Results 61 to 70 of about 2,529,459 (356)

Characterization of avian natural killer cells and their intracellular CD3 protein complex [PDF]

, 1994
Natural killer (NK) cell activity appears to be conserved throughout vertebrate development but NK cells have only been well characterized in mammals. Candidate NK cells have been identified in the chicken as cytoplasmic CD3+ and surface T cell receptor (
Anderson, Anderson, Bernot, Bucy, Bucy, Chan, Char, Chen, Chen, Chen, Chen, Chomczynski, Ciccone, Cihak, Coltey, Cooper, Dennert, Guillemot, Göbel, Hori, Hála, Laemmli, Lahti, Lanier, Lanier, Lillehoj, Mingari, Moretta, Myers, Nowak, Ortaldo, Phillips, Phillips, Poggi, Ratcliffe, Ritz, Rodewald, Schauenstein, Schnetzler, Sharma, Sowder, Spurr, Suzuki, Terry, Tjoelker, Trinchieri, Voss, Vujanovic, Wilson   +48 more
core   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Elementary steps in T cell receptor triggering

Frontiers in Immunology, 2012
The mechanism by which antigen binding to the T cell antigen receptor (TCR) generates intracellular signaling, a process termed TCR triggering, is incompletely understood.
Omer eDushek, Omer eDushek
doaj   +1 more source

CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. [PDF]

, 1992
Engagement of the CD3/T cell antigen receptor complex on small, resting T cells is insufficient to trigger cell-mediated cytotoxicity or to induce a proliferative response.
Azuma, M, Buck, D, Cayabyab, M, Lanier, LL, Phillips, JH   +4 more
core   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

CCDC134 facilitates T cell activation through the regulation of early T cell receptor signaling

Frontiers in Immunology, 2023
Modulation of surface T cell antigen receptor (TCR) expression is crucial for proper T cell development and maintenance of mature T cell function at steady state and upon stimulation.
Tianzhuo Zhang, Qianwen Shi, Huining Gu, Biaoyi Yu, Sha Yin, Sha Yin, Qing Ge, Xiaoning Mo, Xiaofeng Liu, Jing Huang   +9 more
doaj   +1 more source

New simplified molecular design for functional T cell receptor [PDF]

, 1993
We have produced a chimeric single-chain T cell receptor (TcR) that combines the specific antibody recognition function and TcR/CD3 signaling properties within the same polypeptide chain.
Clevers, Cosson, Eshhar, Frank, Gillis, Gunning, Hackett, Huston, Ihle, Irving, Lanzavecchia, Leo, Mosmann, Oi, Romeo, Sterz, Tada, Traunecker, Walker, Wegener, Weissman, Weissman, White, Zamoyska   +23 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Primary cutaneous aggressive epidermotropic cytotoxic T-cell lymphomas: reappraisal of a provisional entity in the 2016 WHO classification of cutaneous lymphomas. [PDF]

, 2017
Primary cutaneous CD8-positive aggressive epidermotropic T-cell lymphoma is a rare and poorly characterized variant of cutaneous lymphoma still considered a provisional entity in the latest 2016 World Health Organization Classification of Cutaneous ...
Duvic, Madeleine, Girardi, Michael, Guitart, Joan, Ivan, Doina S, Junkins-Hopkins, Jacqueline, Kim, Ellen, Kim, Jinah, Kim, Youn H, Martinez-Escala, M Estela, Olsen, Elise A, Pincus, Laura B, Pulitzer, Melissa P, Rook, Alain H, Sable, Kimberly A, Samimi, Sara S, Selim, M Angelica, Subtil, Antonio, Tetzlaff, Michael T, Virmani, Pooja, Wood, Gary S   +19 more
core   +1 more source

Regulation of T Cell Apoptosis via T Cell Receptors and Steroid Receptors [PDF]

STEM CELLS, 1996
Less than 5% of immature CD4/CD8 double-positive (DP) thymocytes are positively selected to survive and differentiate into single-positive CD4 and CD8 T cells, while self-reactive DP thymocytes undergo apoptosis (negative selection). Both positive and negative selection events are active processes that involve signaling through the T cell receptors ...
Takeshi Kuwata, Makoto Iwata, Yoshiharu Ohoka, Akiko Asada   +3 more
openaire   +3 more sources