Results 71 to 80 of about 1,940,376 (313)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol (4,5) bisphosphate controls T cell activation by regulating T cell rigidity and organization. [PDF]

PLoS ONE, 2011
Here we investigate the role of Phosphatidylinositol (4,5) bisphosphate (PIP(2)) in the physiological activation of primary murine T cells by antigen presenting cells (APC) by addressing two principal challenges in PIP(2) biology.
Yi Sun, Radhika D Dandekar, Yuntao S Mao, Helen L Yin, Christoph Wülfing   +4 more
doaj   +1 more source

Adaptor SKAP-55 binds p21ras activating exchange factor RasGRP1 and negatively regulates the p21ras-ERK pathway in T-Cells

, 2008
While the adaptor SKAP-55 mediates LFA-1 adhesion on T-cells, it is not known whether the adaptor regulates other aspects of signaling. SKAP-55 could potentially act as a node to coordinate the modulation of adhesion with downstream signaling.
Lovatt Matt, Christopher E Rudd, Wu, Zhonglin, Schneider, Helga, Rudd Christopher E., Maqueira-Iglesias, Braudel, Matt Lovatt, Schneider Helga, Monika Raab, Valk, Elke, Smith, Xin, Zhonglin Wu, Klaus Strebhardt, Elke Valk, Strebhardt, Klaus, Rudd, Christopher E., Valk Elke, Strebhardt Klaus, Wang Hongyan, Wu Zhonglin, Braudel Maqueira-Iglesias, Maqueira-Iglesias Braudel, Helga Schneider, Xin Smith, Lovatt, Matt, Raab Monika, Raab, Monika, Wang, Hongyan, Smith Xin, Hongyan Wang   +29 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Functional interactions of the Tax and p13 proteins of Human T-cell Leukemia Virus Type I [PDF]

, 2013
Human T-cell leukemia virus type 1 (HTLV-1) establishes a lifelong persistent infection in humans. Approximately 3% of the infected individuals will develop adult T-cell leukemia/lymphoma (ATLL), an aggressive malignancy of mature CD4+ T-cells. The viral
Manicone, Mariangela
core  

T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase [PDF]

, 2001
After stimulation of the T cell receptor (TCR), the tyrosine residues 292 and 315 in interdomain B of the protein tyrosine kinase ZAP-70 become phosphorylated and plausibly function as docking sites for Cbl and Vav1, respectively. The two latter proteins
Magnan, A, Anne Gillet, Arrieumerlou, C, Antoine Magnan, Boyer, C, Malissen, Bernard, Vincenzo Di Bartolo, Mireille Richelme, Marie Malissen, Lin, YL, Gillet, A., Roure, A, Mura, A. M., Boyer, C., Malissen, B, Arrieumerlou, C., Malissen, M., Malissen, M, Roure, A., Richelme, M, Acuto, O, Lin, Y. L., Bernard Malissen, Claude Boyer, Malissen, B., Di Bartolo, V, Cécile Arrieumerlou, Yea-Lih Lin, Agnès Roure, Oreste Acuto, Mura, AM, Acuto, O., Richelme, M., Acuto, Oreste, Di Bartolo, V., Anne-Marie Mura, Gillet, A, Boyer, Claudine, Magnan, A.   +38 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Evaluation of LIGHT-derived peptides to disrupt the HVEM/LIGHT immune checkpoint

Scientific Reports
Immune checkpoints are critical regulators of immune homeostasis and have become prominent targets in the treatment of various malignancies and autoimmune disorders. While monoclonal antibodies currently dominate checkpoint-targeted therapies, there is a
Piotr Ciura, Simon Gumpelmair, Sylwia Rodziewicz-Motowidło, Peter Steinberger, Marta Spodzieja, Adam K. Sieradzan   +5 more
doaj   +1 more source

Rac activation by the T-cell receptor inhibits T cell migration.

PLoS ONE, 2010
BackgroundT cell migration is essential for immune responses and inflammation. Activation of the T-cell receptor (TCR) triggers a migration stop signal to facilitate interaction with antigen-presenting cells and cell retention at inflammatory sites, but ...
Eva Cernuda-Morollón, Jaime Millán, Mark Shipman, Federica M Marelli-Berg, Anne J Ridley   +4 more
doaj   +1 more source

Core Fucosylation of the T Cell Receptor Is Required for T Cell Activation

Frontiers in Immunology, 2018
CD4+ T cell activation promotes the pathogenic process of systemic lupus erythematosus (SLE). T cell receptor (TCR) complex are highly core fucosylated glycoproteins, which play important roles in T cell activation.
Wei Liang, Shanshan Mao, Shijie Sun, Ming Li, Zhi Li, Rui Yu, Tonghui Ma, Jianguo Gu, Jianing Zhang, Naoyuki Taniguchi, Wenzhe Li   +10 more
doaj   +1 more source