Therapy, 2021
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell ...
K. Shah, A. Al-haidari, Jianmin Sun, Julhash U. Kazi   +3 more
semanticscholar   +1 more source

Novel clonality assays for T cell lymphoma in cats targeting the T cell receptor beta, T cell receptor delta, and T cell receptor gamma loci

Journal of Veterinary Internal Medicine, 2021
Background T cell clonality assays in veterinary medicine currently target only the T cell receptor gamma (TRG) locus. Existing assays have suboptimal sensitivity because of insufficient primer coverage of all possible rearrangements.
Araya Radtanakatikanon, Peter F. Moore, Stefan M. Keller, William Vernau   +3 more
doaj   +1 more source