Results 41 to 50 of about 564,677 (319)

State of the immune system in women using the “Provag” probiotic

Медицинская иммунология, 2020
Lactobacilli are  widely used  in clinical  practice as probiotics, biologically  active  additives  and probiotic products for functional nutrition.
V. A. Kozlov, A. G. Borisov, A. A. Savchenko, A. E. Kondakov, I. V. Kudryavtsev   +4 more
doaj   +1 more source

Phytochemical study and evaluation of the cytotoxic properties of methanolic extract from Baccharis obtusifolia [PDF]

International Journal of Medicinal Chemistry, 2018, 2019
Some species of the Baccharis genus have been shown to possess important biomedical properties, including cytotoxic activity. In this study, we examined the cytotoxic effect of methanol extract from Baccharis obtusifolia (Asteraceae) in cancer cell lines of prostate (PC-3), colon (RKO), astrocytoma (D-384), and breast (MCF-7).
arxiv   +1 more source

Lymphocyte Induced Macrophage Cytotoxicity: Characterization of the Macrophage Cytotoxicity-Inducing Lymphocyte

Immunobiology, 1984
The phenotype of lymphocytes, obtained from mice immunized with allogeneic tumor cells, with the capacity to induce macrophage cytotoxicity was determined. Macrophage cytotoxicity was induced, either by incubating the macrophages with Macrophage Arming Factor (MAF) containing supernatants of cultures of sensitized lymphocytes and tumor cells (arming ...
E Pels, W. Den Otter, R.A. de Weger
openaire   +3 more sources

Transcriptional Reprogramming of Mature CD4+ T helper Cells generates distinct MHC class II-restricted Cytotoxic T Lymphocytes

Nature Immunology, 2013
TCRαβ thymocytes differentiate into either CD8αβ+ cytotoxic T lymphocytes or CD4+ helper T cells. This functional dichotomy is controlled by key transcription factors, including the helper T cell master regulator ThPOK, which suppresses the cytolytic ...
D. Mucida, M. M. Husain, Sawako Muroi, F. van Wijk, Ryo Shinnakasu, Y. Naoe, B. Reis, Yujun Huang, F. Lambolez, Michael Docherty, A. Attinger, J. Shui, Gisen Kim, C. Lena, S. Sakaguchi, Chizuko Miyamoto, Peng Wang, K. Atarashi, Yunji Park, T. Nakayama, K. Honda, W. Ellmeier, M. Kronenberg, I. Taniuchi, H. Cheroutre   +24 more
semanticscholar   +1 more source

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

Cellular & Molecular Immunology, 2020
In December 2019, a novel coronavirus was first reported in Wuhan, China. It was named by the World Health Organization as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is responsible for coronavirus disease 2019 (COVID-19).
M. Zheng, Yong Gao, Gang Wang, Guobin Song, Siyu Liu, Dandan Sun, Yuanhong Xu, Z. Tian   +7 more
semanticscholar   +1 more source

Estimation of In-Vitro Free Radical Scavenging and Cytotoxic Activities of Thiocarbohydrazones Derivatives [PDF]

arXiv, 2023
Objective: To investigate free radical scavenging potential of thiocarbohydrazones derivatives for the discovery of antioxidant compounds of synthetic origin. Method: Eighteen thiocarbohydrazones derivatives were screened for antioxidant activities by using in vitro radical inhibition assay.
arxiv  

Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner.

PLoS Pathogens, 2020
Human cytomegalovirus (HCMV) is the most frequent viral cause of congenital defects and can trigger devastating disease in immune-suppressed patients. Cytotoxic lymphocytes (CD8+ T cells and NK cells) control HCMV infection by releasing interferon-γ and ...
Liling Shan, Shuang Li, Jan Meeldijk, Bernadet Blijenberg, Astrid Hendriks, Karlijn J W M van Boxtel, Sara P H van den Berg, Ian J Groves, Martin Potts, Adriana Svrlanska, Thomas Stamminger, Mark R Wills, Niels Bovenschen   +12 more
doaj   +1 more source

Enhanced CXCR4 Expression of Human CD8Low T Lymphocytes Is Driven by S1P4

Frontiers in Immunology, 2021
Although the human immune response to cancer is naturally potent, it can be severely disrupted as a result of an immunosuppressive tumor microenvironment.
Tobias Burkard, Caroline Dreis, Martina Herrero San Juan, Meik Huhn, Andreas Weigert, Josef M. Pfeilschifter, Heinfried H. Radeke   +6 more
doaj   +1 more source

Interferon-γ derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity

Cell Death and Disease, 2017
Interferon gamma (IFNγ) is a key moderator of cell-mediated immunity with diverse, mainly pro-inflammatory actions on immunocytes and target tissue. Recent studies have shown it may enhance anti-tumor and antiviral effects of CD8 T cells.
P. Bhat, G. Leggatt, N. Waterhouse, I. Frazer   +3 more
semanticscholar   +1 more source

Cytotoxic Granule Exocytosis From Human Cytotoxic T Lymphocytes Is Mediated by VAMP7

Frontiers in Immunology, 2019
Cytotoxic T lymphocytes kill infected or malignant cells through the directed release of cytotoxic substances at the site of target cell contact, the immunological synapse.
Praneeth Chitirala, Keerthana Ravichandran, Donatella Galgano, Marwa Sleiman, Elmar Krause, Yenan T. Bryceson, Jens Rettig   +6 more
doaj   +1 more source