Results 61 to 70 of about 4,863,715 (431)

VDJdb: a curated database of T-cell receptor sequences with known antigen specificity

Nucleic Acids Res., 2017
The ability to decode antigen specificities encapsulated in the sequences of rearranged T-cell receptor (TCR) genes is critical for our understanding of the adaptive immune system and promises significant advances in the field of translational medicine ...
M. Shugay, D. V. Bagaev, I. Zvyagin, Renske M. A. Vroomans, J. Crawford, G. Dolton, E. Komech, A. L. Sycheva, Anna E. Koneva, E. Egorov, E. Egorov, A. Eliseev, E. Dyk, P. Dash, Meriem Attaf, C. Rius, K. Ladell, J. McLaren, Katherine K Matthews, E. B. Clemens, D. Douek, F. Luciani, D. Baarle, K. Kedzierska, C. Keşmir, P. Thomas, David A Price, D. Price, A. Sewell, D. Chudakov   +29 more
semanticscholar   +1 more source

T cell receptor sequence clustering and antigen specificity

Computational and Structural Biotechnology Journal, 2020
There has been increasing interest in the role of T cells and their involvement in cancer, autoimmune and infectious diseases. However, the nature of T cell receptor (TCR) epitope recognition at a repertoire level is not yet fully understood.
Milena Vujovic, Kristine Fredlund Degn, Frederikke Isa Marin, Anna-Lisa Schaap-Johansen, Benny Chain, Thomas Lars Andresen, Joseph Kaplinsky, Paolo Marcatili   +7 more
doaj  

Crystalline silica activates the T-cell and the B-cell antigen receptor complexes and induces T-cell and B-cell proliferation

Autoimmunity, 2019
Silicosis is an occupational fibrotic lung disease, which is associated with an increased incidence of autoimmune diseases. The effect of crystalline silica on the immune system is thought to be mediated by the antigen presenting cells.
Theodoros Eleftheriadis, Georgios Pissas, Sotirios Zarogiannis, Vassilios Liakopoulos, Ioannis Stefanidis   +4 more
doaj   +1 more source

Core Fucosylation of the T Cell Receptor Is Required for T Cell Activation

Frontiers in Immunology, 2018
CD4+ T cell activation promotes the pathogenic process of systemic lupus erythematosus (SLE). T cell receptor (TCR) complex are highly core fucosylated glycoproteins, which play important roles in T cell activation.
Wei Liang, Shanshan Mao, Shijie Sun, Ming Li, Zhi Li, Rui Yu, Tonghui Ma, Jianguo Gu, Jianing Zhang, Naoyuki Taniguchi, Wenzhe Li   +10 more
doaj   +1 more source

An introduction to chimeric antigen receptor (CAR) T‐cell immunotherapy for human cancer

American journal of hematology/oncology, 2019
Chimeric antigen receptor (CAR) T‐cell therapy represents a major advancement in personalized cancer treatment. In this strategy, a patient's own T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen.
Steven Feins, Weimin Kong, E. Williams, M. Milone, J. Fraietta   +4 more
semanticscholar   +1 more source

MAVS Is essential for primary CD4 + T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection [PDF]

, 2017
The use of pathogen recognition receptor (PRR) agonists and the molecular mechanisms involved have been the major focus of research in individual vaccine development.
Barrett, Alan D, Diamond, Michael S, Fang, Rong, Gale, Michael, Jr, Lazear, Helen M, Li, Li, Luo, Huanle, Paessler, Slobodan, Peng, Bi-Hung, Wang, Tian, Winkelmann, Evandro, Xie, Guorui   +11 more
core   +3 more sources

The discriminatory power of the T cell receptor [PDF]

eLife, 2020
AbstractT cells use their T-cell receptors (TCRs) to discriminate between lower-affinity self and higher affinity non-self pMHC antigens. Although the discriminatory power of the TCR is widely believed to be near-perfect, technical difficulties have hampered efforts to precisely quantify it.
Omer Dushek, Mikhail A Kutuzov, Enas Abu Shah, Michael L. Dustin, Simon J. Davis, Johannes Pettmann, Anna Huhn, P. Anton van der Merwe, Daniel B. Wilson, Daniel B. Wilson   +9 more
openaire   +6 more sources

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Fit αβ T-cell receptor suppresses leukemogenesis of Pten-deficient thymocytes

Haematologica, 2018
Signaling through the αβT cell receptor (TCR) is a crucial determinant of T-cell fate and can induce two opposite outcomes during thymocyte development: cell death or survival and differentiation.
Stéphanie Gon, Marie Loosveld, Thomas Crouzet, Delphine Potier, Mélanie Bonnet, Stéphanie O. Morin, Gérard Michel, Norbert Vey, Jacques A. Nunès, Bernard Malissen, Romain Roncagalli, Bertrand Nadel, Dominique Payet-Bornet   +12 more
doaj   +1 more source

Generalizable design parameters for soluble T cell receptor-based T cell engagers

Journal for ImmunoTherapy of Cancer, 2022
While most biological and cellular immunotherapies recognize extracellular targets, T cell receptor (TCR) therapeutics are unique in their ability to recognize the much larger pool of intracellular antigens found on virus-infected or cancerous cells ...
Flora Huang, Arlene Sereno, Karen J Froning, Stephen J Demarest   +3 more
doaj   +1 more source