Results 91 to 100 of about 96,959 (285)

Flexibility in T‐cell receptor ligand repertoires depends on MHC and T‐cell receptor clonotype [PDF]

Immunology, 1997
SUMMARYT‐cell receptors (TCR) recognize peptides complexed to self‐major histocompatibility complex (MHC) molecules. Recognition of peptide/MHC ligands by the TCR is highly peptide specific. However, certain TCRs can also recognize sequence‐related and ‐unrelated (‘mimicry’) epitopes presented by homologous MHC molecules.
A, Geluk, K E, van Meijgaarden, T H, Ottenhoff   +2 more
openaire   +2 more sources

Characterization of T-cell receptor loci and expressed repertoire reveals a capacity for robust T-cell response in Atlantic cod (Gadus morhua)

Scientific Reports
The Atlantic cod presents a peculiar case in fish immunology, due to the loss of MHCII and CD4 genes. Despite the absent antibody response to T cell-dependent antigens, it is a prolific species.
Ádám Györkei, Finn-Eirik Johansen, Shuo-Wang Qiao   +2 more
doaj   +1 more source

Next-Generation Sequencing Analysis of the Human TCRγδ+ T-Cell Repertoire Reveals Shifts in Vγ- and Vδ-Usage in Memory Populations upon Aging

Frontiers in Immunology, 2018
Immunological aging remodels the immune system at several levels. This has been documented in particular for the T-cell receptor (TCR)αβ+ T-cell compartment, showing reduced naive T-cell outputs and an accumulation of terminally differentiated clonally ...
Martine J. Kallemeijn, François G. Kavelaars, Michèle Y. van der Klift, Ingrid L. M. Wolvers-Tettero, Peter J. M. Valk, Jacques J. M. van Dongen, Anton W. Langerak   +6 more
doaj   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Regulatory T‐cells: receptors, repertoires and roles in disease [PDF]

Immunology, 2018
SummaryIn the 20‐or‐so years that immunologists have spent describing the mechanisms and functions of regulatory T‐cells, a very great deal has been learnt: a T‐cell subset once described for the generic ability to harness autoimmunity in vivo or diminish T‐cell proliferation in vitro is now appreciated to act on a plethora of cellular pathways using a
openaire   +2 more sources

Multivariate analysis using high definition flow cytometry reveals distinct T cell repertoires between the foetal-maternal interface and the peripheral blood

Frontiers in Immunology, 2014
The human T-cell compartment is a complex system and while some information is known on repertoire composition and dynamics in the peripheral blood, little is known on repertoire composition at different anatomical sites.
Michelle eNeller, Brigittie eSantner-Nanan, Rebekah eBrennan, Peter eHsu, Steven eJoung, Ralph eNanan, Scott eBurrows, John J Miles   +7 more
doaj   +1 more source

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

powerTCR: A model-based approach to comparative analysis of the clone size distribution of the T cell receptor repertoire.

PLoS Computational Biology, 2018
Sequencing of the T cell receptor (TCR) repertoire is a powerful tool for deeper study of immune response, but the unique structure of this type of data makes its meaningful quantification challenging.
Hillary Koch, Dmytro Starenki, Sara J Cooper, Richard M Myers, Qunhua Li   +4 more
doaj   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Swift development of protective effector functions in naive CD8(+) T cells against malaria liver stages. [PDF]

, 2001
We generated T cell receptor transgenic mice specific for the liver stages of the rodent malaria parasite Plasmodium yoelii and studied the early events in the development of in vivo effector functions in antigen-specific CD8(+) T cells.
Lafaille, JJ, Gen-ichiro Sano, Alexandre Morrot, Abe, R, Juan J. Lafaille, Fidel Zavala, Sano, G, Ryo Abe, Julius C.R. Hafalla, Hafalla, JC, Morrot, A, Zavala, F   +11 more
core   +1 more source