Results 191 to 200 of about 724,385 (326)

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Lymphocytes and immunoglobulins in peripheral blood and lymphatic fluid of neonates with chylothorax. [PDF]

Front Immunol
De Rose DU, Landolfo F, Pugnaloni F, Gassabi FZ, Martini L, Santisi A, Columbo C, Giliberti P, Gazzotti F, Porzio O, Capponi C, Perno CF, Ronchetti MP, Conforti A, Salvatori G, Capolupo I, Dotta A.   +16 more
europepmc   +1 more source

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

Non-Genetically Modified Adoptive Cell Therapies for Solid Tumors: Current Landscape and Future Challenges. [PDF]

Cancer Immunol Immunother
Luo Q, Jiang W, Xie Y, Dai Z, Zhu J, Du Y, Tao X, Lei Z, Chu X, Wang B, Fu G.   +10 more
europepmc   +1 more source

How Do Cytotoxic Lymphocytes Kill Cancer Cells?

Clinical Cancer Research, 2015
L. Martínez-Lostao, A. Anel, J. Pardo
semanticscholar   +1 more source

METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation

Advanced Science, EarlyView.
METTL5 reshapes the tumor immune microenvironment through ribosome 18S rRNA m6A modification to regulate the translation of chemokine mRNA. Targeting METTL5‐mediated immunosuppression unleashes anti‐tumor immunity and improves the efficacy of anti‐PD‐1 therapy.
Shuang Li, Xiao Zhao, Tongtong Song, Qiaoyi Chen, Yanqing Wu, Yuting Zhang, Jingying Chen, Yifan Wu, Bin Li, Xinyue Zhang, Zihao Dai, Lixia Xu, Yubin Xie, Alfred Sze‐Lok Cheng, Jianping Guo, Ming Kuang, Shuibin Lin, Zhenwei Peng, Sui Peng, Xuezhen Zeng   +19 more
wiley   +1 more source

Hsp70 Peptides Induce TREM-1-Dependent and TREM-1-Independent Activation of Cytotoxic Lymphocytes. [PDF]

Int J Mol Sci
Yurkina DM, Romanova EA, Chernov AS, Gogleva IS, Tvorogova AV, Feoktistov AV, Ziganshin RH, Yashin DV, Sashchenko LP.   +8 more
europepmc   +1 more source

In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine

Nature, 1989
K. Deres, H. Schild, K. Wiesmüller, G. Jung, H. Rammensee   +4 more
semanticscholar   +1 more source

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, EarlyView.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source

Senescent cell accumulation is associated with T-cell imbalance in the skin. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Matveeva KS, Kolmykov SK, Sokolova TS, Salimov DR, Shevyrev DV.   +4 more
europepmc   +1 more source