Results 271 to 280 of about 564,677 (319)
Some of the next articles are maybe not open access.
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
Science, 2020Granzyme A lights a fire Cytotoxic T cells and natural killer cells use several strategies to kill infected or transformed cells. One such pathway entails the delivery of a family of serine proteases called granzymes to target cells through perforin ...
Zhiwei Zhou +14 more
semanticscholar +1 more source
CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review
Journal of Cellular Physiology, 2018CD8+ cytotoxic T lymphocytes (CTLs) are preferred immune cells for targeting cancer. During cancer progression, CTLs encounter dysfunction and exhaustion due to immunerelated tolerance and immunosuppression within the tumor microenvironment (TME), with ...
Bagher Farhood, M. Najafi, K. Mortezaee
semanticscholar +1 more source
Cytotoxic Activity of Lymphocytes
The Journal of Immunology, 1972Abstract Antibody to human lymphotoxin was elicited in rabbits immunized with partially purified supernatants of human spleen cells stimulated by phytohemagglutinin; Anti-LT activity, assayed by neutralizing soluble LT toxicity to indicator mouse L cells, is confined to the immunoglobulin fraction of the serum; it cannot be removed by ...
Sharyn M. Walker, Zoltan J. Lucas
openaire +1 more source
Lymphocyte-Mediated Cytotoxicity
Annual Review of Immunology, 2002Virtually all of the measurable cell-mediated cytotoxicity delivered by cytotoxic T lymphocytes and natural killer cells comes from either the granule exocytosis pathway or the Fas pathway. The granule exocytosis pathway utilizes perforin to traffic the granzymes to appropriate locations in target cells, where they cleave critical substrates that ...
Timothy J. Ley, John H. Russell
openaire +2 more sources
, 2001
Cytotoxic T lymphocytes (CTLs) are T cells that have the ability to recognise and destroy other nucleated target cells that express ‘nonself’ or ‘foreign’ peptide (e.g. derived from viral proteins) in the context of major histocompatibility complex (MHC)
F. Gotch
semanticscholar +1 more source
Cytotoxic T lymphocytes (CTLs) are T cells that have the ability to recognise and destroy other nucleated target cells that express ‘nonself’ or ‘foreign’ peptide (e.g. derived from viral proteins) in the context of major histocompatibility complex (MHC)
F. Gotch
semanticscholar +1 more source
Endocytosis in cytotoxic T-lymphocytes
Cellular Immunology, 1981Abstract Endocytosis in T lymphocytes was analyzed during their differentiation into cytotoxic effector cells in allogeneic mixed lymphocyte cultures. We found that endocytic activity increases from a very low value to reach a peak at Day 5, at which time the cytotoxic titer is highest in these cell cultures.
Heiniger, H J +2 more
openaire +3 more sources
T lymphocytes with promiscuous cytotoxicity
Nature, 1976CYTOTOXIC T lymphocytes generated during a unidirectional mixed lymphocyte culture (MLC) lyse target cells which have the antigenic phenotype of the allogeneic stimulating cells. The cytotoxic effect is restricted to cells that bear the same major histocompatibility antigens (H–2 antigens in mice) as the stimulating cells1.
Chaim Shustik +5 more
openaire +3 more sources
Cytotoxic T lymphocytes and autoimmunity
Current Opinion in Rheumatology, 2005The possibility of the recognition by cytotoxic T lymphocytes of tissue autoantigens has been largely ignored in explaining organ-specific autoimmune diseases. Recent advances in the understanding of human leukocyte antigen class I-binding peptides motifs have led to the detection and the characterization of those autoreactive CD8(+) cytotoxic T ...
Patrick Blanco +3 more
openaire +3 more sources
Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA.
Science, 1998Although cytotoxic T lymphocytes (CTLs) are thought to be involved in the control of human immunodeficiency virus-type 1 (HIV-1) infection, it has not been possible to demonstrate a direct relation between CTL activity and plasma RNA viral load.
G. Ogg +14 more
semanticscholar +1 more source
Studies on the Cytotoxicity of Lymphocytes [PDF]
, 1969 The higher organisms are equipped with two different systems for immunological defence. One system is characterized by the production of humoral antibodies, the other by the appearence of specifically sensitized lymphocytes, which are capable of direct interaction with the antigen.
W. Ax, H. Fischer, I. Zeiss, H. Malchow
openaire +1 more source