Results 281 to 290 of about 564,677 (319)

The stepwise activation of cytotoxic T lymphocytes

Immunology Today, 1987
The recognition of antigen is the first stage of T-lymphocyte maturation in vivo. Monoclonal antibodies directed against the T-cell receptor/CD3 complex and against other surface antigens can also provide this stimulus. Gianni Gromo and his colleagues are attempting to characterize the steps leading from this initial activation to full functional ...
R. L. Geller, Fritz H. Bach, Luca Inverardi, Gianni Gromo, Barbara J. Alter   +4 more
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The Role of Cytoplasmic Granules in Cytotoxicity by Large Granular Lymphocytes and Cytotoxic T Lymphocytes

1985
Three years ago, at the First Workshop on Mechansisms of Cell-Mediated Cytotoxicity, we presented a summary of the evidence developed in our lab that the ADCC and NK cytotoxic functions of large granular lymphocytes (LGL) operated via a secretory process (1).
Pierre A. Henkart, Maryanna Henkart, Peter H. Frederikse, Paul J. Millard, Craig W. Reynolds, Cho Yue, Robert Blumenthal, Jeff Bluestone   +7 more
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Suppressor‐Cytotoxic T‐Lymphocyte Panniculitis

Pediatric Dermatology, 1986
Abstract: A 3½‐year‐old girl had fever and nonsuppurative panniculitis. Biopsies revealed lobular lymphocytic panniculitis. An extensive evaluation of the patient for infectious and other systemic diseases yielded negative results. Although the number of peripheral T lymphocytes was normal, suppressor‐cytotoxic (0KT8) lymphocytes predominated in the ...
Jaime E. Ramirez, Srinivasan Rajaraman, Anand G. Kantak, Armond S. Goldman, Sharon S. Raimer, Alvin R. Solomon   +5 more
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Cytotoxic Lymphocytes

1979
Publisher Summary This chapter discusses cytotoxic lymphocytes. Evaluation of the biological significance of the results of an in vitro assay is critically dependent on the correct assessment of the many limitations of the assay. Lymphocytes are mixed with proper target cells, and the ensuing damage of the latter is measured after incubation under ...
Peter Perlmann, Jean-Charles Cerottini
openaire   +2 more sources

Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine.

Science, 1998
CD8+ cytotoxic T lymphocytes (CTLs) are critical for protection against intracellular pathogens but often have been difficult to induce by subunit vaccines in animals. DNA vaccines elicit protective CD8+ T cell responses.
Ruobing Wang, D. Doolan, T. P. Le, R. Hedstrom, K. Coonan, Y. Charoenvit, T. Jones, P. Hobart, M. Margalith, Jennifer Ng, W. Weiss, M. Sedegah, C. Taisne, J. Norman, S. Hoffman   +14 more
semanticscholar   +1 more source

Inhibition of cytotoxic T lymphocytes with concanavalin A

Cellular Immunology, 1980
Abstract Increasing concentrations of concanavalin A (ConA) were found to increasingly inhibit immunologically specific cytotoxic T lymphocyte (CTL)-mediated cytolysis. Even concentrations of ConA that best enabled nonspecific cytolysis were found to inhibit immunologically specific cytolysis by the same population of effector cells.
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Cytotoxic lymphocytes in melanoma patients

International Journal of Cancer, 1972
AbstractPeripheral blood lymphocytes from 61 melanoma patients were tested by a microcytotoxicity test for cell‐mediated immunity against melanoma cells. Lymphocytes from 13/25 patients were cytotoxic for autologous tumour cells, while lymphocytes from 31/56 patients were cytotoxic in the allogeneic situation.
J P, Faucault, J P, Bernard, J C, Potier, C, Lecacheux   +3 more
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Collaboration of helper and cytotoxic T lymphocytes

European Journal of Immunology, 1993
AbstractCytotoxic T lymphocytes are major effector cells in responses to viral infections and in allograft rejection and are implicated in many other immunological reactions. Efficient induction of cytotoxic activity in these cells in many but not all cases depends upon helper Tand antigen‐presenting cells so that at least three different cell types ...
Peter Walden, Gemot Stuhler
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Activation of Cytotoxic Function in T Lymphocytes

The Journal of Immunology, 1976
Abstract The requirements for activation of cytotoxic function in mouse T lymphocytes were investigated. Initial generation of cytotoxicity in normal lymphocytes was equal in magnitude with either Con A or specific alloantigen, and in either case required DNA synthesis.
Heininger, D, Touton, M, Chakravarty, A K, Clark, W R   +3 more
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Killing mechanisms of cytotoxic lymphocytes

Current Opinion in Hematology, 1997
Killer lymphocytes are primary immune effectors of virus, certain bacteria, and tumor immunity and play a role in autoimmunity and transplant rejection. This article reviews progress in deciphering the mechanisms by which they kill target cells through induction of apoptosis by either the secretory, perforin/granzyme-based pathway or the nonsecretory ...
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