Results 31 to 40 of about 8,713,756 (356)

MHCII restriction demonstrates B cells have very limited capacity to activate tumour-specific CD4+ T cells in vivo

OncoImmunology
There has been growing interest in the role of B cells in antitumour immunity and potential use in adoptive cellular therapies. To date, the success of such therapies is limited.
Thomas V. Guy, Alexandra M. Terry, Helen M. McGuire, Elena Shklovskaya, Barbara Fazekas de St Groth   +4 more
doaj   +1 more source

T Cell Hybrids with T Cell Functions

, 1979
Different T cell functions, e.g. help, suppression and cytotoxicity are associated with different T cell subsets, bearing distinctive differentiation markers. Thus effector T cells mediating help are Ly 1+2−3− and may bear Ia determinants, those mediating suppression are Ly 1−2+3+, IJ+, and cytotoxic cells are Ly 1−2+3+ and do not bear Ia determinants (
Simpson, E, Kontiainen, S, Herzenberg, L, Bohrer, E, Torano, A, Vogt, P, Beverley, P, Fitzpatrick, W, Feldmann, M   +8 more
openaire   +3 more sources

Deterministic mechanical model of T-killer cell polarization reproduces the wandering of aim between simultaneously engaged targets [PDF]

, 2009
T-killer cells of the immune system eliminate virus-infected and tumorous cells through direct cell-cell interactions. Reorientation of the killing apparatus inside the T cell to the T-cell interface with the target cell ensures specificity of the immune
A Ashkin, A Kupfer, B Alberts, B Mickey, C Kozlowski, D Depoil, EL Botvinick, EN Cytrynbaum, F Nédélec, IA Vorobjev, IA Vorobjev, IV Maly, Ivan V. Maly, J Combs, Jason A. Papin, JM Serrador, JR Kuhn, Mun Ju Kim, S Valitutti, SW Grill, T Mitchison, T Takasone, TL Hill, W Press   +23 more
core   +7 more sources

Cognate Interaction With CD4+ T Cells Instructs Tumor-Associated Macrophages to Acquire M1-Like Phenotype

Frontiers in Immunology, 2019
The immunosuppressive tumor microenvironment (TME) established by tumor cells, stromal cells and inhibitory immune cells counteracts the function of tumor reactive T cells.
David Eisel, David Eisel, David Eisel, Krishna Das, Krishna Das, Krishna Das, Elke Dickes, Rainer König, Wolfram Osen, Stefan B. Eichmüller   +9 more
doaj   +1 more source

Differential susceptibility and role for senescence in CART cells based on costimulatory domains

Molecular Cancer
Despite the success of chimeric antigen receptor T (CART) cell therapy in hematological malignancies, durable remissions remain low. Here, we report CART senescence as a potential resistance mechanism in 41BB-costimulated CART cell therapy.
Ismail Can, Elizabeth L. Siegler, Olivia L. Sirpilla, Claudia Manriquez-Roman, Kun Yun, Carli M. Stewart, Jennifer M. Feigin, Makena L. Rodriguez, Omar L. Gutierrez-Ruiz, Ekene J. Ogbodo, Truc N. Huynh, Brooke L. Kimball, Long K. Mai, Mehrdad Hefazi, Lionel Kankeu Fonkoua, Hong Xia, Imene Hamaidi, Berke Alkan, Fatih Sezer, H. Atakan Ekiz, R. Leo Sakemura, Saad S. Kenderian   +21 more
doaj   +1 more source

Phylogenetic analysis of the SINA/SIAH ubiquitin E3 ligase family in Metazoa

BMC Evolutionary Biology, 2017
Background The RAS signaling pathway is a pivotal developmental pathway that controls many fundamental biological processes including cell proliferation, differentiation, movement and apoptosis.
Ian J. Pepper, Robert E. Van Sciver, Amy H. Tang   +2 more
doaj   +1 more source

An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation. [PDF]

, 2019
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for multiple disorders, but deficiency and dysregulation of T cells limit its utility.
Deruaz, Maud, Kerr, Matthew D, Mao, Angelo S, Mooney, David J, Raimondo, Theresa M, Scadden, David T, Shah, Nisarg J, Sharda, Azeem, Shih, Ting-Yu, Tager, Andrew M, Vrbanac, Vladimir D, Weaver, James C   +11 more
core   +1 more source

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

IL-4 drives exhaustion of CD8+ CART cells

Nature Communications
Durable response to chimeric antigen receptor T (CART) cell therapy remains limited in part due to CART cell exhaustion. Here, we investigate the regulation of CART cell exhaustion with three independent approaches including: a genome-wide CRISPR ...
Carli M. Stewart, Elizabeth L. Siegler, R. Leo Sakemura, Michelle J. Cox, Truc Huynh, Brooke Kimball, Long Mai, Ismail Can, Claudia Manriquez Roman, Kun Yun, Olivia Sirpilla, James H. Girsch, Ekene Ogbodo, Wazim Mohammed Ismail, Alexandre Gaspar-Maia, Justin Budka, Jenny Kim, Nathalie Scholler, Mike Mattie, Simone Filosto, Saad S. Kenderian   +20 more
doaj   +1 more source

MALT1 proteolytic activity suppresses autoimmunity in a T cell intrinsic manner [PDF]

, 2019
MALT1 is a central signaling component in innate and adaptive immunity by regulating NF-kappa B and other key signaling pathways in different cell types. Activities of MALT1 are mediated by its scaffold and protease functions.
Baens, Mathijs, Beyaert, Rudi, Demeyer, Annelies, Driege, Yasmine, Hochepied, Tino, Kreike, Marja, Skordos, Ioannis, Staal, Jens   +7 more
core   +2 more sources