Results 31 to 40 of about 4,863,715 (431)

Statistical inference of the generation probability of T-cell receptors from sequence repertoires [PDF]

PNAS October 2, 2012 vol. 109 no. 40 16161-16166, 2012
Stochastic rearrangement of germline DNA by VDJ recombination is at the origin of immune system diversity. This process is implemented via a series of stochastic molecular events involving gene choices and random nucleotide insertions between, and deletions from, genes.
arxiv   +1 more source

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

Science, 2016
Immunotherapeutic PD-1–targeted therapies require CD28 to promote cancer cell killing. CD28 is a critical target for PD-1 blockade PD-1–targeted therapies have been a breakthrough for treating certain tumors and can rejuvenate T cells to unleash the ...
E. Hui, Jeanne Cheung, Jing Zhu, Xiaolei Su, Marcus J. Taylor, H. Wallweber, Dibyendu K. Sasmal, Jun Huang, J. Kim, I. Mellman, R. Vale   +10 more
semanticscholar   +1 more source

Force generation upon T cell receptor engagement. [PDF]

PLoS ONE, 2011
T cells are major players of adaptive immune response in mammals. Recognition of an antigenic peptide in association with the major histocompatibility complex at the surface of an antigen presenting cell (APC) is a specific and sensitive process whose ...
Julien Husson, Karine Chemin, Armelle Bohineust, Claire Hivroz, Nelly Henry   +4 more
doaj   +1 more source

Transgenic expression of the Ly49A natural killer cell receptor confers class I major histocompatibility complex (MHC)-specific inhibition and prevents bone marrow allograft rejection. [PDF]

, 1996
Natural killer (NK) cells and some T cells are endowed with receptors specific for class I major histocompatibility complex (MHC) molecules that can inhibit cellular effector functions.
Cado, D, Held, W, RAULET, David H.
core   +1 more source

The human T-cell receptor

Journal of Clinical Immunology, 1985
Recent studies using cloned antigen-specific T lymphocytes and monoclonal antibodies directed at their various surface glycoprotein components have led to the identification of the human T-cell antigen receptor as a surface complex comprised of a clonotypic 90-kD Ti heterodimer and the invariant 20- and 25-kD T3 molecules.
Acuto, O, Fabbi, M, Bensussan, A, Milanese, C, Campen, T, Royer, H, Reinherz, E   +6 more
openaire   +4 more sources

Cell surface receptors

Current Opinion in Structural Biology, 2000
During the past year, the database of ligand-receptor complexes has essentially doubled. These new results have immeasurably extended and expanded our view of cell surface receptor structure and function. The flood of data has revealed new models for receptor cross-linking, demonstrating the potential stringency of the extracellular requirements for ...
Deller, M, Yvonne Jones, E
openaire   +4 more sources

Modeling interaction of Glioma cells and CAR T-cells considering multiple CAR T-cells bindings [PDF]

arXiv, 2022
Chimeric antigen receptor (CAR) T-cell based immunotherapy has shown its potential in treating blood cancers, and its application to solid tumors is currently being extensively investigated. For glioma brain tumors, various CAR T-cell targets include IL13Ra2, EGFRvIII, HER2, EphA2, GD2, B7-H3, and chlorotoxin.
arxiv  

Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires [PDF]

PLoS Comput Biol 13(7): e1005572 (2017), 2016
The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequence rare. Yet unrelated individuals do share receptors, which together constitute a "public" repertoire of abundant clonotypes.
arxiv   +1 more source

Early Investigations and Recent Advances in Intraperitoneal Immunotherapy for Peritoneal Metastasis. [PDF]

, 2018
Peritoneal metastasis (PM) is an advanced stage malignancy largely refractory to modern therapy. Intraperitoneal (IP) immunotherapy offers a novel approach for the control of regional disease of the peritoneal cavity by breaking immune tolerance.
Bowne, Wilbur B., Katz, Steven C., Khalili, Marian, Morano, William F., Richard, Scott D., Thadi, Anusha   +5 more
core   +2 more sources

Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor-modified T-cell therapy.

Blood, 2017
Lymphodepletion chemotherapy followed by infusion of CD19-specific chimeric antigen receptor-modified (CAR) T cells has produced impressive antitumor responses in patients with refractory CD19+ B-cell malignancies but is often associated with cytokine ...
K. Hay, K. Hay, L. Hanafi, Daniel H. Li, J. Gust, W. Liles, M. Wurfel, José A López, Junmei Chen, D. Chung, Susanna Harju-Baker, S. Cherian, Xueyan Chen, S. Riddell, S. Riddell, D. Maloney, D. Maloney, C. Turtle, C. Turtle   +18 more
semanticscholar   +1 more source