Results 241 to 250 of about 96,959 (285)

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

Metal-specific T cell receptor repertoire features

Siewert, Katherina, Riedel, Franziska, Aparicio-Soto, Marina, Curato, Caterina   +3 more
core  

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

Multi‐omics biomarkers for intestinal infection and inflammation in inflammatory bowel disease: Current evidence, translational challenges, and diagnostic opportunities

Interdisciplinary Medicine, EarlyView.
Prospective multi‐site cohorts, multi‐omics profiling, and computational analysis may help identify biomarker patterns across clinical settings in IBD and superimposed infections. With further mechanistic and clinical validation, these signals could support the development of practical multi‐analyte tools for more precise diagnosis and management ...
Ziyu Yang, Jiayi Yao, Xinxian Zhao, Yan Xu, Yifan Chen, Tianchi Chen, Ying Jian, Min Li   +7 more
wiley   +1 more source

TCRpred: incorporating T-cell receptor repertoire for clinical outcome prediction. [PDF]

Front Genet
Liu M, Liu Y, Hsu L, He Q.
europepmc   +1 more source

Different Levels, Same Relations? A Meta‐Analysis on the Homology of the Nomological Network of (Daily) Work Engagement

Journal of Organizational Behavior, EarlyView.
ABSTRACT Work engagement has garnered significant attention from researchers and practitioners in recent decades, and several meta‐analyses have examined its stable, between‐person correlates. However, work engagement also has a dynamic component, meaning that it varies daily, across situations, and within individuals.
Jan Luca Pletzer, Nadine Planken, Kimberley Breevaart, Despoina Xanthopoulou, Arnold B. Bakker   +4 more
wiley   +1 more source

Single-cell analysis of the T-cell receptor repertoire in untreated myeloma patients suggests potential myelomareactive CD8⁺ T cells are shared between blood and marrow. [PDF]

Haematologica
Favaloro J, Bryant CE, Abadir E, Gardiner S, Yang S, King T, Nassif N, O'Brien BA, Sedger LM, Boyle R, Joshua DE, Ho PJ.   +11 more
europepmc   +1 more source

The toxin–antitoxin complex Fic‐1–AntF functions as a deAMPylase that regulates the activity of DNA gyrase

mLife, EarlyView.
Abstract Toxin–antitoxin (TA) systems found in diverse bacteria play important roles in their adaptation to changing environments. The toxin of the Fic‐1–AntF TA pair from Pseudomonas bijieensis strain 2P24 inhibits bacterial DNA replication by attacking the subunit B of DNA gyrase (GyrB) via AMPylation, while the antitoxin AntF blocks its enzymatic ...
Furong Chen, Liwei Guo, Canhua Lu, Wenjun Jiang, Zhao‐Qing Luo, Junfeng Liu, Li‐Qun Zhang   +6 more
wiley   +1 more source

Immunoglobulin and T cell receptor repertoire changes induced by a prototype vaccine against Chagas disease in naïve rhesus macaques. [PDF]

J Biomed Sci
Dumonteil E, Tu W, Desale H, Goff K, Marx P, Ortega-Lopez J, Herrera C.   +6 more
europepmc   +1 more source

T cell receptor repertoire characteristics and therapeutic potential of tumor infiltrating lymphocytes (TILs) derived from metastatic lymph node in cervical cancer. [PDF]

Mol Biomed
Zhao X, Liu Z, Qin H, Liu Y, Zhang Y.
europepmc   +1 more source