Results 81 to 90 of about 2,529,459 (356)
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Chimeric Antigen Receptor-T Cell Therapy
HemaSphere, 2018 . Chimeric antigen receptor (CAR)-T cell therapy is a new class of cellular immunotherapies that involves ex vivo genetic modification of T cells to incorporate an engineered CAR.
Jochen Buechner +4 more
doaj +1 more source
Journal of the Egyptian National Cancer Institute, 2023 Background T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy with few accepted prognostic factors that limit the efficiency of therapy.
Mona S. El Ashry +4 more
doaj +1 more source
Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia [PDF]
, 2004 We previously demonstrated prolonged, profound CD4+ T-lymphopenia in rheumatoid arthritis (RA) patients following lymphocyte-depleting therapy. Poor reconstitution could result either from reduced de novo T-cell production through the thymus or from poor
Bingham, S.J. +26 more
core +2 more sources
Crossreactivity of the T-cell receptor [PDF]
Immunology Today, 1998 In this issue of Immunology Today, Don Mason argues that T cells should be highly degenerate in order to allow an immune response against any T-cell epitope. Because the number of possible epitopes is indeed much larger than the number of T-cell clonotypes in any immune system, we fully agree that each clonotype should recognize many epitopes ...
Borghans, J.A.M., Boer, R.J. de
openaire +3 more sources
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
T-cell abnormalities are present at high frequencies in patients with hypereosinophilic syndrome
Haematologica, 2009 Background A T-cell clone, thought to be the source of eosinophilopoietic cytokines, identified by clonal rearrangement of the T-cell receptor and by the presence of aberrant T-cell immunophenotype in peripheral blood defines lymphocytic variant of ...
Grzegorz Helbig +4 more
doaj +1 more source
A new approach to understanding T cell development: the isolation and characterization of immature CD4-, CD8-, CD3- T cell cDNAs by subtraction cloning [PDF]
, 1992 During T cell development in the mammalian thymus, immature T cells are observed that lack the cell surface markers CD4, CD8, and CD3. A subtracted cDNA library was constructed to isolate cDNAs that are specific for these immature T cells.
Gese, Elaine, Hood, Leroy, Orr, Sally L.
core
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Molecular Determinants of Target Cell Recognition by Human γδ T Cells
Frontiers in Immunology, 2018 The unique capabilities of gamma-delta (γδ) T cells to recognize cells under stressed conditions, particularly infected or transformed cells, and killing them or regulating the immune response against them, paved the way to the development of promising ...
André E. Simões +3 more
doaj +1 more source