Results 81 to 90 of about 1,940,376 (313)

Co-receptor CD8-mediated modulation of T-cell receptor functional sensitivity and epitope recognition degeneracy [PDF]

, 2013
The interaction between T-cell receptors (TCRs) and peptide epitopes is highly degenerate: a TCR is capable of interacting productively with a wide range of different peptide ligands, involving not only cross-reactivity proper (similar epitopes elicit ...
Linda Wooldridge, van den Berg, Hugo Antonius, Dockree, Tamsin, Van Den Berg, Hugo A, Berg, Hugo van den, Linda eWooldridge, Williams, Tamsin, Barbara Szomolay, Tamsin eWlliams, Tamsin Williams, Szomolay, Barbara, Hugo Antonius Van Den Berg, Barbara eSzomolay, Wooldridge, Linda   +13 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Modulation of NF-kappaB activation in Theileria annulata-infected cloned cell lines is associated with detection of parasite-dependent IKK signalosomes and disruption of the actin cytoskeleton [PDF]

, 2010
Apicomplexan parasites within the genus <i>Theileria</i> have the ability to induce continuous proliferation and prevent apoptosis of the infected bovine leukocyte.
Weir, W., Hermann, P., McKellar, S., Dobbelaere, D., Dobbelaere, Dirk,, Schmuckli-Maurer, J., Pillai, S., Shiels, B., Kinnaird, J.   +8 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Metabolic regulation of regulatory T cell development and function

, 2014
It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require ATP-generating processes, whereas proliferating Teff require high metabolic flux through growth ...
Marelli-Berg, F, Madhav eKishore, Kishore, M, Federica eMarelli-Berg, Federica Marelli-Berg, Coe, DJ, David John Coe, Madhav Kishore   +7 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

T Cell Activation Depends on Extracellular Alanine

Cell Reports, 2019
Summary: T cell stimulation is metabolically demanding. To exit quiescence, T cells rely on environmental nutrients, including glucose and the amino acids glutamine, leucine, serine, and arginine.
Noga Ron-Harel, Jonathan M. Ghergurovich, Giulia Notarangelo, Martin W. LaFleur, Yoshiki Tsubosaka, Arlene H. Sharpe, Joshua D. Rabinowitz, Marcia C. Haigis   +7 more
doaj   +1 more source

T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers. [PDF]

PLoS ONE, 2017
Kv1.3 is a voltage-gated potassium channel expressed on T cells that plays an important role in T cell activation. Previous studies have shown that blocking Kv1.3 channels in human T cells during activation results in reduced calcium entry, cytokine ...
Wai-Ping Fung-Leung, Wilson Edwards, Yi Liu, Karen Ngo, Julianty Angsana, Glenda Castro, Nancy Wu, Xuejun Liu, Ronald V Swanson, Alan D Wickenden   +9 more
doaj   +1 more source

Hybrid Spreading Mechanisms and T Cell Activation Shape the Dynamics of HIV-1 Infection

, 2015
HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts.
Pellegrino, P, Groppelli, E, Elisabetta Groppelli (258517), Jolly, C, Ian Williams (208301), Changwang Zhang (716808), Persephone Borrow, Borrow, P, Chain, BM, Benjamin M Chain, Zhou, S, Zhou, Shi, Groppelli, Elisabetta, Persephone Borrow (194557), Ian Williams, Zhang, Changwang, Pellegrino, Pierre, Changwang Zhang, Jolly, Clare, Elisabetta Groppelli, Shi Zhou, Clare Jolly (207781), Pierre Pellegrino (208300), Benjamin M. Chain (154754), Pierre Pellegrino, Williams, Ian, Borrow, Persephone, Shi Zhou (452014), Zhang, C, Chain, Benjamin M., Williams, I, Clare Jolly   +31 more
core   +1 more source

Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. [PDF]

, 2012
Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal.
Mitchell, T.J., Timothy J. Mitchell (150478), Moira K. B. Whyte (150482), David H. Dockrell (114218), Read Robert C., Daigneault, Marc, Daigneault Marc, De Silva, T.I., Helen M. Marriott (150472), De Silva Thushan I., Marriott, Helen M, Preston, Julie A, Dockrell, David H, Marriott, H.M., Julie A Preston, Thushan I. De Silva, De Silva, Thushan I., Dockrell, David H., Whyte, M.K.B., Martin A. Bewley, Preston, Julie A., Mitchell Timothy J., Andrea M. Mitchell, Timothy J Mitchell, Whyte, Moira K B, Mitchell Andrea M., Thushan I. De Silva (150466), Moira K. B. Whyte, Preston Julie A., Helen M Marriott, Preston, J.A., Martin A. Bewley (150467), Robert C Read, Bewley, M.A., Marc Daigneault (150463), Marc Daigneault, Dockrell, D.H., Mitchell, Andrea M; id_orcid, Whyte Moira K. B., Whyte, Moira K. B., Marriott Helen M., Mitchell, Andrea M., Read, Robert C., Robert C. Read (145234), De Silva, Thushan I, Mitchell, Timothy J., Read, R.C., David H. Dockrell, Julie A. Preston (150469), Andrea M. Mitchell (150475), Mitchell, Timothy J, David H Dockrell, Moira K B Whyte, Marriott, Helen M., Mitchell, A.M., Timothy J. Mitchell, Andrea M Mitchell, Bewley, Martin A, Daigneault, M., Read, Robert C, Robert C. Read, Dockrell David H., Bewley, Martin A., Martin A Bewley, Helen M. Marriott, Julie A. Preston, Dockrell, David, Bewley Martin A., Thushan I De Silva   +68 more
core   +1 more source